notebook.community

Edit and run



In [1]:

    
%matplotlib inline



In [2]:

    
#
# Remember to 
#
#



In [3]:

    
from ipython_memwatcher import MemWatcher
mw = MemWatcher()
mw.start_watching_memory()









    



In [3] used 0.008 MiB RAM in 0.001s, peaked 0.000 MiB above current, total RAM usage 60.938 MiB



In [4]:

    
import glob
import pandas as pd
import numpy as np
import seaborn as sns
import matplotlib.pyplot as plt
import matplotlib
pd.set_option('display.max_columns', 50) # print all rows


import os
os.chdir('/Users/evanbiederstedt/Downloads/RRBS_data_files')

import statsmodels.api as sm









    



In [4] used 42.066 MiB RAM in 0.943s, peaked 0.000 MiB above current, total RAM usage 103.004 MiB



In [5]:

    
"""

CD19cell_regions.csv
cw154_regions.csv
Normal_B_regions.csv
trito_regions.csv
pcell_regions.csv
mcell_regions.csv

"""









    Out[5]:





'\n\nCD19cell_regions.csv\ncw154_regions.csv\nNormal_B_regions.csv\ntrito_regions.csv\npcell_regions.csv\nmcell_regions.csv\n\n'






    



In [5] used 0.043 MiB RAM in 0.006s, peaked 0.000 MiB above current, total RAM usage 103.047 MiB



In [6]:

    
trito = pd.read_csv("trito_regions.csv")
normal = pd.read_csv("Normal_B_regions.csv")
pcell = pd.read_csv("pcell_regions.csv")
mcell = pd.read_csv("mcell_regions.csv")
cw154 = pd.read_csv("cw154_regions.csv")
cd19cell = pd.read_csv("CD19cell_regions.csv")









    



In [6] used 0.840 MiB RAM in 0.048s, peaked 0.016 MiB above current, total RAM usage 103.887 MiB



In [7]:

    
print(trito.shape)
print(normal.shape)   # remove 2cell files
print(pcell.shape)
print(mcell.shape)
print(cw154.shape)
print(cd19cell.shape)









    



(44, 39)
(136, 39)
(90, 39)
(88, 39)
(66, 39)
(89, 39)
In [7] used 0.043 MiB RAM in 0.003s, peaked 0.000 MiB above current, total RAM usage 103.930 MiB



In [8]:

    
trito["filename"] = trito["filename"].str[:33]









    



In [8] used 0.086 MiB RAM in 0.003s, peaked 0.000 MiB above current, total RAM usage 104.016 MiB



In [9]:

    
trito.head()









    Out[9]:






  
    
      
      filename
      methylation_tssDistance
      methylation_genesDistance
      methylation_exonsDistance
      methylation_intronsDistance
      methylation_promoterDistance
      methylation_cgiDistance
      methylation_ctcfDistance
      methylation_ctcfUpDistance
      methylation_ctcfDownDistance
      methylation_geneDistalRegulatoryModulesDistance
      methylation_vistaEnhancersDistance
      methylation_3PrimeUTRDistance
      methylation_5PrimeUTRDistance
      methylation_firstExonDistance
      methylation_geneDistalRegulatoryModulesK562Distance
      methylation_hypoInHues64Distance
      methylation_intergenic
      methylation_shore
      methylation_shelf
      PDR_tssDistance
      PDR_genesDistance
      PDR_exonsDistance
      PDR_intronsDistance
      PDR_promoterDistance
      PDR_cgiDistance
      PDR_ctcfDistance
      PDR_ctcfUpDistance
      PDR_ctcfDownDistance
      PDR_geneDistalRegulatoryModulesDistance
      PDR_vistaEnhancersDistance
      PDR_3PrimeUTRDistance
      PDR_5PrimeUTRDistance
      PDR_firstExonDistance
      PDR_geneDistalRegulatoryModulesK562Distance
      PDR_hypoInHues64Distance
      PDR_intergenic
      PDR_shore
      PDR_shelf
    
  
  
    
      0
      RRBS_trito_pool_1_TAAGGCGA.ACAACC
      0.0
      0.570721
      0.404589
      0.594704
      0.146371
      0.169386
      0.199815
      0.0
      0.199815
      0.342986
      0.444522
      0.680480
      0.305206
      0.145730
      0.254209
      0.877142
      0.820339
      0.607671
      0.803716
      0.0
      0.343014
      0.371890
      0.339596
      0.347748
      0.388709
      0.385297
      0.0
      0.385297
      0.401254
      0.509555
      0.386285
      0.324236
      0.367271
      0.354046
      0.240359
      0.386809
      0.377907
      0.359143
    
    
      1
      RRBS_trito_pool_1_TAAGGCGA.ACGTGG
      0.0
      0.545781
      0.383371
      0.568638
      0.141545
      0.161519
      0.191404
      0.0
      0.191404
      0.326140
      0.589834
      0.670559
      0.290196
      0.140779
      0.240221
      0.809942
      0.816166
      0.573089
      0.795932
      0.0
      0.348110
      0.381251
      0.341950
      0.349891
      0.398898
      0.415058
      0.0
      0.415058
      0.408417
      0.548192
      0.382172
      0.332749
      0.373615
      0.359217
      0.364148
      0.391925
      0.386808
      0.354120
    
    
      2
      RRBS_trito_pool_1_TAAGGCGA.ACTCAC
      0.0
      0.564547
      0.401760
      0.588136
      0.148529
      0.174413
      0.209041
      0.0
      0.209041
      0.346473
      0.553062
      0.696068
      0.296809
      0.148360
      0.255392
      0.795883
      0.832812
      0.609544
      0.812564
      0.0
      0.338412
      0.371890
      0.332321
      0.351391
      0.393829
      0.392313
      0.0
      0.392313
      0.412311
      0.471703
      0.378630
      0.327488
      0.370494
      0.338321
      0.334783
      0.378580
      0.378799
      0.353949
    
    
      3
      RRBS_trito_pool_1_TAAGGCGA.AGGATG
      0.0
      0.567309
      0.399934
      0.592890
      0.143897
      0.168936
      0.200661
      0.0
      0.200661
      0.342257
      0.665920
      0.661426
      0.308680
      0.141673
      0.242236
      0.787966
      0.824659
      0.602995
      0.799836
      0.0
      0.342724
      0.374419
      0.337654
      0.346109
      0.389718
      0.399153
      0.0
      0.399153
      0.405627
      0.359189
      0.391002
      0.324431
      0.360431
      0.343730
      0.304035
      0.380413
      0.373345
      0.347372
    
    
      4
      RRBS_trito_pool_1_TAAGGCGA.ATAGCG
      0.0
      0.529224
      0.367743
      0.555131
      0.136090
      0.156827
      0.175426
      0.0
      0.175426
      0.307402
      0.479145
      0.644411
      0.273473
      0.134137
      0.220729
      0.815944
      0.808981
      0.575050
      0.788587
      0.0
      0.349254
      0.376307
      0.342617
      0.343348
      0.388623
      0.403861
      0.0
      0.403861
      0.390288
      0.471324
      0.392438
      0.332882
      0.358450
      0.319824
      0.401641
      0.398275
      0.373236
      0.363320
    
  








    



In [9] used 0.219 MiB RAM in 0.108s, peaked 0.000 MiB above current, total RAM usage 104.234 MiB



In [10]:

    
normal["filename"] = normal["filename"].str[:40]









    



In [10] used -0.016 MiB RAM in 0.003s, peaked 0.016 MiB above current, total RAM usage 104.219 MiB



In [11]:

    
normal.tail()









    Out[11]:






  
    
      
      filename
      methylation_tssDistance
      methylation_genesDistance
      methylation_exonsDistance
      methylation_intronsDistance
      methylation_promoterDistance
      methylation_cgiDistance
      methylation_ctcfDistance
      methylation_ctcfUpDistance
      methylation_ctcfDownDistance
      methylation_geneDistalRegulatoryModulesDistance
      methylation_vistaEnhancersDistance
      methylation_3PrimeUTRDistance
      methylation_5PrimeUTRDistance
      methylation_firstExonDistance
      methylation_geneDistalRegulatoryModulesK562Distance
      methylation_hypoInHues64Distance
      methylation_intergenic
      methylation_shore
      methylation_shelf
      PDR_tssDistance
      PDR_genesDistance
      PDR_exonsDistance
      PDR_intronsDistance
      PDR_promoterDistance
      PDR_cgiDistance
      PDR_ctcfDistance
      PDR_ctcfUpDistance
      PDR_ctcfDownDistance
      PDR_geneDistalRegulatoryModulesDistance
      PDR_vistaEnhancersDistance
      PDR_3PrimeUTRDistance
      PDR_5PrimeUTRDistance
      PDR_firstExonDistance
      PDR_geneDistalRegulatoryModulesK562Distance
      PDR_hypoInHues64Distance
      PDR_intergenic
      PDR_shore
      PDR_shelf
    
  
  
    
      131
      RRBS_normal_B_cell_H1_22_TAGGCATG.GTGAGG
      0.0
      0.476010
      0.319477
      0.501080
      0.112156
      0.125920
      0.140172
      0.0
      0.140172
      0.266191
      0.520634
      0.568097
      0.250866
      0.108529
      0.199670
      0.743346
      0.709026
      0.512304
      0.723009
      0.0
      0.413186
      0.417787
      0.411922
      0.371247
      0.397676
      0.361732
      0.0
      0.361732
      0.449309
      0.538398
      0.431550
      0.378186
      0.390782
      0.390614
      0.433456
      0.526395
      0.438160
      0.468283
    
    
      132
      RRBS_normal_B_cell_H1_22_TAGGCATG.GTTGAG
      0.0
      0.561826
      0.421027
      0.581238
      0.194894
      0.241158
      0.227289
      0.0
      0.227289
      0.355498
      0.652030
      0.675360
      0.320042
      0.195983
      0.239473
      0.848333
      0.775009
      0.603093
      0.765059
      0.0
      0.378380
      0.397910
      0.375394
      0.389046
      0.412999
      0.390730
      0.0
      0.390730
      0.430454
      0.628598
      0.406830
      0.371516
      0.395340
      0.389081
      0.268990
      0.455415
      0.396795
      0.385031
    
    
      133
      RRBS_normal_B_cell_H1_22_TAGGCATG.TAGCGG
      0.0
      0.403834
      0.204255
      0.435666
      0.094118
      0.093855
      0.072948
      0.0
      0.072948
      0.253112
      0.333333
      0.591837
      0.223590
      0.096000
      0.223404
      0.818182
      0.820471
      0.605528
      0.801020
      0.0
      0.320128
      0.375319
      0.314522
      0.375959
      0.383838
      0.258359
      0.0
      0.258359
      0.396266
      1.000000
      0.346939
      0.411282
      0.409333
      0.386525
      0.818182
      0.311942
      0.381910
      0.306122
    
    
      134
      RRBS_normal_B_cell_H1_22_TAGGCATG.TATCTC
      0.0
      0.601704
      0.464233
      0.621206
      0.137723
      0.148328
      0.140719
      0.0
      0.140719
      0.266187
      0.400000
      0.706186
      0.334928
      0.135086
      0.218656
      1.000000
      0.878793
      0.656104
      0.840000
      0.0
      0.286919
      0.323835
      0.287354
      0.384461
      0.407314
      0.347305
      0.0
      0.347305
      0.350719
      0.000000
      0.368557
      0.362440
      0.391198
      0.270812
      0.000000
      0.243974
      0.306151
      0.357500
    
    
      135
      RRBS_normal_B_cell_H1_22_TAGGCATG.TCTCTG
      0.0
      0.560233
      0.366567
      0.591090
      0.120401
      0.128137
      0.182218
      0.0
      0.182218
      0.329330
      0.558873
      0.703213
      0.278496
      0.111726
      0.241188
      0.930269
      0.887614
      0.628778
      0.865630
      0.0
      0.276382
      0.338157
      0.268336
      0.360595
      0.380319
      0.401676
      0.0
      0.401676
      0.369472
      0.293523
      0.278300
      0.314054
      0.366833
      0.346789
      0.255155
      0.244022
      0.313503
      0.248764
    
  








    



In [11] used 0.023 MiB RAM in 0.107s, peaked 0.000 MiB above current, total RAM usage 104.242 MiB



In [12]:

    
pcell["protocol"] = pcell["filename"].str[:31]









    



In [12] used 0.004 MiB RAM in 0.003s, peaked 0.000 MiB above current, total RAM usage 104.246 MiB



In [13]:

    
pcell["filename"][pcell["protocol"]=='RRBS_NormalBCD19pCD27pcell1_22_'] = pcell["filename"].str[:46]
pcell["filename"][pcell["protocol"]=='RRBS_NormalBCD19pCD27pcell23_44'] = pcell["filename"].str[:47]
pcell["filename"][pcell["protocol"]=='RRBS_NormalBCD19pCD27pcell45_66'] = pcell["filename"].str[:47]
pcell["filename"][pcell["protocol"]=='RRBS_NormalBCD19pCD27pcell67_88'] = pcell["filename"].str[:47]









    



/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:1: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  if __name__ == '__main__':
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:2: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  from ipykernel import kernelapp as app
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:3: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  app.launch_new_instance()
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:4: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy






    



In [13] used 0.109 MiB RAM in 0.249s, peaked 0.000 MiB above current, total RAM usage 104.355 MiB



In [14]:

    
pcell.tail()









    Out[14]:






  
    
      
      filename
      methylation_tssDistance
      methylation_genesDistance
      methylation_exonsDistance
      methylation_intronsDistance
      methylation_promoterDistance
      methylation_cgiDistance
      methylation_ctcfDistance
      methylation_ctcfUpDistance
      methylation_ctcfDownDistance
      methylation_geneDistalRegulatoryModulesDistance
      methylation_vistaEnhancersDistance
      methylation_3PrimeUTRDistance
      methylation_5PrimeUTRDistance
      methylation_firstExonDistance
      methylation_geneDistalRegulatoryModulesK562Distance
      methylation_hypoInHues64Distance
      methylation_intergenic
      methylation_shore
      methylation_shelf
      PDR_tssDistance
      PDR_genesDistance
      PDR_exonsDistance
      PDR_intronsDistance
      PDR_promoterDistance
      PDR_cgiDistance
      PDR_ctcfDistance
      PDR_ctcfUpDistance
      PDR_ctcfDownDistance
      PDR_geneDistalRegulatoryModulesDistance
      PDR_vistaEnhancersDistance
      PDR_3PrimeUTRDistance
      PDR_5PrimeUTRDistance
      PDR_firstExonDistance
      PDR_geneDistalRegulatoryModulesK562Distance
      PDR_hypoInHues64Distance
      PDR_intergenic
      PDR_shore
      PDR_shelf
      protocol
    
  
  
    
      85
      RRBS_NormalBCD19pCD27pcell67_88_GCTACGCT.GTTGAG
      0.0
      0.488591
      0.320965
      0.515461
      0.090361
      0.105259
      0.121025
      0.0
      0.121025
      0.263410
      0.516635
      0.618186
      0.232372
      0.087691
      0.179349
      0.855401
      0.786055
      0.541282
      0.773497
      0.0
      0.281265
      0.250894
      0.285832
      0.152622
      0.193308
      0.192678
      0.0
      0.192678
      0.276641
      0.645913
      0.369431
      0.183830
      0.159538
      0.183626
      0.488850
      0.429191
      0.356704
      0.371891
      RRBS_NormalBCD19pCD27pcell67_88
    
