Acceleration of the cell cycle drives the outgrowth of the regenerating spinal cord in axolotls

Fabian Rost1†, Aida Rodrigo Albors*2,3,4†, Vladimir Mazurov3,4, Lutz Brusch1, Andreas Deutsch1, Elly M. Tanaka3,4‡* and Osvaldo Chara1,5‡*

1 Center for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany
2Division of Cell & Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom
3 Deutsche Forschungsgemeinschaft – Center for Regenerative Therapies Dresden, Dresden, Germany
4 Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
5 Systems Biology Group (SysBio), Institute of Physics of Liquids and Biological Systems, National Scientific and Technical Research Council (CONICET) and University of La Plata, La Plata, Argentina

Co-first authorship Co-last authorship \* Corresponding authors

Corresponding authors:

Osvaldo Chara
Center for Information Services and High Performance Computing, Technische Universität Dresden, Nöthnitzer Straße 46, 01187 Dresden, Germany
Tel. +49 351 463-38780
E-mail: osvaldo.chara@tu-dresden.de

Systems Biology Group (SysBio), Institute of Physics of Liquids and Biological Systems (IFLySIB), National Scientific and Technical Research Council (CONICET) and University of La Plata
Calle 59 N 789, 1900 La Plata, Argentina
Tel. +54 221 4233283 Ext: 26
E-mail: ochara@iflysib.unlp.edu.ar

Elly Tanaka
CRTD
Fetscherstraβe 105, 01307 Dresden, Germany
Tel. +49 351 458-82000
Fax +49 351 458-82009
E-mail: elly.tanaka@crt-dresden.de

Introduction

These notebook were used to perform data analysis presented in Rost et al., in preparation. It contains all the data and the code for the data analysis. The code is only partly documented. If you have questions concerning the code, please contact the authors.

Please also make sure you visited https://github.com/fabianrost84/Rost-Rodrigo-Albors-et-al-2016 to make sure you have the latest version of the notebooks and for getting instructions how to view them and/or get them running.

Dependencies

The notebooks depend on the python modules below. Python 2.7 was used. If the import works, the notebooks should hopefully work. The repository also contains an environment.yml file which can be used with conda to set up a working python environment.


In [1]:
%load_ext ipycache
import cloudpickle
import collections
import datetime
import functools
import gc
import iminuit
import pandas as pd
import matplotlib as mpl
import matplotlib.pyplot as plt
import matplotlib.gridspec as gridspec
from matplotlib import ticker
%matplotlib inline
%config InlineBackend.figure_format = 'svg'
import os
import multiprocessing
import numba
import probfit
import pymc
import tables
import random
import scipy as sp
from scipy import stats
import scipy.optimize
import shutil
from uncertainties import ufloat
import warnings


/home/fabian/anaconda2/lib/python2.7/site-packages/IPython/config.py:13: ShimWarning: The `IPython.config` package has been deprecated. You should import from traitlets.config instead.
  "You should import from traitlets.config instead.", ShimWarning)
/home/fabian/anaconda2/lib/python2.7/site-packages/IPython/utils/traitlets.py:5: UserWarning: IPython.utils.traitlets has moved to a top-level traitlets package.
  warn("IPython.utils.traitlets has moved to a top-level traitlets package.")

List of notebooks

References

Rodrigo Albors, A., Tazaki, A., Rost, F., Nowoshilow, S., Chara, O., & Tanaka, E. M. (2015). Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration. eLife, e10230. http://doi.org/10.7554/eLife.10230


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