Single Replica TIS

This notebook shows how to run single replica TIS move scheme. This assumes you can load engine, network, and initial sample from a previous calculation.


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%matplotlib inline
import openpathsampling as paths
import numpy as np
import matplotlib.pyplot as plt
import pandas as pd

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from openpathsampling.visualize import PathTreeBuilder, PathTreeBuilder
from IPython.display import SVG, HTML

def ipynb_visualize(movevis):
    """Default settings to show a movevis in an ipynb."""
    view = movevis.renderer
    view.zoom = 1.5
    view.scale_y = 18
    view.scale_th = 20
    view.font_size = 0.4
    return view

Open the storage and load things from it.


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old_store = paths.AnalysisStorage("mstis.nc")
#old_store = paths.Storage("mstis.nc")  # if not actually doing analysis, but loading network, etc

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network = old_store.networks[0]
engine = old_store.engines[0]
template = old_store.snapshots[0]

One of the points of SRTIS is that we use a bias (which comes from an estimate of the crossing probability) in order to improve our sampling.


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# this is how we would get it out of a simulation (although the actual simulation here has bad stats)
# first, we need the crossing probabilities, which we get when we calculate the rate
network.hist_args['max_lambda'] = { 'bin_width' : 0.02, 'bin_range' : (0.0, 0.5) }
network.hist_args['pathlength'] = { 'bin_width' : 5, 'bin_range' : (0, 150) }
rates = network.rate_matrix(old_store.steps)

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# just use the analyzed network to make the bias
bias = paths.SRTISBiasFromNetwork(network)
bias.df

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# For better stats, use the results that I got from a 20k MC step run
# We can create fake TCPs and force them on the network.

tcp_A = paths.numerics.LookupFunction.from_dict(
    {0.2: 1.0,
     0.3: 0.13293104100673198,
     0.4: 0.044370838092911397,
     0.5: 0.021975696374764188}
)
tcp_B = paths.numerics.LookupFunction.from_dict(
    {0.2: 1.0,
     0.3: 0.13293104100673198,
     0.4: 0.044370838092911397,
     0.5: 0.021975696374764188}
)
tcp_C = paths.numerics.LookupFunction.from_dict(
    {0.2: 1.0,
     0.3: 0.19485705066078274,
     0.4: 0.053373003923696649,
     0.5: 0.029175949467020165}
)

# load states for identification purposes
stateA = old_store.volumes['A']
stateB = old_store.volumes['B']
stateC = old_store.volumes['C']

# use the sampling transitions; in MSTIS, these are also stored in from_state
network.from_state[stateA].tcp = tcp_A
network.from_state[stateB].tcp = tcp_B
network.from_state[stateC].tcp = tcp_C

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bias = paths.SRTISBiasFromNetwork(network)
bias.df

Here we actually set up the SRTIS move scheme for the given network. It only requires one line:


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scheme = paths.SRTISScheme(network, bias=bias, engine=engine)

Now we'll visualize the SRTIS move scheme.


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movevis = paths.visualize.MoveTreeBuilder()
#movevis.mover(scheme.move_decision_tree(), network.all_ensembles)
#SVG(ipynb_visualize(movevis).to_svg())

Next we need to set up an appropriate single-replica initial sampleset. We'll take the last version of from one of the outer TIS ensembles.


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final_samp0 = old_store.steps[len(old_store.steps)-1].active[network.sampling_ensembles[-1]]

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sset = paths.SampleSet([final_samp0])

Finally, we set up the new storage file and the new simulation.


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storage = paths.Storage("srtis.nc", "w")
storage.save(template)

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srtis = paths.PathSampling(
    storage=storage,
    sample_set=sset,
    move_scheme=scheme
)

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n_steps_to_run = int(scheme.n_steps_for_trials(
        mover=scheme.movers['minus'][0], 
        n_attempts=1
    ))
print(n_steps_to_run)

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# logging creates ops_output.log file with details of what the calculation is doing
#import logging.config
#logging.config.fileConfig("logging.conf", disable_existing_loggers=False)

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%%time
multiplier = 2
srtis.run_until(multiplier*n_steps_to_run)

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#storage.close()

From here, we'll be doing the analysis of the SRTIS run.


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%%time
#storage = paths.AnalysisStorage("srtis.nc")
#scheme = storage.schemes[0]

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scheme.move_summary(storage.steps)

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scheme.move_summary(storage.steps, 'shooting')

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scheme.move_summary(storage.steps, 'minus')

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scheme.move_summary(storage.steps, 'repex')

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scheme.move_summary(storage.steps, 'pathreversal')

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replica = storage.samplesets[0].samples[0].replica
ensemble_trace = paths.trace_ensembles_for_replica(replica, storage.steps)
print len(ensemble_trace)

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srtis_ensembles = scheme.network.sampling_ensembles+scheme.network.special_ensembles['ms_outer'].keys()
srtis_ensemble_numbers = {e : srtis_ensembles.index(e) for e in srtis_ensembles}
# this next is just for pretty printing
srtis_numbers_ensemble = {srtis_ensemble_numbers[e] : e for e in srtis_ensemble_numbers}
for k in sorted(srtis_numbers_ensemble.keys()):
    print k, ":", srtis_numbers_ensemble[k].name

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plt.plot([srtis_ensemble_numbers[e] for e in ensemble_trace])

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count = 0
for i in range(len(ensemble_trace)-1):
    [this_val, next_val] = [srtis_ensemble_numbers[ensemble_trace[k]] for k in [i,i+1]]
    if this_val == 1 and next_val == 0:
        count += 1
count

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hist_numbers = [srtis_ensemble_numbers[e] for e in ensemble_trace]
bins = [i-0.5 for i in range(len(srtis_ensembles)+1)]

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plt.hist(hist_numbers, bins=bins);

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import pandas as pd
hist = paths.analysis.Histogram(bin_width=1.0, bin_range=[-0.5,9.5])
colnames = {i : srtis_numbers_ensemble[i].name for i in range(len(srtis_ensembles))}
df = pd.DataFrame(columns=[colnames[i] for i in colnames])

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for i in range(len(hist_numbers)):
    hist.add_data_to_histogram([hist_numbers[i]])
    if i % 100 == 0:
        normalized = hist.normalized()
        local_df = pd.DataFrame([normalized.values()], index=[i], columns=[colnames[k] for k in normalized.keys()])
        df = df.append(local_df)

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plt.pcolormesh(df.fillna(0.0), cmap="bwr", vmin=0.0, vmax=0.2);
plt.gca().invert_yaxis()
plt.colorbar()

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