    
      86
      RRBS_NormalBCD19pCD27pcell67_88_GCTACGCT.TAGCGG
      0.0
      0.482284
      0.313186
      0.509034
      0.085526
      0.094721
      0.126048
      0.0
      0.126048
      0.258379
      0.331160
      0.603295
      0.229917
      0.074569
      0.173552
      0.891344
      0.781317
      0.519032
      0.765147
      0.0
      0.275113
      0.244301
      0.281934
      0.159508
      0.186889
      0.213556
      0.0
      0.213556
      0.284529
      0.364407
      0.374666
      0.194492
      0.150189
      0.202991
      0.220994
      0.416715
      0.372722
      0.386118
      RRBS_NormalBCD19pCD27pcell67_88
    
    
      87
      RRBS_NormalBCD19pCD27pcell67_88_GCTACGCT.TATCTC
      0.0
      0.486434
      0.337771
      0.509877
      0.104169
      0.131287
      0.145222
      0.0
      0.145222
      0.275499
      0.528938
      0.594743
      0.239506
      0.108890
      0.177779
      0.812648
      0.734134
      0.536591
      0.741314
      0.0
      0.317291
      0.273234
      0.322569
      0.168070
      0.214958
      0.197274
      0.0
      0.197274
      0.298599
      0.433302
      0.385105
      0.203708
      0.181556
      0.193979
      0.399823
      0.492227
      0.388837
      0.420926
      RRBS_NormalBCD19pCD27pcell67_88
    
    
      88
      RRBS_NormalBCD19pCD27pcell67_88_GCTACGCT.TCTCTG
      0.0
      0.504985
      0.354574
      0.527785
      0.126590
      0.162859
      0.148021
      0.0
      0.148021
      0.298728
      0.675342
      0.654135
      0.247424
      0.123843
      0.198148
      0.793358
      0.753129
      0.541053
      0.740954
      0.0
      0.308032
      0.268731
      0.311831
      0.174724
      0.213951
      0.206692
      0.0
      0.206692
      0.310745
      0.335160
      0.390648
      0.196147
      0.168175
      0.209597
      0.402829
      0.469717
      0.383694
      0.375906
      RRBS_NormalBCD19pCD27pcell67_88
    
    
      89
      RRBS_NormalBCD19pCD27pcell67_88_GCTACGCT.TGCTGC
      0.0
      0.461103
      0.285016
      0.490647
      0.061652
      0.073687
      0.091623
      0.0
      0.091623
      0.224748
      0.583333
      0.622024
      0.196912
      0.058647
      0.151447
      1.000000
      0.882502
      0.575498
      0.874932
      0.0
      0.166791
      0.159804
      0.165718
      0.099319
      0.130943
      0.126309
      0.0
      0.126309
      0.179091
      0.083333
      0.245536
      0.094161
      0.100645
      0.120579
      0.000000
      0.205599
      0.257229
      0.231186
      RRBS_NormalBCD19pCD27pcell67_88
    
  








    



In [14] used 0.035 MiB RAM in 0.074s, peaked 0.000 MiB above current, total RAM usage 104.391 MiB



In [15]:

    
mcell["protocol"] = mcell["filename"].str[:31]









    



In [15] used 0.016 MiB RAM in 0.002s, peaked 0.000 MiB above current, total RAM usage 104.406 MiB



In [16]:

    
mcell["filename"][mcell["protocol"]=='RRBS_NormalBCD19pCD27mcell1_22_'] = mcell["filename"].str[:46]
mcell["filename"][mcell["protocol"]=='RRBS_NormalBCD19pCD27mcell23_44'] = mcell["filename"].str[:47]
mcell["filename"][mcell["protocol"]=='RRBS_NormalBCD19pCD27mcell45_66'] = mcell["filename"].str[:47]
mcell["filename"][mcell["protocol"]=='RRBS_NormalBCD19pCD27mcell67_88'] = mcell["filename"].str[:47]









    



/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:1: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  if __name__ == '__main__':
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:2: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  from ipykernel import kernelapp as app
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:3: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  app.launch_new_instance()
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:4: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy






    



In [16] used 0.035 MiB RAM in 0.244s, peaked 0.000 MiB above current, total RAM usage 104.441 MiB



In [17]:

    
mcell.tail()









    Out[17]:






  
    
      
      filename
      methylation_tssDistance
      methylation_genesDistance
      methylation_exonsDistance
      methylation_intronsDistance
      methylation_promoterDistance
      methylation_cgiDistance
      methylation_ctcfDistance
      methylation_ctcfUpDistance
      methylation_ctcfDownDistance
      methylation_geneDistalRegulatoryModulesDistance
      methylation_vistaEnhancersDistance
      methylation_3PrimeUTRDistance
      methylation_5PrimeUTRDistance
      methylation_firstExonDistance
      methylation_geneDistalRegulatoryModulesK562Distance
      methylation_hypoInHues64Distance
      methylation_intergenic
      methylation_shore
      methylation_shelf
      PDR_tssDistance
      PDR_genesDistance
      PDR_exonsDistance
      PDR_intronsDistance
      PDR_promoterDistance
      PDR_cgiDistance
      PDR_ctcfDistance
      PDR_ctcfUpDistance
      PDR_ctcfDownDistance
      PDR_geneDistalRegulatoryModulesDistance
      PDR_vistaEnhancersDistance
      PDR_3PrimeUTRDistance
      PDR_5PrimeUTRDistance
      PDR_firstExonDistance
      PDR_geneDistalRegulatoryModulesK562Distance
      PDR_hypoInHues64Distance
      PDR_intergenic
      PDR_shore
      PDR_shelf
      protocol
    
  
  
    
      83
      RRBS_NormalBCD19pCD27mcell67_88_CGTACTAG.GTGAGG
      0.0
      0.472029
      0.279894
      0.507985
      0.062184
      0.068979
      0.099081
      0.0
      0.099081
      0.254673
      0.414678
      0.646722
      0.202133
      0.052964
      0.180330
      0.825413
      0.880407
      0.567798
      0.868663
      0.0
      0.162036
      0.157993
      0.162275
      0.105846
      0.134560
      0.144832
      0.0
      0.144832
      0.210529
      0.343079
      0.229286
      0.102900
      0.115445
      0.160677
      0.270661
      0.208397
      0.252791
      0.195733
      RRBS_NormalBCD19pCD27mcell67_88
    
    
      84
      RRBS_NormalBCD19pCD27mcell67_88_CGTACTAG.GTTGAG
      0.0
      0.475509
      0.284108
      0.507053
      0.067481
      0.074098
      0.107121
      0.0
      0.107121
      0.252745
      0.376858
      0.661143
      0.200471
      0.058478
      0.178968
      0.852344
      0.884411
      0.593522
      0.879363
      0.0
      0.157373
      0.152483
      0.156989
      0.105841
      0.133327
      0.140077
      0.0
      0.140077
      0.195673
      0.159236
      0.214858
      0.102166
      0.103687
      0.136311
      0.139063
      0.208999
      0.275148
      0.201310
      RRBS_NormalBCD19pCD27mcell67_88
    
    
      85
      RRBS_NormalBCD19pCD27mcell67_88_CGTACTAG.TAGCGG
      0.0
      0.465384
      0.270854
      0.497950
      0.070138
      0.075311
      0.113918
      0.0
      0.113918
      0.265460
      0.515006
      0.626513
      0.197863
      0.054605
      0.191544
      0.873469
      0.874056
      0.568923
      0.844443
      0.0
      0.165017
      0.151922
      0.166105
      0.117741
      0.146015
      0.161420
      0.0
      0.161420
      0.211532
      0.650660
      0.257800
      0.104910
      0.104068
      0.157382
      0.273469
      0.210667
      0.270156
      0.202981
      RRBS_NormalBCD19pCD27mcell67_88
    
    
      86
      RRBS_NormalBCD19pCD27mcell67_88_CGTACTAG.TATCTC
      0.0
      0.475148
      0.283056
      0.509076
      0.067527
      0.076951
      0.117951
      0.0
      0.117951
      0.258988
      0.298264
      0.644925
      0.206166
      0.057636
      0.178186
      0.948181
      0.881155
      0.586620
      0.867445
      0.0
      0.160243
      0.152014
      0.161938
      0.115076
      0.146481
      0.159352
      0.0
      0.159352
      0.204830
      0.377937
      0.193244
      0.110812
      0.107856
      0.135752
      0.152150
      0.215250
      0.266874
      0.199644
      RRBS_NormalBCD19pCD27mcell67_88
    
    
      87
      RRBS_NormalBCD19pCD27mcell67_88_CGTACTAG.TCTCTG
      0.0
      0.428225
      0.251018
      0.461970
      0.061715
      0.068326
      0.092568
      0.0
      0.092568
      0.211492
      0.450980
      0.630726
      0.171360
      0.056249
      0.140668
      0.892283
      0.877888
      0.557980
      0.854488
      0.0
      0.159956
      0.156530
      0.159670
      0.108323
      0.135232
      0.156855
      0.0
      0.156855
      0.199040
      0.287582
      0.263901
      0.103231
      0.117227
      0.144726
      0.075563
      0.210384
      0.254628
      0.219492
      RRBS_NormalBCD19pCD27mcell67_88
    
  








    



In [17] used -0.090 MiB RAM in 0.070s, peaked 0.090 MiB above current, total RAM usage 104.352 MiB



In [18]:

    
len("RRBS_NormalBCD19pcell1_22_")









    Out[18]:





26






    



In [18] used 0.000 MiB RAM in 0.002s, peaked 0.000 MiB above current, total RAM usage 104.352 MiB



In [19]:

    
cd19cell["protocol"] = cd19cell["filename"].str[:26]









    



In [19] used 0.016 MiB RAM in 0.003s, peaked 0.000 MiB above current, total RAM usage 104.367 MiB



In [20]:

    
len('RRBS_NormalBCD19pcell1_22_TAAGGCGA.ACAACC')









    Out[20]:





41






    



In [20] used 0.016 MiB RAM in 0.003s, peaked 0.000 MiB above current, total RAM usage 104.383 MiB



In [21]:

    
cd19cell["filename"][cd19cell["protocol"]=='RRBS_NormalBCD19pcell1_22_'] = cd19cell["filename"].str[:41]
cd19cell["filename"][cd19cell["protocol"]=='RRBS_NormalBCD19pcell23_44'] = cd19cell["filename"].str[:42]
cd19cell["filename"][cd19cell["protocol"]=='RRBS_NormalBCD19pcell45_66'] = cd19cell["filename"].str[:42]
cd19cell["filename"][cd19cell["protocol"]=='RRBS_NormalBCD19pcell67_88'] = cd19cell["filename"].str[:42]









    



/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:1: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  if __name__ == '__main__':
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:2: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  from ipykernel import kernelapp as app
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:3: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  app.launch_new_instance()
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:4: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy






    



In [21] used 0.023 MiB RAM in 0.252s, peaked 0.000 MiB above current, total RAM usage 104.406 MiB



In [22]:

    
cd19cell.tail()









    Out[22]:






  
    
      
      filename
      methylation_tssDistance
      methylation_genesDistance
      methylation_exonsDistance
      methylation_intronsDistance
      methylation_promoterDistance
      methylation_cgiDistance
      methylation_ctcfDistance
      methylation_ctcfUpDistance
      methylation_ctcfDownDistance
      methylation_geneDistalRegulatoryModulesDistance
      methylation_vistaEnhancersDistance
      methylation_3PrimeUTRDistance
      methylation_5PrimeUTRDistance
      methylation_firstExonDistance
      methylation_geneDistalRegulatoryModulesK562Distance
      methylation_hypoInHues64Distance
      methylation_intergenic
      methylation_shore
      methylation_shelf
      PDR_tssDistance
      PDR_genesDistance
      PDR_exonsDistance
      PDR_intronsDistance
      PDR_promoterDistance
      PDR_cgiDistance
      PDR_ctcfDistance
      PDR_ctcfUpDistance
      PDR_ctcfDownDistance
      PDR_geneDistalRegulatoryModulesDistance
      PDR_vistaEnhancersDistance
      PDR_3PrimeUTRDistance
      PDR_5PrimeUTRDistance
      PDR_firstExonDistance
      PDR_geneDistalRegulatoryModulesK562Distance
      PDR_hypoInHues64Distance
      PDR_intergenic
      PDR_shore
      PDR_shelf
      protocol
    
  
  
    
      84
      RRBS_NormalBCD19pcell67_88_TCCTGAGC.GTTGAG
      0.0
      0.365003
      0.198154
      0.403464
      0.045692
      0.049036
      0.067145
      0.0
      0.067145
      0.175783
      0.170213
      0.603492
      0.133213
      0.039203
      0.124610
      0.990164
      0.857586
      0.529461
      0.830424
      0.0
      0.151630
      0.135355
      0.155304
      0.086338
      0.115382
      0.124663
      0.0
      0.124663
      0.173466
      0.045593
      0.233981
      0.088479
      0.087266
      0.128772
      0.000000
      0.238726
      0.295577
      0.208543
      RRBS_NormalBCD19pcell67_88
    
    
      85
      RRBS_NormalBCD19pcell67_88_TCCTGAGC.TAGCGG
      0.0
      0.427826
      0.249504
      0.457398
      0.062149
      0.072737
      0.087771
      0.0
      0.087771
      0.207407
      0.428877
      0.564334
      0.176146
      0.050720
      0.137381
      0.662519
      0.804080
      0.516266
      0.779332
      0.0
      0.224285
      0.181686
      0.230307
      0.109675
      0.134092
      0.141826
      0.0
      0.141826
      0.200233
      0.200000
      0.300089
      0.122736
      0.101102
      0.129729
      0.395023
      0.371977
      0.332454
      0.371777
      RRBS_NormalBCD19pcell67_88
    
    
      86
      RRBS_NormalBCD19pcell67_88_TCCTGAGC.TATCTC
      0.0
      0.424818
      0.246150
      0.456708
      0.058898
      0.070105
      0.105839
      0.0
      0.105839
      0.221580
      0.363380
      0.632963
      0.176894
      0.050543
      0.149377
      0.885320
      0.825866
      0.539768
      0.819517
      0.0
      0.195755
      0.165491
      0.200067
      0.101588
      0.130197
      0.151039
      0.0
      0.151039
      0.215342
      0.302535
      0.281348
      0.112925
      0.096018
      0.148490
      0.410017
      0.335954
      0.310619
      0.307484
      RRBS_NormalBCD19pcell67_88
    
    
      87
      RRBS_NormalBCD19pcell67_88_TCCTGAGC.TCTCTG
      0.0
      0.472135
      0.286358
      0.503827
      0.066952
      0.077275
      0.107918
      0.0
      0.107918
      0.244037
      0.413347
      0.619841
      0.199015
      0.058952
      0.168218
      0.894972
      0.879557
      0.591964
      0.864421
      0.0
      0.157952
      0.150639
      0.158441
      0.108958
      0.132628
      0.156623
      0.0
      0.156623
      0.199528
      0.254980
      0.243718
      0.096941
      0.102134
      0.130035
      0.138547
      0.206872
      0.276050
      0.196075
      RRBS_NormalBCD19pcell67_88
    
    
      88
      RRBS_NormalBCD19pcell67_88_TCCTGAGC.TGCTGC
      0.0
      0.386120
      0.188577
      0.424230
      0.057304
      0.069063
      0.110272
      0.0
      0.110272
      0.226848
      0.000000
      0.601695
      0.166264
      0.051560
      0.174515
      0.933333
      0.866931
      0.560803
      0.818182
      0.0
      0.167532
      0.149592
      0.180484
      0.103296
      0.120248
      0.193353
      0.0
      0.193353
      0.230246
      0.000000
      0.152542
      0.106332
      0.105665
      0.193906
      0.466667
      0.299404
      0.284534
      0.258182
      RRBS_NormalBCD19pcell67_88
    
