In [20]:
line = """IF #CAMPO-PACK (#IDX)            =    MASK ('            'N','NN)"""

In [21]:
line = line.replace("=", "EQ")
if_old = "".join("".join(line.split("EQ")[0]).strip().split()[1:])
if_old


Out[21]:
'#CAMPO-PACK(#IDX)'

In [18]:
line = """                              OR=   MASK ('           'NN','NN)"""

In [19]:
line.strip().startswith("OR=")


Out[19]:
True

In [16]:
line.replace("OR=", "OR {} EQ".format(if_old)).strip()


Out[16]:
"OR #CAMPO-PACK EQ   MASK ('           'NN','NN)"