  








    



In [22] used 0.020 MiB RAM in 0.076s, peaked 0.000 MiB above current, total RAM usage 104.426 MiB



In [23]:

    
len("RRBS_cw154_Tris_protease_GR")









    Out[23]:





27






    



In [23] used 0.016 MiB RAM in 0.004s, peaked 0.000 MiB above current, total RAM usage 104.441 MiB



In [24]:

    
cw154["protocol"] = cw154["filename"].str[:27]









    



In [24] used 0.016 MiB RAM in 0.003s, peaked 0.000 MiB above current, total RAM usage 104.457 MiB



In [25]:

    
cw154.head()  # RRBS_cw154_CutSmart_protein   # RRBS_cw154_Tris_protease_CT   # RRBS_cw154_Tris_protease_GR









    Out[25]:






  
    
      
      filename
      methylation_tssDistance
      methylation_genesDistance
      methylation_exonsDistance
      methylation_intronsDistance
      methylation_promoterDistance
      methylation_cgiDistance
      methylation_ctcfDistance
      methylation_ctcfUpDistance
      methylation_ctcfDownDistance
      methylation_geneDistalRegulatoryModulesDistance
      methylation_vistaEnhancersDistance
      methylation_3PrimeUTRDistance
      methylation_5PrimeUTRDistance
      methylation_firstExonDistance
      methylation_geneDistalRegulatoryModulesK562Distance
      methylation_hypoInHues64Distance
      methylation_intergenic
      methylation_shore
      methylation_shelf
      PDR_tssDistance
      PDR_genesDistance
      PDR_exonsDistance
      PDR_intronsDistance
      PDR_promoterDistance
      PDR_cgiDistance
      PDR_ctcfDistance
      PDR_ctcfUpDistance
      PDR_ctcfDownDistance
      PDR_geneDistalRegulatoryModulesDistance
      PDR_vistaEnhancersDistance
      PDR_3PrimeUTRDistance
      PDR_5PrimeUTRDistance
      PDR_firstExonDistance
      PDR_geneDistalRegulatoryModulesK562Distance
      PDR_hypoInHues64Distance
      PDR_intergenic
      PDR_shore
      PDR_shelf
      protocol
    
  
  
    
      0
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACAA...
      0.0
      0.557445
      0.387638
      0.583685
      0.148984
      0.173551
      0.197546
      0.0
      0.197546
      0.330378
      0.534917
      0.659609
      0.300969
      0.142909
      0.246735
      0.805699
      0.820512
      0.590658
      0.806973
      0.0
      0.370149
      0.420504
      0.359511
      0.408136
      0.450911
      0.436709
      0.0
      0.436709
      0.446102
      0.393463
      0.409348
      0.376109
      0.438725
      0.388377
      0.397393
      0.379858
      0.378600
      0.345222
      RRBS_cw154_CutSmart_protein
    
    
      1
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACCG...
      0.0
      0.495537
      0.324467
      0.521993
      0.140566
      0.157658
      0.175575
      0.0
      0.175575
      0.296219
      0.366917
      0.587535
      0.261936
      0.137202
      0.237040
      0.690698
      0.796567
      0.530634
      0.780923
      0.0
      0.388093
      0.435418
      0.383256
      0.418755
      0.458484
      0.442186
      0.0
      0.442186
      0.440632
      0.840602
      0.376294
      0.386659
      0.445932
      0.394716
      0.346512
      0.418598
      0.404386
      0.362456
      RRBS_cw154_CutSmart_protein
    
    
      2
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACGT...
      0.0
      0.520409
      0.357209
      0.544602
      0.138190
      0.161856
      0.202110
      0.0
      0.202110
      0.314849
      0.463004
      0.656101
      0.275719
      0.138640
      0.225783
      0.761359
      0.792970
      0.551861
      0.785731
      0.0
      0.383971
      0.430167
      0.374988
      0.410647
      0.455464
      0.453277
      0.0
      0.453277
      0.450694
      0.324865
      0.443011
      0.387172
      0.439933
      0.414011
      0.280260
      0.411414
      0.389000
      0.363575
      RRBS_cw154_CutSmart_protein
    
    
      3
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACTC...
      0.0
      0.569906
      0.398614
      0.595372
      0.158028
      0.178889
      0.196911
      0.0
      0.196911
      0.340942
      0.608100
      0.665446
      0.310607
      0.154927
      0.247978
      0.867355
      0.831256
      0.609382
      0.812445
      0.0
      0.363173
      0.416487
      0.354378
      0.421272
      0.454977
      0.438265
      0.0
      0.438265
      0.452257
      0.477332
      0.376957
      0.382624
      0.449764
      0.400321
      0.171406
      0.369736
      0.385435
      0.345905
      RRBS_cw154_CutSmart_protein
    
    
      4
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.AGGA...
      0.0
      0.554293
      0.390193
      0.576205
      0.148946
      0.173784
      0.194668
      0.0
      0.194668
      0.339245
      0.494894
      0.652036
      0.291318
      0.145185
      0.250083
      0.894932
      0.825017
      0.592558
      0.807747
      0.0
      0.365658
      0.414198
      0.357211
      0.407138
      0.447926
      0.433596
      0.0
      0.433596
      0.428716
      0.406863
      0.397655
      0.376272
      0.425466
      0.383864
      0.274772
      0.382212
      0.378352
      0.346732
      RRBS_cw154_CutSmart_protein
    
  








    



In [25] used -0.004 MiB RAM in 0.067s, peaked 0.004 MiB above current, total RAM usage 104.453 MiB



In [26]:

    
cw154["filename"][cw154["protocol"] == "RRBS_cw154_CutSmart_protein"] = cw154["filename"].str[:48]
cw154["filename"][cw154["protocol"] == "RRBS_cw154_Tris_protease_CT"] = cw154["filename"].str[:40]
cw154["filename"][cw154["protocol"] == "RRBS_cw154_Tris_protease_GR"] = cw154["filename"].str[:43]









    



In [26] used 0.012 MiB RAM in 0.172s, peaked 0.000 MiB above current, total RAM usage 104.465 MiB






    



/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:1: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  if __name__ == '__main__':
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:2: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  from ipykernel import kernelapp as app
/opt/local/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/ipykernel/__main__.py:3: SettingWithCopyWarning: 
A value is trying to be set on a copy of a slice from a DataFrame

See the caveats in the documentation: http://pandas.pydata.org/pandas-docs/stable/indexing.html#indexing-view-versus-copy
  app.launch_new_instance()



In [27]:

    
cw154









    Out[27]:






  
    
      
      filename
      methylation_tssDistance
      methylation_genesDistance
      methylation_exonsDistance
      methylation_intronsDistance
      methylation_promoterDistance
      methylation_cgiDistance
      methylation_ctcfDistance
      methylation_ctcfUpDistance
      methylation_ctcfDownDistance
      methylation_geneDistalRegulatoryModulesDistance
      methylation_vistaEnhancersDistance
      methylation_3PrimeUTRDistance
      methylation_5PrimeUTRDistance
      methylation_firstExonDistance
      methylation_geneDistalRegulatoryModulesK562Distance
      methylation_hypoInHues64Distance
      methylation_intergenic
      methylation_shore
      methylation_shelf
      PDR_tssDistance
      PDR_genesDistance
      PDR_exonsDistance
      PDR_intronsDistance
      PDR_promoterDistance
      PDR_cgiDistance
      PDR_ctcfDistance
      PDR_ctcfUpDistance
      PDR_ctcfDownDistance
      PDR_geneDistalRegulatoryModulesDistance
      PDR_vistaEnhancersDistance
      PDR_3PrimeUTRDistance
      PDR_5PrimeUTRDistance
      PDR_firstExonDistance
      PDR_geneDistalRegulatoryModulesK562Distance
      PDR_hypoInHues64Distance
      PDR_intergenic
      PDR_shore
      PDR_shelf
      protocol
    
  
  
    
      0
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACAACC
      0.0
      0.557445
      0.387638
      0.583685
      0.148984
      0.173551
      0.197546
      0.0
      0.197546
      0.330378
      0.534917
      0.659609
      0.300969
      0.142909
      0.246735
      0.805699
      0.820512
      0.590658
      0.806973
      0.0
      0.370149
      0.420504
      0.359511
      0.408136
      0.450911
      0.436709
      0.0
      0.436709
      0.446102
      0.393463
      0.409348
      0.376109
      0.438725
      0.388377
      0.397393
      0.379858
      0.378600
      0.345222
      RRBS_cw154_CutSmart_protein
    
    
      1
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACCGCG
      0.0
      0.495537
      0.324467
      0.521993
      0.140566
      0.157658
      0.175575
      0.0
      0.175575
      0.296219
      0.366917
      0.587535
      0.261936
      0.137202
      0.237040
      0.690698
      0.796567
      0.530634
      0.780923
      0.0
      0.388093
      0.435418
      0.383256
      0.418755
      0.458484
      0.442186
      0.0
      0.442186
      0.440632
      0.840602
      0.376294
      0.386659
      0.445932
      0.394716
      0.346512
      0.418598
      0.404386
      0.362456
      RRBS_cw154_CutSmart_protein
    
    
      2
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACGTGG
      0.0
      0.520409
      0.357209
      0.544602
      0.138190
      0.161856
      0.202110
      0.0
      0.202110
      0.314849
      0.463004
      0.656101
      0.275719
      0.138640
      0.225783
      0.761359
      0.792970
      0.551861
      0.785731
      0.0
      0.383971
      0.430167
      0.374988
      0.410647
      0.455464
      0.453277
      0.0
      0.453277
      0.450694
      0.324865
      0.443011
      0.387172
      0.439933
      0.414011
      0.280260
      0.411414
      0.389000
      0.363575
      RRBS_cw154_CutSmart_protein
    
    
      3
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACTCAC
      0.0
      0.569906
      0.398614
      0.595372
      0.158028
      0.178889
      0.196911
      0.0
      0.196911
      0.340942
      0.608100
      0.665446
      0.310607
      0.154927
      0.247978
      0.867355
      0.831256
      0.609382
      0.812445
      0.0
      0.363173
      0.416487
      0.354378
      0.421272
      0.454977
      0.438265
      0.0
      0.438265
      0.452257
      0.477332
      0.376957
      0.382624
      0.449764
      0.400321
      0.171406
      0.369736
      0.385435
      0.345905
      RRBS_cw154_CutSmart_protein
    
    
      4
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.AGGATG
      0.0
      0.554293
      0.390193
      0.576205
      0.148946
      0.173784
      0.194668
      0.0
      0.194668
      0.339245
      0.494894
      0.652036
      0.291318
      0.145185
      0.250083
      0.894932
      0.825017
      0.592558
      0.807747
      0.0
      0.365658
      0.414198
      0.357211
      0.407138
      0.447926
      0.433596
      0.0
      0.433596
      0.428716
      0.406863
      0.397655
      0.376272
      0.425466
      0.383864
      0.274772
      0.382212
      0.378352
      0.346732
      RRBS_cw154_CutSmart_protein
    
    
      5
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ATAGCG
      0.0
      0.526884
      0.365643
      0.552338
      0.136827
      0.156219
      0.186982
      0.0
      0.186982
      0.301051
      0.415511
      0.644089
      0.271955
      0.138062
      0.216288
      0.857859
      0.811758
      0.577252
      0.782210
      0.0
      0.367963
      0.412391
      0.359439
      0.403460
      0.439426
      0.423300
      0.0
      0.423300
      0.429729
      0.292245
      0.380568
      0.375672
      0.428114
      0.370678
      0.322551
      0.389826
      0.380924
      0.350955
      RRBS_cw154_CutSmart_protein
    
    
      6
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ATCGAC
      0.0
      0.565536
      0.398508
      0.589354
      0.153438
      0.180336
      0.206914
      0.0
      0.206914
      0.347903
      0.522757
      0.669365
      0.309018
      0.148969
      0.258009
      0.820103
      0.819525
      0.596228
      0.804310
      0.0
      0.369158
      0.418102
      0.361217
      0.417424
      0.458302
      0.448756
      0.0
      0.448756
      0.443698
      0.440532
      0.368417
      0.382661
      0.443897
      0.395646
      0.354083
      0.387312
      0.389256
      0.340801
      RRBS_cw154_CutSmart_protein
    
    
      7
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.CAAGAG
      0.0
      0.547472
      0.384373
      0.572749
      0.152863
      0.174421
      0.196066
      0.0
      0.196066
      0.323417
      0.597436
      0.672153
      0.293574
      0.158459
      0.240607
      0.824585
      0.818860
      0.588054
      0.798634
      0.0
      0.376000
      0.434308
      0.366559
      0.423294
      0.459171
      0.451662
      0.0
      0.451662
      0.447380
      0.488112
      0.390544
      0.391449
      0.454109
      0.397710
      0.296812
      0.377959
      0.384896
      0.350755
      RRBS_cw154_CutSmart_protein
    
    
      8
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.CATGAC
      0.0
      0.560115
      0.399275
      0.582994
      0.152070
      0.177982
      0.210642
      0.0
      0.210642
      0.340830
      0.435017
      0.658850
      0.302575
      0.158123
      0.251308
      0.843652
      0.824098
      0.590612
      0.803914
      0.0
      0.373358
      0.424900
      0.366055
      0.417887
      0.459681
      0.468793
      0.0
      0.468793
      0.450033
      0.352024
      0.396828
      0.387961
      0.445253
      0.403604
      0.319329
      0.384551
      0.390295
      0.359863
      RRBS_cw154_CutSmart_protein
    
    
      9
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.CCTTCG
      0.0
      0.532219
      0.373563
      0.554328
      0.142907
      0.169012
      0.183736
      0.0
      0.183736
      0.302616
      0.550507
      0.615149
      0.286602
      0.137620
      0.221478
      0.836297
      0.797139
      0.569496
      0.783430
      0.0
      0.385187
      0.431739
      0.377812
      0.418669
      0.460034
      0.465381
      0.0
      0.465381
      0.453603
      0.594966
      0.418134
      0.380153
      0.439284
      0.396606
      0.339958
      0.408284
      0.396687
      0.369618
      RRBS_cw154_CutSmart_protein
    
    
      10
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.CGGTAG
      0.0
      0.531700
      0.370532
      0.555725
      0.143834
      0.165315
      0.196658
      0.0
      0.196658
      0.309425
      0.623132
      0.622519
      0.289789
      0.155198
      0.227672
      0.843004
      0.805881
      0.560993
      0.780727
      0.0
      0.382102
      0.430692
      0.375433
      0.424467
      0.459925
      0.446492
      0.0
      0.446492
      0.438186
      0.285556
      0.395191
      0.396617
      0.457859
      0.385372
      0.288365
      0.385553
      0.395152
      0.348968
      RRBS_cw154_CutSmart_protein
    
    
      11
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.CTATTG
      0.0
      0.000000
      0.438795
      0.584559
      0.167596
      0.132262
      0.247382
      0.0
      0.247382
      0.367269
      0.666667
      0.802508
      0.266462
      0.184211
      0.438384
      NaN
      0.864040
      0.753557
      0.898721
      0.0
      0.320416
      0.364490
      0.306668
      0.356688
      0.364810
      0.492147
      0.0
      0.492147
      0.336617
      1.000000
      0.278997
      0.367534
      0.408669
      0.282828
      0.000000
      0.255152
      0.306773
      0.166311
      RRBS_cw154_CutSmart_protein
    
    
      12
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.CTCAGC
      0.0
      0.541012
      0.377389
      0.563507
      0.145227
      0.168764
      0.192585
      0.0
      0.192585
      0.316389
      0.499417
      0.620360
      0.294856
      0.143099
      0.234895
      0.807127
      0.815787
      0.578767
      0.792081
      0.0
      0.376073
      0.421432
      0.367262
      0.419961
      0.462968
      0.441023
      0.0
      0.441023
      0.437581
      0.588098
      0.388470
      0.389301
      0.439037
      0.393979
      0.358086
      0.389474
      0.390579
      0.352459
      RRBS_cw154_CutSmart_protein
    
    
      13
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.GACACG
      0.0
      0.539446
      0.379285
      0.562106
      0.151057
      0.169830
      0.197479
      0.0
      0.197479
      0.319023
      0.526829
      0.624394
      0.298679
      0.152752
      0.245067
      0.817265
      0.808146
      0.560909
      0.785910
      0.0
      0.383113
      0.442335
      0.372629
      0.432990
      0.474104
      0.484110
      0.0
      0.484110
      0.456716
      0.394038
      0.435484
      0.392065
      0.465344
      0.397636
      0.453005
      0.394112
      0.399016
      0.354612
      RRBS_cw154_CutSmart_protein
    
    
      14
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.GCATTC
      0.0
      0.573906
      0.406627
      0.598475
      0.155752
      0.181375
      0.219125
      0.0
      0.219125
      0.349142
      0.461636
      0.692945
      0.314043
      0.149229
      0.265561
      0.805184
      0.818499
      0.600889
      0.805211
      0.0
      0.364838
      0.413731
      0.355293
      0.418106
      0.451039
      0.460955
      0.0
      0.460955
      0.439120
      0.427394
      0.374650
      0.384259
      0.436755
      0.386565
      0.237381
      0.388799
      0.388247
      0.351250
      RRBS_cw154_CutSmart_protein
    
    
      15
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.GCTGCC
      0.0
      0.539193
      0.372853
      0.564383
      0.150046
      0.168813
      0.200850
      0.0
      0.200850
      0.317655
      0.268741
      0.630294
      0.293949
      0.147488
      0.230698
      0.821040
      0.793269
      0.565109
      0.775614
      0.0
      0.393342
      0.452026
      0.385192
      0.444778
      0.484272
      0.488233
      0.0
      0.488233
      0.459993
      0.214993
      0.453466
      0.409531
      0.469308
      0.402897
      0.556227
      0.403487
      0.399105
      0.359500
      RRBS_cw154_CutSmart_protein
    
    
      16
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.GGCATC
      0.0
      0.548961
      0.381545
      0.572243
      0.146518
      0.163592
      0.183910
      0.0
      0.183910
      0.332055
      0.649764
      0.659449
      0.302050
      0.137127
      0.242075
      0.858011
      0.802843
      0.573498
      0.788575
      0.0
      0.369289
      0.415335
      0.362727
      0.408150
      0.450432
      0.434240
      0.0
      0.434240
      0.448769
      0.330582
      0.427089
      0.369247
      0.423437
      0.403369
      0.205525
      0.403571
      0.402985
      0.363866
      RRBS_cw154_CutSmart_protein
    
    
      17
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.GTGAGG
      0.0
      0.517231
      0.360581
      0.541139
      0.144744
      0.169206
      0.192751
      0.0
      0.192751
      0.305701
      0.480723
      0.644707
      0.272439
      0.143972
      0.224896
      0.918484
      0.809293
      0.549385
      0.774150
      0.0
      0.384798
      0.440085
      0.375126
      0.427821
      0.470287
      0.458102
      0.0
      0.458102
      0.450411
      0.491777
      0.418309
      0.398621
      0.454455
      0.393129
      0.153117
      0.377603
      0.389681
      0.372192
      RRBS_cw154_CutSmart_protein
    
    
      18
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.GTTGAG
      0.0
      0.445185
      0.314814
      0.459320
      0.101895
      0.106513
      0.175696
      0.0
      0.175696
      0.255117
      0.000000
      0.678481
      0.205315
      0.121112
      0.152685
      1.000000
      0.864037
      0.541609
      0.803819
      0.0
      0.289698
      0.302033
      0.274471
      0.305291
      0.323511
      0.320269
      0.0
      0.320269
      0.332025
      0.000000
      0.272405
      0.287926
      0.304364
      0.244743
      0.000000
      0.259456
      0.350199
      0.261936
      RRBS_cw154_CutSmart_protein
    
    
      19
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.TAGCGG
      0.0
      0.515064
      0.355504
      0.538392
      0.136692
      0.160634
      0.179352
      0.0
      0.179352
      0.304709
      0.444590
      0.584831
      0.275469
      0.136273
      0.232486
      0.726700
      0.784468
      0.534703
      0.769952
      0.0
      0.396907
      0.440482
      0.389549
      0.423470
      0.462821
      0.449771
      0.0
      0.449771
      0.465285
      0.426702
      0.407070
      0.397690
      0.445997
      0.414601
      0.361041
      0.422636
      0.409871
      0.372959
      RRBS_cw154_CutSmart_protein
    
    
      20
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.TATCTC
      0.0
      0.576698
      0.407457
      0.601190
      0.156286
      0.179898
      0.203588
      0.0
      0.203588
      0.341264
      0.581638
      0.672314
      0.322060
      0.151705
      0.253217
      0.870145
      0.827566
      0.609707
      0.808661
      0.0
      0.363719
      0.416227
      0.355604
      0.418422
      0.454966
      0.438377
      0.0
      0.438377
      0.442940
      0.321610
      0.394777
      0.380926
      0.444623
      0.400264
      0.253117
      0.374934
      0.378514
      0.347429
      RRBS_cw154_CutSmart_protein
    
    
      21
      RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.TCTCTG
      0.0
      0.565269
      0.398589
      0.589572
      0.157359
      0.178807
      0.211161
      0.0
      0.211161
      0.342742
      0.563872
      0.681485
      0.312209
      0.155151
      0.256075
      0.863981
      0.828704
      0.602805
      0.808628
      0.0
      0.368633
      0.420777
      0.360477
      0.423342
      0.463158
      0.464180
      0.0
      0.464180
      0.449781
      0.310764
      0.373593
      0.395798
      0.454929
      0.396916
      0.177725
      0.372295
      0.384154
      0.345767
      RRBS_cw154_CutSmart_protein
    
    
      22
      RRBS_cw154_Tris_protease_CTCTCTAC.ACAACC
      0.0
      0.534341
      0.373414
      0.559693
      0.140429
      0.159554
      0.178100
      0.0
      0.178100
      0.309936
      0.497813
      0.645147
      0.292520
      0.143238
      0.226691
      0.731040
      0.808980
      0.580810
      0.795186
      0.0
      0.388448
      0.444272
      0.377688
      0.433265
      0.469909
      0.469338
      0.0
      0.469338
      0.451973
      0.651118
      0.429110
      0.404743
      0.471306
      0.398084
      0.377739
      0.394894
      0.395843
      0.368690
      RRBS_cw154_Tris_protease_CT
    
    
      23
      RRBS_cw154_Tris_protease_CTCTCTAC.ACCGCG
      0.0
      0.460252
      0.301662
      0.485655
      0.123422
      0.144838
      0.161997
      0.0
      0.161997
      0.258069
      0.137171
      0.607551
      0.216179
      0.125607
      0.192525
      0.893236
      0.784792
      0.496794
      0.751479
      0.0
      0.393472
      0.439482
      0.385331
      0.422044
      0.459844
      0.438432
      0.0
      0.438432
      0.456989
      0.173419
      0.457588
      0.402154
      0.453262
      0.412374
      0.324368
      0.422718
      0.423725
      0.343020
      RRBS_cw154_Tris_protease_CT
    
    
      24
      RRBS_cw154_Tris_protease_CTCTCTAC.ACGTGG
      0.0
      0.458037
      0.323757
      0.482683
      0.127488
      0.161868
      0.176395
      0.0
      0.176395
      0.285677
      0.407810
      0.584367
      0.216456
      0.126353
      0.201637
      0.975253
      0.791770
      0.517245
      0.752050
      0.0
      0.410130
      0.440868
      0.407166
      0.426673
      0.464655
      0.448130
      0.0
      0.448130
      0.451854
      0.296589
      0.413079
      0.408591
      0.454207
      0.418433
      0.066367
      0.399408
      0.404818
      0.339397
      RRBS_cw154_Tris_protease_CT
    
    
      25
      RRBS_cw154_Tris_protease_CTCTCTAC.ACTCAC
      0.0
      0.590028
      0.422366
      0.612746
      0.168838
      0.192126
      0.204903
      0.0
      0.204903
      0.371221
      0.733536
      0.676370
      0.340330
      0.165456
      0.282602
      0.831377
      0.816232
      0.594412
      0.805338
      0.0
      0.381890
      0.444354
      0.372424
      0.453939
      0.496793
      0.476430
      0.0
      0.476430
      0.467415
      0.134052
      0.405989
      0.397287
      0.473730
      0.425922
      0.237761
      0.393858
      0.396729
      0.348192
      RRBS_cw154_Tris_protease_CT
    
    
      26
      RRBS_cw154_Tris_protease_CTCTCTAC.AGGATG
      0.0
      0.526552
      0.369634
      0.553452
      0.143346
      0.165112
      0.189923
      0.0
      0.189923
      0.319121
      0.419560
      0.650610
      0.281031
      0.137878
      0.234273
      0.826387
      0.793863
      0.560189
      0.785121
      0.0
      0.389957
      0.447900
      0.378239
      0.447429
      0.480496
      0.498393
      0.0
      0.498393
      0.459329
      0.192210
      0.399631
      0.408654
      0.479657
      0.409307
      0.294912
      0.419935
      0.403721
      0.382693
      RRBS_cw154_Tris_protease_CT
    
    
      27
      RRBS_cw154_Tris_protease_CTCTCTAC.ATAGCG
      0.0
      0.514725
      0.364374
      0.536571
      0.138552
      0.163622
      0.209144
      0.0
      0.209144
      0.301816
      0.432663
      0.641328
      0.275702
      0.138910
      0.225859
      0.926267
      0.798583
      0.542398
      0.777647
      0.0
      0.387464
      0.435454
      0.380125
      0.440076
      0.477478
      0.453723
      0.0
      0.453723
      0.448844
      0.455532
      0.378974
      0.401406
      0.462439
      0.404434
      0.175444
      0.404892
      0.414161
      0.349822
      RRBS_cw154_Tris_protease_CT
    
    
      28
      RRBS_cw154_Tris_protease_CTCTCTAC.ATCGAC
      0.0
      0.558080
      0.398185
      0.580534
      0.151438
      0.175596
      0.197664
      0.0
      0.197664
      0.334314
      0.433680
      0.703718
      0.302549
      0.152055
      0.248275
      0.877315
      0.819819
      0.581308
      0.796077
      0.0
      0.380517
      0.431675
      0.373339
      0.438100
      0.476924
      0.467834
      0.0
      0.467834
      0.464795
      0.732005
      0.401747
      0.402183
      0.468532
      0.413423
      0.445849
      0.379814
      0.380670
      0.343064
      RRBS_cw154_Tris_protease_CT
    
    
      29
      RRBS_cw154_Tris_protease_CTCTCTAC.CAAGAG
      0.0
      0.486270
      0.370296
      0.502550
      0.152896
      0.168602
      0.205128
      0.0
      0.205128
      0.170190
      0.235294
      0.743697
      0.231379
      0.191316
      0.100649
      0.500000
      0.848130
      0.564462
      0.827768
      0.0
      0.427703
      0.430160
      0.436737
      0.494695
      0.470844
      0.458974
      0.0
      0.458974
      0.465425
      1.000000
      0.340336
      0.543755
      0.458727
      0.457792
      0.000000
      0.335998
      0.348029
      0.298770
      RRBS_cw154_Tris_protease_CT
    
    
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
    
    
      36
      RRBS_cw154_Tris_protease_CTCTCTAC.GCATTC
      0.0
      0.550686
      0.397458
      0.573475
      0.155206
      0.175344
      0.197986
      0.0
      0.197986
      0.317136
      0.483328
      0.689705
      0.302586
      0.153650
      0.237950
      0.865758
      0.812120
      0.583075
      0.787242
      0.0
      0.383840
      0.440115
      0.373946
      0.430963
      0.471428
      0.460249
      0.0
      0.460249
      0.444606
      0.497993
      0.406583
      0.406167
      0.463870
      0.403142
      0.234360
      0.388152
      0.397824
      0.364322
      RRBS_cw154_Tris_protease_CT
    
    
      37
      RRBS_cw154_Tris_protease_CTCTCTAC.GCTGCC
      0.0
      0.549865
      0.375639
      0.572812
      0.150089
      0.162113
      0.164505
      0.0
      0.164505
      0.324149
      0.608583
      0.611432
      0.317604
      0.143925
      0.240400
      0.757844
      0.797200
      0.527989
      0.792693
      0.0
      0.383353
      0.438283
      0.376650
      0.435875
      0.472296
      0.471156
      0.0
      0.471156
      0.443709
      0.592978
      0.387363
      0.416812
      0.445048
      0.423542
      0.478172
      0.389699
      0.403168
      0.358137
      RRBS_cw154_Tris_protease_CT
    
    
      38
      RRBS_cw154_Tris_protease_CTCTCTAC.GGCATC
      0.0
      0.534038
      0.370099
      0.556779
      0.145719
      0.162697
      0.180510
      0.0
      0.180510
      0.319885
      0.502717
      0.643891
      0.294115
      0.142610
      0.227868
      0.782086
      0.793476
      0.560685
      0.779066
      0.0
      0.393307
      0.441777
      0.386214
      0.433309
      0.468830
      0.459156
      0.0
      0.459156
      0.464283
      0.369318
      0.423972
      0.391096
      0.448848
      0.413452
      0.402209
      0.419728
      0.410595
      0.385529
      RRBS_cw154_Tris_protease_CT
    
    
      39
      RRBS_cw154_Tris_protease_CTCTCTAC.GTGAGG
      0.0
      0.489653
      0.326848
      0.515329
      0.130821
      0.151956
      0.181042
      0.0
      0.181042
      0.287429
      0.652036
      0.607564
      0.253067
      0.128629
      0.208924
      0.832283
      0.789822
      0.519845
      0.771301
      0.0
      0.393518
      0.435982
      0.385103
      0.421115
      0.461429
      0.432756
      0.0
      0.432756
      0.444819
      0.511312
      0.470527
      0.406976
      0.454380
      0.377418
      0.532563
      0.409291
      0.411337
      0.363646
      RRBS_cw154_Tris_protease_CT
    
    
      40
      RRBS_cw154_Tris_protease_CTCTCTAC.GTTGAG
      0.0
      0.531990
      0.370032
      0.557751
      0.135521
      0.158191
      0.182368
      0.0
      0.182368
      0.308875
      0.524319
      0.620437
      0.279451
      0.135809
      0.245574
      0.858791
      0.796981
      0.548003
      0.795593
      0.0
      0.378032
      0.429048
      0.366821
      0.420896
      0.457147
      0.420198
      0.0
      0.420198
      0.441564
      0.596819
      0.350647
      0.385625
      0.446510
      0.377840
      0.322593
      0.416306
      0.394795
      0.360156
      RRBS_cw154_Tris_protease_CT
    
    
      41
      RRBS_cw154_Tris_protease_CTCTCTAC.TAGCGG
      0.0
      0.471778
      0.313727
      0.499631
      0.125400
      0.152194
      0.185181
      0.0
      0.185181
      0.275724
      0.331111
      0.528724
      0.243965
      0.131895
      0.194354
      0.889034
      0.792664
      0.523283
      0.743746
      0.0
      0.400202
      0.440841
      0.390273
      0.438782
      0.479660
      0.487100
      0.0
      0.487100
      0.453398
      0.542222
      0.474395
      0.402119
      0.453015
      0.411555
      0.259791
      0.413971
      0.416831
      0.362602
      RRBS_cw154_Tris_protease_CT
    
    
      42
      RRBS_cw154_Tris_protease_CTCTCTAC.TATCTC
      0.0
      0.516220
      0.350940
      0.542691
      0.144981
      0.164118
      0.185249
      0.0
      0.185249
      0.308461
      0.439266
      0.625922
      0.269605
      0.140071
      0.225836
      0.873896
      0.797049
      0.564834
      0.796188
      0.0
      0.392915
      0.435968
      0.384976
      0.433091
      0.471331
      0.468878
      0.0
      0.468878
      0.454272
      0.560982
      0.409778
      0.400449
      0.448436
      0.404954
      0.250000
      0.417221
      0.404421
      0.371054
      RRBS_cw154_Tris_protease_CT
    
    
      43
      RRBS_cw154_Tris_protease_CTCTCTAC.TCTCTG
      0.0
      0.553577
      0.386507
      0.579787
      0.155410
      0.178985
      0.208762
      0.0
      0.208762
      0.336380
      0.501952
      0.654150
      0.298292
      0.152577
      0.246424
      0.827148
      0.817611
      0.585299
      0.788970
      0.0
      0.377694
      0.434611
      0.366589
      0.438043
      0.475137
      0.472028
      0.0
      0.472028
      0.459645
      0.571333
      0.377541
      0.397031
      0.456302
      0.423987
      0.213718
      0.388219
      0.394885
      0.358565
      RRBS_cw154_Tris_protease_CT
    
    
      44
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.ACAACC
      0.0
      0.576284
      0.406097
      0.601754
      0.161465
      0.185395
      0.207583
      0.0
      0.207583
      0.357942
      0.547005
      0.670954
      0.324295
      0.157820
      0.268130
      0.846800
      0.817763
      0.599877
      0.789617
      0.0
      0.385672
      0.442893
      0.376316
      0.443877
      0.485673
      0.476193
      0.0
      0.476193
      0.477462
      0.557266
      0.414924
      0.405707
      0.472460
      0.436088
      0.193601
      0.390099
      0.402147
      0.356893
      RRBS_cw154_Tris_protease_GR
    
    
      45
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.ACCGCG
      0.0
      0.511334
      0.343362
      0.525529
      0.146702
      0.155815
      0.161441
      0.0
      0.161441
      0.300844
      0.255682
      0.604491
      0.270828
      0.137620
      0.232425
      0.460251
      0.763500
      0.494908
      0.734817
      0.0
      0.421948
      0.474217
      0.419047
      0.445339
      0.484756
      0.396339
      0.0
      0.396339
      0.472072
      0.625000
      0.475384
      0.430449
      0.478865
      0.442140
      0.246862
      0.427111
      0.408966
      0.424868
      RRBS_cw154_Tris_protease_GR
    
    
      46
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.ACGTGG
      0.0
      0.512682
      0.345234
      0.536809
      0.137729
      0.160869
      0.176882
      0.0
      0.176882
      0.311430
      0.473591
      0.616956
      0.277755
      0.130273
      0.230467
      0.931588
      0.793475
      0.532694
      0.771031
      0.0
      0.398524
      0.452411
      0.391642
      0.448729
      0.485078
      0.475244
      0.0
      0.475244
      0.463947
      0.347774
      0.436047
      0.417028
      0.471349
      0.425034
      0.192148
      0.416041
      0.417826
      0.365604
      RRBS_cw154_Tris_protease_GR
    
    
      47
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.ACTCAC
      0.0
      0.573171
      0.401849
      0.597199
      0.151773
      0.171875
      0.194561
      0.0
      0.194561
      0.345406
      0.517198
      0.670404
      0.319500
      0.153398
      0.263630
      0.815552
      0.823303
      0.608822
      0.800335
      0.0
      0.378345
      0.434331
      0.370594
      0.440354
      0.477316
      0.461536
      0.0
      0.461536
      0.463942
      0.533343
      0.377821
      0.398082
      0.465740
      0.432103
      0.403309
      0.383423
      0.391929
      0.353436
      RRBS_cw154_Tris_protease_GR
    
    
      48
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.AGGATG
      0.0
      0.564190
      0.400639
      0.587070
      0.156148
      0.178286
      0.200963
      0.0
      0.200963
      0.341886
      0.720597
      0.682988
      0.310596
      0.151629
      0.253827
      0.866745
      0.815414
      0.594260
      0.803257
      0.0
      0.379929
      0.434078
      0.371444
      0.444880
      0.483348
      0.468416
      0.0
      0.468416
      0.458227
      0.361589
      0.389223
      0.405786
      0.467325
      0.408632
      0.225639
      0.388187
      0.390956
      0.356615
      RRBS_cw154_Tris_protease_GR
    
    
      49
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.ATAGCG
      0.0
      0.511650
      0.347418
      0.536770
      0.130230
      0.152742
      0.171285
      0.0
      0.171285
      0.301554
      0.600641
      0.620994
      0.268694
      0.129413
      0.230489
      0.721732
      0.801653
      0.536829
      0.779564
      0.0
      0.389526
      0.437767
      0.377810
      0.426748
      0.469372
      0.442436
      0.0
      0.442436
      0.460019
      0.354316
      0.390483
      0.394218
      0.452053
      0.397870
      0.406152
      0.393092
      0.402037
      0.364014
      RRBS_cw154_Tris_protease_GR
    
    
      50
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.ATCGAC
      0.0
      0.581265
      0.413731
      0.604593
      0.159955
      0.182839
      0.200410
      0.0
      0.200410
      0.348518
      0.473692
      0.685157
      0.329431
      0.157349
      0.261800
      0.883827
      0.827906
      0.608313
      0.808906
      0.0
      0.378523
      0.439229
      0.367856
      0.442772
      0.484959
      0.491116
      0.0
      0.491116
      0.471417
      0.430501
      0.409146
      0.406994
      0.473154
      0.427580
      0.355927
      0.376216
      0.398450
      0.348651
      RRBS_cw154_Tris_protease_GR
    
    
      51
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.CAAGAG
      0.0
      0.000000
      0.372152
      0.546730
      0.184593
      0.188679
      0.283105
      0.0
      0.283105
      0.368590
      0.000000
      0.694737
      0.249365
      0.219697
      0.267257
      NaN
      0.805740
      0.603448
      0.860000
      0.0
      0.369933
      0.427426
      0.365895
      0.447646
      0.463819
      0.458143
      0.0
      0.458143
      0.495726
      0.000000
      0.436842
      0.409264
      0.415909
      0.522124
      0.000000
      0.374869
      0.358012
      0.230000
      RRBS_cw154_Tris_protease_GR
    
    
      52
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.CATGAC
      0.0
      0.587509
      0.432016
      0.608034
      0.165995
      0.187324
      0.214616
      0.0
      0.214616
      0.367932
      0.518964
      0.674795
      0.330463
      0.168557
      0.271944
      0.902915
      0.821682
      0.598753
      0.808898
      0.0
      0.381658
      0.436510
      0.374043
      0.451143
      0.490825
      0.466760
      0.0
      0.466760
      0.462817
      0.547771
      0.413982
      0.411164
      0.476445
      0.416048
      0.233673
      0.385518
      0.398958
      0.344039
      RRBS_cw154_Tris_protease_GR
    
    
      53
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.CCTTCG
      0.0
      0.516150
      0.346647
      0.540346
      0.143693
      0.154591
      0.175251
      0.0
      0.175251
      0.310324
      0.413022
      0.614101
      0.274294
      0.137531
      0.228403
      0.769873
      0.783656
      0.524627
      0.766010
      0.0
      0.392435
      0.446851
      0.385694
      0.434338
      0.475932
      0.485631
      0.0
      0.485631
      0.436179
      0.792247
      0.403187
      0.403722
      0.464367
      0.398929
      0.258439
      0.416008
      0.411363
      0.378304
      RRBS_cw154_Tris_protease_GR
    
    
      54
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.CGGTAG
      0.0
      0.534594
      0.369322
      0.558910
      0.146821
      0.161236
      0.192204
      0.0
      0.192204
      0.310096
      0.545982
      0.604021
      0.284603
      0.144641
      0.235544
      0.837650
      0.794706
      0.546525
      0.773418
      0.0
      0.386344
      0.440891
      0.378346
      0.439248
      0.487651
      0.475052
      0.0
      0.475052
      0.463789
      0.426339
      0.398519
      0.407179
      0.461797
      0.431631
      0.290587
      0.397254
      0.397529
      0.366067
      RRBS_cw154_Tris_protease_GR
    
    
      55
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.CTATTG
      0.0
      0.506774
      0.372387
      0.528822
      0.145138
      0.174562
      0.185376
      0.0
      0.185376
      0.313840
      0.351714
      0.634783
      0.260631
      0.147495
      0.225961
      0.888504
      0.800684
      0.565772
      0.791344
      0.0
      0.397668
      0.443187
      0.389245
      0.434167
      0.479863
      0.461500
      0.0
      0.461500
      0.466725
      0.299837
      0.448787
      0.405493
      0.460125
      0.402327
      0.284124
      0.403780
      0.397252
      0.388561
      RRBS_cw154_Tris_protease_GR
    
    
      56
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.CTCAGC
      0.0
      0.585109
      0.420451
      0.608710
      0.164237
      0.177026
      0.200596
      0.0
      0.200596
      0.354298
      0.402174
      0.652141
      0.332674
      0.155343
      0.274508
      0.897694
      0.802184
      0.584740
      0.811600
      0.0
      0.380717
      0.430851
      0.372447
      0.446459
      0.484725
      0.452090
      0.0
      0.452090
      0.470944
      0.403339
      0.398307
      0.408462
      0.454746
      0.447672
      0.241869
      0.407099
      0.410584
      0.357457
      RRBS_cw154_Tris_protease_GR
    
    
      57
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.GACACG
      0.0
      0.515384
      0.348097
      0.540523
      0.136907
      0.150941
      0.169903
      0.0
      0.169903
      0.302160
      0.415330
      0.628959
      0.278453
      0.132860
      0.220073
      0.945615
      0.790033
      0.517115
      0.755147
      0.0
      0.397503
      0.455544
      0.389747
      0.437309
      0.480080
      0.467647
      0.0
      0.467647
      0.456722
      0.269456
      0.408003
      0.418366
      0.481040
      0.413696
      0.220401
      0.395705
      0.414493
      0.385641
      RRBS_cw154_Tris_protease_GR
    
    
      58
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.GCATTC
      0.0
      0.608538
      0.428746
      0.629168
      0.173777
      0.186020
      0.225286
      0.0
      0.225286
      0.365004
      0.607946
      0.682409
      0.362460
      0.161610
      0.266919
      0.943119
      0.820956
      0.601619
      0.811971
      0.0
      0.373311
      0.429765
      0.366590
      0.449237
      0.490146
      0.514217
      0.0
      0.514217
      0.463287
      0.525091
      0.398041
      0.400434
      0.468651
      0.427292
      0.251376
      0.386496
      0.409402
      0.348546
      RRBS_cw154_Tris_protease_GR
    
    
      59
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.GCTGCC
      0.0
      0.576122
      0.404285
      0.598434
      0.162122
      0.181122
      0.220391
      0.0
      0.220391
      0.353660
      0.488789
      0.695825
      0.342339
      0.158025
      0.267716
      0.868908
      0.802257
      0.574030
      0.802627
      0.0
      0.392724
      0.459133
      0.382072
      0.448174
      0.497532
      0.473646
      0.0
      0.473646
      0.442382
      0.715994
      0.419597
      0.426912
      0.490002
      0.393181
      0.174790
      0.404133
      0.416121
      0.340402
      RRBS_cw154_Tris_protease_GR
    
    
      60
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.GGCATC
      0.0
      0.567852
      0.405896
      0.589092
      0.159208
      0.173028
      0.194514
      0.0
      0.194514
      0.339230
      0.400992
      0.625731
      0.327633
      0.153576
      0.241934
      0.824254
      0.797284
      0.567597
      0.778227
      0.0
      0.393760
      0.455299
      0.386012
      0.451880
      0.500343
      0.508443
      0.0
      0.508443
      0.480389
      0.404090
      0.447343
      0.421022
      0.480479
      0.440682
      0.414732
      0.411504
      0.411222
      0.373854
      RRBS_cw154_Tris_protease_GR
    
    
      61
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.GTGAGG
      0.0
      0.540579
      0.378239
      0.563490
      0.148783
      0.168545
      0.180514
      0.0
      0.180514
      0.310731
      0.521963
      0.667501
      0.303415
      0.143335
      0.227983
      0.820113
      0.793085
      0.542785
      0.767958
      0.0
      0.401265
      0.458648
      0.394131
      0.454753
      0.489479
      0.463048
      0.0
      0.463048
      0.465206
      0.518934
      0.391409
      0.415603
      0.493483
      0.414381
      0.373337
      0.403627
      0.402933
      0.389869
      RRBS_cw154_Tris_protease_GR
    
    
      62
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.GTTGAG
      0.0
      0.590227
      0.420827
      0.615305
      0.167125
      0.186078
      0.203812
      0.0
      0.203812
      0.365675
      0.464368
      0.654491
      0.343965
      0.176519
      0.283145
      0.911492
      0.808049
      0.596742
      0.792297
      0.0
      0.384102
      0.433679
      0.374276
      0.441195
      0.482594
      0.457740
      0.0
      0.457740
      0.471821
      0.675575
      0.414101
      0.400324
      0.461227
      0.430853
      0.246331
      0.398943
      0.401963
      0.361181
      RRBS_cw154_Tris_protease_GR
    
    
      63
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.TAGCGG
      0.0
      0.551284
      0.385638
      0.574912
      0.152819
      0.166841
      0.182777
      0.0
      0.182777
      0.317631
      0.606152
      0.628592
      0.322355
      0.152436
      0.238888
      0.879544
      0.784437
      0.541362
      0.761603
      0.0
      0.389318
      0.439817
      0.380264
      0.431510
      0.483114
      0.470635
      0.0
      0.470635
      0.455824
      0.668417
      0.378515
      0.399306
      0.451436
      0.432468
      0.149803
      0.405760
      0.397798
      0.373977
      RRBS_cw154_Tris_protease_GR
    
    
      64
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.TATCTC
      0.0
      0.587895
      0.412116
      0.613305
      0.165356
      0.185364
      0.209044
      0.0
      0.209044
      0.353929
      0.580729
      0.665446
      0.343067
      0.159167
      0.268219
      0.780298
      0.816863
      0.589350
      0.788591
      0.0
      0.376174
      0.435518
      0.367302
      0.448862
      0.487347
      0.475819
      0.0
      0.475819
      0.458763
      0.523438
      0.370440
      0.413176
      0.476628
      0.412619
      0.439182
      0.387418
      0.387567
      0.355424
      RRBS_cw154_Tris_protease_GR
    
    
      65
      RRBS_cw154_Tris_protease_GR_CAGAGAGG.TCTCTG
      0.0
      0.563683
      0.396403
      0.586718
      0.154660
      0.175256
      0.209778
      0.0
      0.209778
      0.336147
      0.540323
      0.668507
      0.315953
      0.154404
      0.243405
      0.791259
      0.803866
      0.580085
      0.803588
      0.0
      0.383811
      0.442727
      0.373669
      0.431037
      0.478234
      0.464356
      0.0
      0.464356
      0.461964
      0.353719
      0.412310
      0.396713
      0.462184
      0.405112
      0.475546
      0.405538
      0.402137
      0.342846
      RRBS_cw154_Tris_protease_GR
    
  

66 rows × 40 columns







    



In [27] used 0.074 MiB RAM in 0.246s, peaked 0.000 MiB above current, total RAM usage 104.539 MiB



In [28]:

    
files = [trito, normal, pcell, mcell, cw154, cd19cell]









    



In [28] used 0.059 MiB RAM in 0.002s, peaked 0.016 MiB above current, total RAM usage 104.598 MiB



In [29]:

    
total_region_files = pd.concat([trito, normal, pcell, mcell, cw154, cd19cell])









    



In [29] used 0.188 MiB RAM in 0.011s, peaked 0.000 MiB above current, total RAM usage 104.785 MiB



In [30]:

    
total_region_files.shape









    Out[30]:





(513, 40)






    



In [30] used 0.016 MiB RAM in 0.003s, peaked 0.000 MiB above current, total RAM usage 104.801 MiB



In [31]:

    
total_region_files = total_region_files[["filename", "methylation_tssDistance","methylation_genesDistance","methylation_exonsDistance",
                 "methylation_intronsDistance", "methylation_promoterDistance","methylation_cgiDistance",
                 "methylation_ctcfDistance","methylation_ctcfUpDistance","methylation_ctcfDownDistance",
                 "methylation_geneDistalRegulatoryModulesDistance","methylation_vistaEnhancersDistance",
                 "methylation_3PrimeUTRDistance","methylation_5PrimeUTRDistance",
                 "methylation_firstExonDistance","methylation_geneDistalRegulatoryModulesK562Distance",
                 "methylation_hypoInHues64Distance","methylation_intergenic",
                 "methylation_shore","methylation_shelf","PDR_tssDistance",
                 "PDR_genesDistance","PDR_exonsDistance","PDR_intronsDistance", "PDR_promoterDistance",
                 "PDR_cgiDistance","PDR_ctcfDistance","PDR_ctcfUpDistance","PDR_ctcfDownDistance",
                 "PDR_geneDistalRegulatoryModulesDistance","PDR_vistaEnhancersDistance","PDR_3PrimeUTRDistance",
                 "PDR_5PrimeUTRDistance","PDR_firstExonDistance","PDR_geneDistalRegulatoryModulesK562Distance",
                 "PDR_hypoInHues64Distance","PDR_intergenic","PDR_shore","PDR_shelf"]]









    



In [31] used 0.074 MiB RAM in 0.012s, peaked 0.000 MiB above current, total RAM usage 104.875 MiB



In [35]:

    
total_region_files = total_region_files.reset_index(drop=True)









    



In [35] used 0.000 MiB RAM in 0.002s, peaked 0.000 MiB above current, total RAM usage 105.898 MiB



In [37]:

    
total_region_files[:40]









    Out[37]:






  
    
      
      filename
      methylation_tssDistance
      methylation_genesDistance
      methylation_exonsDistance
      methylation_intronsDistance
      methylation_promoterDistance
      methylation_cgiDistance
      methylation_ctcfDistance
      methylation_ctcfUpDistance
      methylation_ctcfDownDistance
      methylation_geneDistalRegulatoryModulesDistance
      methylation_vistaEnhancersDistance
      methylation_3PrimeUTRDistance
      methylation_5PrimeUTRDistance
      methylation_firstExonDistance
      methylation_geneDistalRegulatoryModulesK562Distance
      methylation_hypoInHues64Distance
      methylation_intergenic
      methylation_shore
      methylation_shelf
      PDR_tssDistance
      PDR_genesDistance
      PDR_exonsDistance
      PDR_intronsDistance
      PDR_promoterDistance
      PDR_cgiDistance
      PDR_ctcfDistance
      PDR_ctcfUpDistance
      PDR_ctcfDownDistance
      PDR_geneDistalRegulatoryModulesDistance
      PDR_vistaEnhancersDistance
      PDR_3PrimeUTRDistance
      PDR_5PrimeUTRDistance
      PDR_firstExonDistance
      PDR_geneDistalRegulatoryModulesK562Distance
      PDR_hypoInHues64Distance
      PDR_intergenic
      PDR_shore
      PDR_shelf
    
  
  
    
      0
      RRBS_trito_pool_1_TAAGGCGA.ACAACC
      0.0
      0.570721
      0.404589
      0.594704
      0.146371
      0.169386
      0.199815
      0.0
      0.199815
      0.342986
      0.444522
      0.680480
      0.305206
      0.145730
      0.254209
      0.877142
      0.820339
      0.607671
      0.803716
      0.0
      0.343014
      0.371890
      0.339596
      0.347748
      0.388709
      0.385297
      0.0
      0.385297
      0.401254
      0.509555
      0.386285
      0.324236
      0.367271
      0.354046
      0.240359
      0.386809
      0.377907
      0.359143
    
    
      1
      RRBS_trito_pool_1_TAAGGCGA.ACGTGG
      0.0
      0.545781
      0.383371
      0.568638
      0.141545
      0.161519
      0.191404
      0.0
      0.191404
      0.326140
      0.589834
      0.670559
      0.290196
      0.140779
      0.240221
      0.809942
      0.816166
      0.573089
      0.795932
      0.0
      0.348110
      0.381251
      0.341950
      0.349891
      0.398898
      0.415058
      0.0
      0.415058
      0.408417
      0.548192
      0.382172
      0.332749
      0.373615
      0.359217
      0.364148
      0.391925
      0.386808
      0.354120
    
    
      2
      RRBS_trito_pool_1_TAAGGCGA.ACTCAC
      0.0
      0.564547
      0.401760
      0.588136
      0.148529
      0.174413
      0.209041
      0.0
      0.209041
      0.346473
      0.553062
      0.696068
      0.296809
      0.148360
      0.255392
      0.795883
      0.832812
      0.609544
      0.812564
      0.0
      0.338412
      0.371890
      0.332321
      0.351391
      0.393829
      0.392313
      0.0
      0.392313
      0.412311
      0.471703
      0.378630
      0.327488
      0.370494
      0.338321
      0.334783
      0.378580
      0.378799
      0.353949
    
    
      3
      RRBS_trito_pool_1_TAAGGCGA.AGGATG
      0.0
      0.567309
      0.399934
      0.592890
      0.143897
      0.168936
      0.200661
      0.0
      0.200661
      0.342257
      0.665920
      0.661426
      0.308680
      0.141673
      0.242236
      0.787966
      0.824659
      0.602995
      0.799836
      0.0
      0.342724
      0.374419
      0.337654
      0.346109
      0.389718
      0.399153
      0.0
      0.399153
      0.405627
      0.359189
      0.391002
      0.324431
      0.360431
      0.343730
      0.304035
      0.380413
      0.373345
      0.347372
    
    
      4
      RRBS_trito_pool_1_TAAGGCGA.ATAGCG
      0.0
      0.529224
      0.367743
      0.555131
      0.136090
      0.156827
      0.175426
      0.0
      0.175426
      0.307402
      0.479145
      0.644411
      0.273473
      0.134137
      0.220729
      0.815944
      0.808981
      0.575050
      0.788587
      0.0
      0.349254
      0.376307
      0.342617
      0.343348
      0.388623
      0.403861
      0.0
      0.403861
      0.390288
      0.471324
      0.392438
      0.332882
      0.358450
      0.319824
      0.401641
      0.398275
      0.373236
      0.363320
    
    
      5
      RRBS_trito_pool_1_TAAGGCGA.ATCGAC
      0.0
      0.566031
      0.393281
      0.591518
      0.145246
      0.162973
      0.199969
      0.0
      0.199969
      0.333682
      0.490492
      0.667285
      0.304792
      0.138075
      0.248255
      0.853356
      0.817065
      0.601387
      0.800064
      0.0
      0.343104
      0.371148
      0.338015
      0.350522
      0.390895
      0.405243
      0.0
      0.405243
      0.397617
      0.586487
      0.367571
      0.325332
      0.362838
      0.333114
      0.328968
      0.389536
      0.375595
      0.350909
    
    
      6
      RRBS_trito_pool_1_TAAGGCGA.CAAGAG
      0.0
      0.566742
      0.402345
      0.590378
      0.152305
      0.173906
      0.195518
      0.0
      0.195518
      0.346568
      0.533040
      0.656980
      0.304390
      0.149536
      0.253048
      0.805577
      0.816897
      0.603907
      0.803092
      0.0
      0.350942
      0.386671
      0.344248
      0.364405
      0.406190
      0.400039
      0.0
      0.400039
      0.421197
      0.545560
      0.392756
      0.338890
      0.381441
      0.356823
      0.307240
      0.394851
      0.384458
      0.357089
    
    
      7
      RRBS_trito_pool_1_TAAGGCGA.CATGAC
      0.0
      0.566995
      0.407400
      0.589923
      0.148278
      0.174522
      0.209616
      0.0
      0.209616
      0.337079
      0.476748
      0.678752
      0.300825
      0.146025
      0.243253
      0.863080
      0.824824
      0.602455
      0.801551
      0.0
      0.345160
      0.379410
      0.338777
      0.353197
      0.399885
      0.399392
      0.0
      0.399392
      0.398004
      0.482805
      0.394881
      0.334431
      0.375372
      0.332435
      0.345932
      0.381070
      0.373821
      0.350244
    
    
      8
      RRBS_trito_pool_1_TAAGGCGA.CCTTCG
      0.0
      0.544137
      0.377628
      0.568732
      0.136603
      0.163191
      0.191971
      0.0
      0.191971
      0.312724
      0.428419
      0.644483
      0.284865
      0.139631
      0.229110
      0.812046
      0.810739
      0.567608
      0.784795
      0.0
      0.345857
      0.376641
      0.339524
      0.349919
      0.393570
      0.413810
      0.0
      0.413810
      0.407238
      0.334977
      0.388436
      0.324229
      0.367053
      0.354882
      0.307155
      0.397849
      0.390108
      0.346731
    
    
      9
      RRBS_trito_pool_1_TAAGGCGA.CGGTAG
      0.0
      0.540051
      0.369671
      0.565375
      0.139633
      0.163692
      0.198751
      0.0
      0.198751
      0.312778
      0.531099
      0.642033
      0.284431
      0.138257
      0.223869
      0.851775
      0.809572
      0.567265
      0.792353
      0.0
      0.354063
      0.391736
      0.346245
      0.357297
      0.403435
      0.414073
      0.0
      0.414073
      0.409215
      0.462336
      0.404820
      0.330088
      0.374945
      0.334288
      0.296450
      0.398979
      0.390262
      0.360787
    
    
      10
      RRBS_trito_pool_1_TAAGGCGA.CTATTG
      0.0
      0.579098
      0.413628
      0.602551
      0.149996
      0.174348
      0.206507
      0.0
      0.206507
      0.340917
      0.479200
      0.681367
      0.314310
      0.147705
      0.250151
      0.842639
      0.825690
      0.610104
      0.808571
      0.0
      0.334826
      0.363741
      0.331545
      0.340101
      0.389592
      0.384261
      0.0
      0.384261
      0.399187
      0.295595
      0.361252
      0.316965
      0.356730
      0.331182
      0.275036
      0.384923
      0.370680
      0.338867
    
    
      11
      RRBS_trito_pool_1_TAAGGCGA.GACACG
      0.0
      0.549829
      0.379579
      0.572968
      0.142349
      0.163858
      0.194206
      0.0
      0.194206
      0.320273
      0.511181
      0.628813
      0.297707
      0.137945
      0.231191
      0.913175
      0.808944
      0.575022
      0.795743
      0.0
      0.347308
      0.375613
      0.343617
      0.356474
      0.398687
      0.405318
      0.0
      0.405318
      0.403924
      0.414471
      0.390100
      0.335772
      0.368552
      0.331528
      0.181846
      0.396579
      0.382919
      0.352013
    
    
      12
      RRBS_trito_pool_1_TAAGGCGA.GCATTC
      0.0
      0.577097
      0.411205
      0.599875
      0.149844
      0.176529
      0.209171
      0.0
      0.209171
      0.340387
      0.512575
      0.667962
      0.312442
      0.150562
      0.251066
      0.868216
      0.824084
      0.608142
      0.803492
      0.0
      0.340215
      0.377824
      0.332149
      0.354279
      0.402852
      0.387265
      0.0
      0.387265
      0.416357
      0.373845
      0.376155
      0.331282
      0.370933
      0.363017
      0.378312
      0.390375
      0.366399
      0.364220
    
    
      13
      RRBS_trito_pool_1_TAAGGCGA.GCTGCC
      0.0
      0.544259
      0.384439
      0.564795
      0.139736
      0.162409
      0.176248
      0.0
      0.176248
      0.318136
      0.574486
      0.634002
      0.289043
      0.139641
      0.223191
      0.856793
      0.800237
      0.554718
      0.776976
      0.0
      0.354565
      0.388414
      0.347581
      0.360744
      0.402607
      0.390989
      0.0
      0.390989
      0.431375
      0.409462
      0.385777
      0.340581
      0.375888
      0.372911
      0.350551
      0.400626
      0.404546
      0.364278
    
    
      14
      RRBS_trito_pool_1_TAAGGCGA.GGCATC
      0.0
      0.555539
      0.392705
      0.579332
      0.145652
      0.164935
      0.184172
      0.0
      0.184172
      0.333482
      0.421168
      0.661779
      0.296269
      0.147555
      0.241141
      0.825601
      0.813275
      0.589382
      0.790102
      0.0
      0.349269
      0.378454
      0.343167
      0.352282
      0.398483
      0.383984
      0.0
      0.383984
      0.394837
      0.570345
      0.396641
      0.337457
      0.375483
      0.341387
      0.228666
      0.393968
      0.384816
      0.358044
    
    
      15
      RRBS_trito_pool_1_TAAGGCGA.GTGAGG
      0.0
      0.530569
      0.367508
      0.554714
      0.134121
      0.155524
      0.173857
      0.0
      0.173857
      0.315881
      0.463581
      0.615143
      0.280369
      0.133060
      0.232378
      0.794342
      0.804363
      0.553666
      0.777878
      0.0
      0.358688
      0.390493
      0.351879
      0.361701
      0.404384
      0.398420
      0.0
      0.398420
      0.422339
      0.427769
      0.417731
      0.341625
      0.380159
      0.367890
      0.326313
      0.400965
      0.391422
      0.373351
    
    
      16
      RRBS_trito_pool_1_TAAGGCGA.GTTGAG
      0.0
      0.557958
      0.396493
      0.580842
      0.143581
      0.165943
      0.198223
      0.0
      0.198223
      0.335718
      0.511515
      0.653486
      0.294972
      0.142042
      0.251258
      0.808442
      0.821536
      0.592957
      0.795827
      0.0
      0.344146
      0.371379
      0.337804
      0.354805
      0.397635
      0.404505
      0.0
      0.404505
      0.420580
      0.415804
      0.359175
      0.330021
      0.365134
      0.366449
      0.413398
      0.375629
      0.381035
      0.346115
    
    
      17
      RRBS_trito_pool_1_TAAGGCGA.TAGCGG
      0.0
      0.540878
      0.368191
      0.564637
      0.133724
      0.153977
      0.166738
      0.0
      0.166738
      0.307876
      0.486900
      0.632573
      0.286827
      0.128397
      0.230826
      0.856077
      0.814219
      0.577274
      0.793247
      0.0
      0.346260
      0.378683
      0.339097
      0.356597
      0.396187
      0.381571
      0.0
      0.381571
      0.400928
      0.570090
      0.362619
      0.339981
      0.379723
      0.344153
      0.377799
      0.385887
      0.384042
      0.349956
    
    
      18
      RRBS_trito_pool_1_TAAGGCGA.TATCTC
      0.0
      0.575676
      0.409355
      0.600599
      0.148591
      0.174386
      0.194566
      0.0
      0.194566
      0.336279
      0.554679
      0.662141
      0.309579
      0.142574
      0.240360
      0.844196
      0.822712
      0.607978
      0.806099
      0.0
      0.341342
      0.367808
      0.337694
      0.339362
      0.386849
      0.380734
      0.0
      0.380734
      0.394130
      0.514109
      0.395076
      0.319727
      0.356904
      0.318327
      0.309309
      0.390633
      0.376339
      0.360353
    
    
      19
      RRBS_trito_pool_1_TAAGGCGA.TCTCTG
      0.0
      0.573932
      0.402771
      0.597337
      0.153348
      0.175088
      0.200765
      0.0
      0.200765
      0.347808
      0.610443
      0.676611
      0.311039
      0.144939
      0.256872
      0.854733
      0.826905
      0.607012
      0.802475
      0.0
      0.342377
      0.370775
      0.337035
      0.356039
      0.402495
      0.412892
      0.0
      0.412892
      0.408307
      0.464521
      0.389068
      0.330017
      0.366829
      0.337809
      0.241373
      0.383198
      0.378137
      0.345602
    
    
      20
      RRBS_trito_pool_1_TAAGGCGA.TGACAG
      0.0
      0.567869
      0.399077
      0.591561
      0.148038
      0.176237
      0.202154
      0.0
      0.202154
      0.343355
      0.522213
      0.665558
      0.303592
      0.146534
      0.252288
      0.796484
      0.830742
      0.598186
      0.806577
      0.0
      0.345410
      0.381678
      0.340699
      0.363333
      0.411799
      0.398106
      0.0
      0.398106
      0.406224
      0.468663
      0.352417
      0.345042
      0.391606
      0.339766
      0.370686
      0.369564
      0.369690
      0.345702
    
    
      21
      RRBS_trito_pool_1_TAAGGCGA.TGCTGC
      0.0
      0.549810
      0.381938
      0.576183
      0.143244
      0.162055
      0.182065
      0.0
      0.182065
      0.322882
      0.522536
      0.636949
      0.297776
      0.142530
      0.244198
      0.808005
      0.807068
      0.566512
      0.789342
      0.0
      0.361772
      0.392851
      0.356422
      0.365182
      0.413081
      0.408349
      0.0
      0.408349
      0.431775
      0.422301
      0.386494
      0.344547
      0.390997
      0.368241
      0.364905
      0.392520
      0.386162
      0.373449
    
    
      22
      RRBS_trito_pool_2_CGTACTAG.ACAACC
      0.0
      0.571434
      0.403317
      0.595518
      0.150534
      0.172412
      0.197820
      0.0
      0.197820
      0.335046
      0.542060
      0.674691
      0.311226
      0.145333
      0.251228
      0.782911
      0.825876
      0.601882
      0.804140
      0.0
      0.356830
      0.396188
      0.349903
      0.388446
      0.425970
      0.423147
      0.0
      0.423147
      0.414028
      0.406933
      0.353024
      0.363997
      0.410352
      0.353075
      0.404312
      0.376888
      0.385532
      0.352623
    
    
      23
      RRBS_trito_pool_2_CGTACTAG.ACGTGG
      0.0
      0.547223
      0.381861
      0.572699
      0.142991
      0.167937
      0.187875
      0.0
      0.187875
      0.322376
      0.494384
      0.655945
      0.290386
      0.138317
      0.228471
      0.824135
      0.809657
      0.575763
      0.782319
      0.0
      0.367896
      0.410155
      0.360025
      0.392362
      0.439690
      0.423503
      0.0
      0.423503
      0.424893
      0.371724
      0.396436
      0.364995
      0.415006
      0.358457
      0.266702
      0.393868
      0.396684
      0.361810
    
    
      24
      RRBS_trito_pool_2_CGTACTAG.ACTCAC
      0.0
      0.574078
      0.410369
      0.599662
      0.154807
      0.180722
      0.204649
      0.0
      0.204649
      0.346719
      0.484916
      0.687740
      0.314513
      0.155080
      0.260803
      0.812211
      0.828639
      0.608617
      0.812883
      0.0
      0.360783
      0.413536
      0.352271
      0.396930
      0.438502
      0.437218
      0.0
      0.437218
      0.434233
      0.243128
      0.391187
      0.371005
      0.424675
      0.381663
      0.401646
      0.380932
      0.388726
      0.364671
    
    
      25
      RRBS_trito_pool_2_CGTACTAG.AGGATG
      0.0
      0.574464
      0.411157
      0.598317
      0.153244
      0.179052
      0.205426
      0.0
      0.205426
      0.347422
      0.549476
      0.674730
      0.318179
      0.150916
      0.255366
      0.825079
      0.819016
      0.600086
      0.803518
      0.0
      0.361346
      0.394711
      0.356405
      0.385541
      0.430138
      0.435397
      0.0
      0.435397
      0.430261
      0.509647
      0.397243
      0.354870
      0.405106
      0.376955
      0.349346
      0.390618
      0.387689
      0.355591
    
    
      26
      RRBS_trito_pool_2_CGTACTAG.ATAGCG
      0.0
      0.530317
      0.372598
      0.555500
      0.139056
      0.162002
      0.188584
      0.0
      0.188584
      0.314593
      0.662600
      0.651363
      0.276445
      0.139170
      0.226507
      0.782103
      0.805115
      0.577048
      0.796431
      0.0
      0.368334
      0.399350
      0.363279
      0.375962
      0.421184
      0.422536
      0.0
      0.422536
      0.423652
      0.422062
      0.390546
      0.352241
      0.394821
      0.362621
      0.349869
      0.400868
      0.397587
      0.375378
    
    
      27
      RRBS_trito_pool_2_CGTACTAG.ATCGAC
      0.0
      0.579706
      0.417754
      0.601652
      0.154766
      0.179131
      0.214474
      0.0
      0.214474
      0.347695
      0.592746
      0.693724
      0.318722
      0.152873
      0.251772
      0.829067
      0.818502
      0.603463
      0.804070
      0.0
      0.365534
      0.410172
      0.359211
      0.392262
      0.438666
      0.432635
      0.0
      0.432635
      0.437134
      0.550723
      0.406531
      0.367066
      0.412751
      0.381165
      0.291126
      0.388891
      0.385826
      0.368804
    
    
      28
      RRBS_trito_pool_2_CGTACTAG.CAAGAG
      0.0
      0.562102
      0.395170
      0.587195
      0.146861
      0.171793
      0.193740
      0.0
      0.193740
      0.336475
      0.643228
      0.644603
      0.303090
      0.145796
      0.249175
      0.867900
      0.811712
      0.594372
      0.798705
      0.0
      0.371383
      0.417443
      0.364244
      0.392824
      0.439427
      0.424017
      0.0
      0.424017
      0.430895
      0.419896
      0.406159
      0.358254
      0.421774
      0.375869
      0.285465
      0.405000
      0.385932
      0.366543
    
    
      29
      RRBS_trito_pool_2_CGTACTAG.CATGAC
      0.0
      0.572795
      0.406324
      0.595511
      0.149580
      0.173139
      0.207084
      0.0
      0.207084
      0.341760
      0.582188
      0.686507
      0.311526
      0.145188
      0.255092
      0.898922
      0.822096
      0.602356
      0.802416
      0.0
      0.363315
      0.403748
      0.356727
      0.385169
      0.426971
      0.428521
      0.0
      0.428521
      0.437559
      0.666602
      0.399967
      0.360502
      0.402785
      0.382317
      0.213772
      0.390465
      0.395524
      0.364513
    
    
      30
      RRBS_trito_pool_2_CGTACTAG.CCTTCG
      0.0
      0.544424
      0.372864
      0.566449
      0.141793
      0.161766
      0.188699
      0.0
      0.188699
      0.320217
      0.520051
      0.648292
      0.287153
      0.134590
      0.231480
      0.918757
      0.808219
      0.556881
      0.786660
      0.0
      0.372677
      0.409840
      0.367423
      0.386818
      0.428182
      0.410043
      0.0
      0.410043
      0.437956
      0.431314
      0.417184
      0.370701
      0.403697
      0.379120
      0.132574
      0.402506
      0.408092
      0.392411
    
    
      31
      RRBS_trito_pool_2_CGTACTAG.CGGTAG
      0.0
      0.541543
      0.377491
      0.566615
      0.144500
      0.166361
      0.187541
      0.0
      0.187541
      0.323718
      0.570565
      0.649134
      0.290349
      0.139695
      0.231105
      0.875553
      0.805793
      0.574939
      0.781107
      0.0
      0.366749
      0.406201
      0.359577
      0.382439
      0.427216
      0.412182
      0.0
      0.412182
      0.424271
      0.326364
      0.387866
      0.358136
      0.400989
      0.367082
      0.233944
      0.405535
      0.387747
      0.372620
    
    
      32
      RRBS_trito_pool_2_CGTACTAG.CTATTG
      0.0
      0.571516
      0.403810
      0.595260
      0.147111
      0.169791
      0.199903
      0.0
      0.199903
      0.345774
      0.461720
      0.665058
      0.308691
      0.144474
      0.257436
      0.833091
      0.825356
      0.606750
      0.808127
      0.0
      0.352923
      0.389431
      0.346998
      0.367228
      0.410854
      0.408465
      0.0
      0.408465
      0.420192
      0.435325
      0.384775
      0.344882
      0.388064
      0.354390
      0.322671
      0.384292
      0.385328
      0.353731
    
    
      33
      RRBS_trito_pool_2_CGTACTAG.GACACG
      0.0
      0.547611
      0.384121
      0.571736
      0.141024
      0.160152
      0.183884
      0.0
      0.183884
      0.324428
      0.516251
      0.658554
      0.296090
      0.142236
      0.243037
      0.840847
      0.810208
      0.580500
      0.780899
      0.0
      0.362036
      0.396972
      0.355362
      0.379360
      0.423028
      0.407819
      0.0
      0.407819
      0.430720
      0.413402
      0.375936
      0.353105
      0.395058
      0.377523
      0.239142
      0.397595
      0.385070
      0.369290
    
    
      34
      RRBS_trito_pool_2_CGTACTAG.GCATTC
      0.0
      0.574308
      0.399926
      0.599169
      0.146626
      0.171425
      0.202222
      0.0
      0.202222
      0.339589
      0.601239
      0.673941
      0.311423
      0.142003
      0.251027
      0.900174
      0.822302
      0.607857
      0.804399
      0.0
      0.350723
      0.388557
      0.343231
      0.379437
      0.423172
      0.413884
      0.0
      0.413884
      0.430536
      0.484843
      0.385927
      0.351172
      0.395395
      0.377211
      0.260417
      0.387313
      0.379687
      0.352217
    
    
      35
      RRBS_trito_pool_2_CGTACTAG.GCTGCC
      0.0
      0.557827
      0.389318
      0.583295
      0.146131
      0.170323
      0.216651
      0.0
      0.216651
      0.332222
      0.465542
      0.685189
      0.303248
      0.142679
      0.253152
      0.925723
      0.812384
      0.566898
      0.789918
      0.0
      0.364344
      0.411073
      0.357567
      0.386643
      0.436352
      0.455234
      0.0
      0.455234
      0.427594
      0.441989
      0.410031
      0.357034
      0.414984
      0.377580
      0.122134
      0.390103
      0.391888
      0.356613
    
    
      36
      RRBS_trito_pool_2_CGTACTAG.GGCATC
      0.0
      0.558443
      0.393582
      0.581411
      0.149267
      0.173254
      0.202211
      0.0
      0.202211
      0.336075
      0.497985
      0.658613
      0.307422
      0.145063
      0.253500
      0.822348
      0.810850
      0.579463
      0.788819
      0.0
      0.369847
      0.416267
      0.362248
      0.393373
      0.438305
      0.432106
      0.0
      0.432106
      0.447392
      0.283823
      0.414114
      0.369362
      0.423329
      0.390531
      0.294508
      0.403624
      0.394708
      0.370958
    
    
      37
      RRBS_trito_pool_2_CGTACTAG.GTGAGG
      0.0
      0.548763
      0.378005
      0.573823
      0.146951
      0.166034
      0.189554
      0.0
      0.189554
      0.329531
      0.417063
      0.656924
      0.298588
      0.143700
      0.237655
      0.837979
      0.818187
      0.578995
      0.795407
      0.0
      0.369274
      0.411458
      0.362212
      0.399234
      0.439421
      0.426244
      0.0
      0.426244
      0.437661
      0.387644
      0.379763
      0.378844
      0.416184
      0.393381
      0.327526
      0.390663
      0.404334
      0.359301
    
    
      38
      RRBS_trito_pool_2_CGTACTAG.GTTGAG
      0.0
      0.560388
      0.392703
      0.585744
      0.148877
      0.173148
      0.191432
      0.0
      0.191432
      0.337372
      0.531839
      0.657189
      0.308189
      0.144341
      0.245608
      0.856433
      0.820191
      0.594452
      0.790093
      0.0
      0.357508
      0.399570
      0.348983
      0.382424
      0.428961
      0.426739
      0.0
      0.426739
      0.436677
      0.623022
      0.378906
      0.357031
      0.402640
      0.380493
      0.320648
      0.385596
      0.378942
      0.359409
    
    
      39
      RRBS_trito_pool_2_CGTACTAG.TAGCGG
      0.0
      0.542448
      0.379673
      0.565934
      0.141666
      0.161357
      0.190254
      0.0
      0.190254
      0.322077
      0.564060
      0.661459
      0.291782
      0.141023
      0.236705
      0.775427
      0.812801
      0.584395
      0.788413
      0.0
      0.373111
      0.419487
      0.363822
      0.398524
      0.443218
      0.429929
      0.0
      0.429929
      0.428916
      0.508213
      0.389595
      0.371629
      0.425177
      0.379944
      0.390322
      0.401379
      0.390136
      0.365038
    
  








    



In [37] used 0.168 MiB RAM in 0.210s, peaked 0.000 MiB above current, total RAM usage 106.270 MiB



In [38]:

    
stats = pd.read_csv("RRBS_anno_statistics_full_446files_filter50K.csv")









    



In [38] used 0.020 MiB RAM in 0.008s, peaked 0.000 MiB above current, total RAM usage 106.289 MiB



In [39]:

    
stats.shape









    Out[39]:





(446, 18)






    



In [39] used 0.000 MiB RAM in 0.003s, peaked 0.000 MiB above current, total RAM usage 106.289 MiB



In [40]:

    
stats_files = stats.filename









    



In [40] used 0.000 MiB RAM in 0.002s, peaked 0.000 MiB above current, total RAM usage 106.289 MiB



In [43]:

    
merged = stats.merge(total_region_files, on='filename')









    



In [43] used 0.246 MiB RAM in 0.023s, peaked 0.000 MiB above current, total RAM usage 108.641 MiB



In [46]:

    
merged = merged.drop(['thisMeth', 'mixedReadCount', 'total_reads', 'total_cpg_no_filter', 'total_cpg_gtrthan1',
       'total_cpg_gtrthan38', 'avgReadCpgs_nofilter','avgReadCpgs_lessthan1CpG', 'avgReadCpgs_gtreql3.8CpG', 'bsRate',], axis=1)









    



In [46] used 0.000 MiB RAM in 0.005s, peaked 0.000 MiB above current, total RAM usage 110.254 MiB



In [47]:

    
merged









    Out[47]:






  
    
      
      filename
      methylation
      PDR_total
      methylation_unweighted
      PDR_unweighted
      type
      bio
      protocol
      methylation_tssDistance
      methylation_genesDistance
      methylation_exonsDistance
      methylation_intronsDistance
      methylation_promoterDistance
      methylation_cgiDistance
      methylation_ctcfDistance
      methylation_ctcfUpDistance
      methylation_ctcfDownDistance
      methylation_geneDistalRegulatoryModulesDistance
      methylation_vistaEnhancersDistance
      methylation_3PrimeUTRDistance
      methylation_5PrimeUTRDistance
      methylation_firstExonDistance
      methylation_geneDistalRegulatoryModulesK562Distance
      methylation_hypoInHues64Distance
      methylation_intergenic
      methylation_shore
      methylation_shelf
      PDR_tssDistance
      PDR_genesDistance
      PDR_exonsDistance
      PDR_intronsDistance
      PDR_promoterDistance
      PDR_cgiDistance
      PDR_ctcfDistance
      PDR_ctcfUpDistance
      PDR_ctcfDownDistance
      PDR_geneDistalRegulatoryModulesDistance
      PDR_vistaEnhancersDistance
      PDR_3PrimeUTRDistance
      PDR_5PrimeUTRDistance
      PDR_firstExonDistance
      PDR_geneDistalRegulatoryModulesK562Distance
      PDR_hypoInHues64Distance
      PDR_intergenic
      PDR_shore
      PDR_shelf
    
  
  
    
      0
      RRBS_normal_B_cell_A1_24_TAAGGCGA.ACAACC
      0.591346
      0.259001
      0.691996
      0.254835
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.572922
      0.388607
      0.597003
      0.127235
      0.135145
      0.178152
      0.0
      0.178152
      0.313712
      0.354954
      0.728744
      0.282305
      0.125011
      0.230720
      0.926937
      0.902930
      0.637052
      0.896802
      0.0
      0.249665
      0.320241
      0.237896
      0.363833
      0.388255
      0.419154
      0.0
      0.419154
      0.364421
      0.489309
      0.214752
      0.295134
      0.379389
      0.352525
      0.020851
      0.183311
      0.285294
      0.169240
    
    
      1
      RRBS_normal_B_cell_A1_24_TAAGGCGA.ACCGCG
      0.531169
      0.411448
      0.620106
      0.390562
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.505145
      0.359230
      0.526446
      0.134970
      0.171891
      0.198475
      0.0
      0.198475
      0.352037
      0.516644
      0.625871
      0.266546
      0.123009
      0.233159
      0.865658
      0.777870
      0.528428
      0.750640
      0.0
      0.389613
      0.436141
      0.383879
      0.426575
      0.439299
      0.424045
      0.0
      0.424045
      0.468612
      0.632490
      0.413364
      0.384389
      0.446504
      0.426731
      0.016904
      0.426067
      0.413426
      0.430125
    
    
      2
      RRBS_normal_B_cell_A1_24_TAAGGCGA.ACGTGG
      0.586403
      0.278568
      0.699736
      0.266418
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.553568
      0.359975
      0.583731
      0.117959
      0.125268
      0.176109
      0.0
      0.176109
      0.309668
      0.712070
      0.718911
      0.277957
      0.101747
      0.227526
      0.942223
      0.895722
      0.618027
      0.868715
      0.0
      0.276292
      0.353180
      0.264764
      0.381896
      0.403526
      0.431742
      0.0
      0.431742
      0.362307
      0.148328
      0.312959
      0.323942
      0.389617
      0.349141
      0.150021
      0.199184
      0.311731
      0.206646
    
    
      3
      RRBS_normal_B_cell_A1_24_TAAGGCGA.AGGATG
      0.628623
      0.248006
      0.732036
      0.240201
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.600840
      0.392730
      0.633467
      0.130846
      0.134532
      0.228113
      0.0
      0.228113
      0.344969
      0.738883
      0.721101
      0.315410
      0.110561
      0.254307
      0.955880
      0.916222
      0.672012
      0.891286
      0.0
      0.242686
      0.329575
      0.226780
      0.380465
      0.395003
      0.428452
      0.0
      0.428452
      0.378543
      0.293278
      0.226409
      0.306003
      0.391967
      0.380095
      0.156554
      0.167441
      0.275408
      0.184916
    
    
      4
      RRBS_normal_B_cell_A1_24_TAAGGCGA.ATAGCG
      0.568354
      0.434929
      0.648127
      0.425702
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.553723
      0.424441
      0.572004
      0.201759
      0.254062
      0.243405
      0.0
      0.243405
      0.365090
      0.703915
      0.690610
      0.324217
      0.225215
      0.250693
      0.628902
      0.744224
      0.591154
      0.764444
      0.0
      0.396151
      0.413207
      0.393634
      0.414282
      0.434310
      0.404922
      0.0
      0.404922
      0.454559
      0.520165
      0.398875
      0.398097
      0.431908
      0.403162
      0.649024
      0.500065
      0.432751
      0.402732
    
    
      5
      RRBS_normal_B_cell_A1_24_TAAGGCGA.ATCGAC
      0.622386
      0.272543
      0.716552
      0.270967
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.598241
      0.400137
      0.625556
      0.135943
      0.142543
      0.197461
      0.0
      0.197461
      0.328983
      0.561384
      0.724674
      0.319542
      0.123392
      0.245854
      0.957901
      0.896857
      0.631902
      0.876983
      0.0
      0.263207
      0.329618
      0.253472
      0.378263
      0.392845
      0.387199
      0.0
      0.387199
      0.376833
      0.406406
      0.247637
      0.313278
      0.389120
      0.356423
      0.008145
      0.210394
      0.305067
      0.196524
    
    
      6
      RRBS_normal_B_cell_A1_24_TAAGGCGA.CAAGAG
      0.580746
      0.358441
      0.670718
      0.348679
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.557673
      0.393037
      0.581964
      0.136496
      0.154840
      0.185085
      0.0
      0.185085
      0.336342
      0.548913
      0.724639
      0.289102
      0.134083
      0.242662
      0.914303
      0.839622
      0.609142
      0.828499
      0.0
      0.346284
      0.400937
      0.334616
      0.403498
      0.421695
      0.446341
      0.0
      0.446341
      0.415259
      0.457161
      0.375382
      0.381060
      0.431724
      0.366805
      0.323921
      0.349326
      0.361848
      0.326459
    
    
      7
      RRBS_normal_B_cell_A1_24_TAAGGCGA.CATGAC
      0.579873
      0.374401
      0.668592
      0.364613
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.555496
      0.372118
      0.585104
      0.130767
      0.149758
      0.174434
      0.0
      0.174434
      0.325693
      0.489904
      0.691227
      0.303725
      0.117398
      0.252648
      0.877326
      0.830718
      0.612466
      0.819436
      0.0
      0.352702
      0.397442
      0.342892
      0.398493
      0.420841
      0.398592
      0.0
      0.398592
      0.433256
      0.586659
      0.322179
      0.351247
      0.405937
      0.401367
      0.420977
      0.381797
      0.388051
      0.361306
    
    
      8
      RRBS_normal_B_cell_A1_24_TAAGGCGA.CGGTAG
      0.580833
      0.285978
      0.701418
      0.271634
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.547152
      0.343528
      0.574055
      0.117823
      0.121103
      0.155409
      0.0
      0.155409
      0.304843
      0.593398
      0.648511
      0.280638
      0.096895
      0.228697
      0.986942
      0.887179
      0.600183
      0.863762
      0.0
      0.280334
      0.358519
      0.267715
      0.392784
      0.396120
      0.372254
      0.0
      0.372254
      0.399106
      0.174794
      0.363332
      0.337774
      0.402650
      0.366518
      0.060128
      0.231404
      0.321895
      0.210547
    
    
      9
      RRBS_normal_B_cell_A1_24_TAAGGCGA.CTATTG
      0.582590
      0.427069
      0.650146
      0.424804
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.569780
      0.422603
      0.591459
      0.171423
      0.213337
      0.222178
      0.0
      0.222178
      0.366234
      0.698103
      0.685389
      0.327695
      0.170005
      0.263775
      0.864895
      0.775154
      0.610494
      0.773103
      0.0
      0.393549
      0.428448
      0.389104
      0.421122
      0.442946
      0.424529
      0.0
      0.424529
      0.465571
      0.501746
      0.424570
      0.388460
      0.445857
      0.430022
      0.365360
      0.478388
      0.410114
      0.419770
    
    
      10
      RRBS_normal_B_cell_A1_24_TAAGGCGA.CTCAGC
      0.577931
      0.441120
      0.640678
      0.433420
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.565528
      0.437396
      0.585564
      0.207370
      0.274443
      0.235145
      0.0
      0.235145
      0.377706
      0.636860
      0.669217
      0.337121
      0.216485
      0.247102
      0.909352
      0.737474
      0.578117
      0.735609
      0.0
      0.409112
      0.426369
      0.406486
      0.421935
      0.442577
      0.428453
      0.0
      0.428453
      0.502348
      0.678498
      0.373862
      0.418496
      0.439376
      0.451782
      0.296798
      0.502111
      0.430704
      0.404902
    
    
      11
      RRBS_normal_B_cell_A1_24_TAAGGCGA.GACACG
      0.603615
      0.259780
      0.705313
      0.246132
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.568850
      0.361969
      0.599111
      0.122396
      0.127940
      0.159862
      0.0
      0.159862
      0.320582
      0.725028
      0.694968
      0.304324
      0.117228
      0.238581
      0.971203
      0.898648
      0.616594
      0.874494
      0.0
      0.259987
      0.346939
      0.247972
      0.376738
      0.384038
      0.371028
      0.0
      0.371028
      0.370863
      0.041421
      0.276435
      0.305850
      0.396597
      0.374203
      0.122058
      0.193916
      0.294751
      0.178923
    
    
      12
      RRBS_normal_B_cell_A1_24_TAAGGCGA.GCTGCC
      0.602191
      0.274941
      0.696495
      0.261564
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.569876
      0.362369
      0.602931
      0.119385
      0.123399
      0.166912
      0.0
      0.166912
      0.312508
      0.483566
      0.664175
      0.295046
      0.104887
      0.227071
      0.888816
      0.894996
      0.621557
      0.873106
      0.0
      0.270732
      0.350990
      0.255018
      0.379740
      0.403785
      0.393961
      0.0
      0.393961
      0.374419
      0.151892
      0.287812
      0.327504
      0.390677
      0.347520
      0.373774
      0.199908
      0.307455
      0.208747
    
    
      13
      RRBS_normal_B_cell_A1_24_TAAGGCGA.GGCATC
      0.592896
      0.309917
      0.688324
      0.293166
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.568737
      0.375639
      0.597084
      0.126210
      0.134600
      0.173529
      0.0
      0.173529
      0.311749
      0.609371
      0.670949
      0.303669
      0.104746
      0.230130
      0.933383
      0.874730
      0.619164
      0.858757
      0.0
      0.302826
      0.370106
      0.290653
      0.398204
      0.419242
      0.411253
      0.0
      0.411253
      0.405264
      0.556019
      0.334586
      0.327526
      0.392053
      0.379147
      0.134353
      0.259203
      0.328873
      0.271502
    
    
      14
      RRBS_normal_B_cell_A1_24_TAAGGCGA.GTGAGG
      0.576342
      0.269746
      0.692209
      0.255067
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.543913
      0.345264
      0.578228
      0.119943
      0.117022
      0.186957
      0.0
      0.186957
      0.304374
      0.275972
      0.686426
      0.258585
      0.103817
      0.243962
      0.973117
      0.893765
      0.601321
      0.862469
      0.0
      0.269974
      0.351114
      0.255608
      0.384957
      0.398879
      0.421579
      0.0
      0.421579
      0.369955
      0.324316
      0.242306
      0.326748
      0.397716
      0.360025
      0.077235
      0.189490
      0.295756
      0.182461
    
    
      15
      RRBS_normal_B_cell_A1_24_TAAGGCGA.GTTGAG
      0.573082
      0.434043
      0.645717
      0.421790
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.567695
      0.412468
      0.587454
      0.152377
      0.169104
      0.213248
      0.0
      0.213248
      0.325752
      0.478594
      0.672947
      0.300417
      0.138325
      0.267002
      0.718321
      0.755050
      0.585532
      0.768680
      0.0
      0.394381
      0.413518
      0.390813
      0.422574
      0.436592
      0.393126
      0.0
      0.393126
      0.423319
      0.545367
      0.442718
      0.413598
      0.426612
      0.399205
      0.439942
      0.496714
      0.422975
      0.392376
    
    
      16
      RRBS_normal_B_cell_A1_24_TAAGGCGA.TAGCGG
      0.563537
      0.344400
      0.671286
      0.324550
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.537509
      0.353348
      0.562371
      0.118371
      0.130877
      0.170794
      0.0
      0.170794
      0.303084
      0.460163
      0.660977
      0.281453
      0.108285
      0.226112
      0.777019
      0.856849
      0.597661
      0.836136
      0.0
      0.334426
      0.403578
      0.325768
      0.395605
      0.424208
      0.433552
      0.0
      0.433552
      0.385425
      0.504680
      0.365191
      0.353273
      0.424782
      0.364329
      0.507417
      0.312744
      0.359828
      0.303938
    
    
      17
      RRBS_normal_B_cell_A1_24_TAAGGCGA.TATCTC
      0.592870
      0.383162
      0.663549
      0.384798
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.574181
      0.422529
      0.596448
      0.157292
      0.185985
      0.197790
      0.0
      0.197790
      0.333505
      0.549745
      0.695153
      0.306368
      0.162632
      0.244439
      0.958932
      0.817648
      0.615515
      0.796791
      0.0
      0.359375
      0.390368
      0.355666
      0.395329
      0.415846
      0.400304
      0.0
      0.400304
      0.420615
      0.631283
      0.386431
      0.353516
      0.402680
      0.372923
      0.120302
      0.406370
      0.387130
      0.361715
    
    
      18
      RRBS_normal_B_cell_A1_24_TAAGGCGA.TCTCTG
      0.566829
      0.459303
      0.621230
      0.456004
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.561735
      0.445770
      0.575198
      0.219102
      0.270627
      0.262653
      0.0
      0.262653
      0.388225
      0.425444
      0.658489
      0.339626
      0.221938
      0.268746
      0.693445
      0.707242
      0.582715
      0.734725
      0.0
      0.424692
      0.428625
      0.423983
      0.416932
      0.438851
      0.435457
      0.0
      0.435457
      0.458630
      0.506799
      0.461580
      0.424516
      0.410753
      0.402906
      0.446482
      0.535373
      0.447916
      0.449113
    
    
      19
      RRBS_normal_B_cell_A1_24_TAAGGCGA.TGACAG
      0.572760
      0.339617
      0.670456
      0.330762
      normal
      normal_B
      normal_B_cell_A1_24
      0.0
      0.545209
      0.366002
      0.571545
      0.129616
      0.136915
      0.184688
      0.0
      0.184688
      0.302508
      0.516610
      0.667369
      0.283649
      0.109472
      0.226291
      0.815052
      0.858191
      0.595584
      0.824065
      0.0
      0.328561
      0.362106
      0.322815
      0.385218
      0.409109
      0.420144
      0.0
      0.420144
      0.416980
      0.540203
      0.342566
      0.359376
      0.387962
      0.391970
      0.426135
      0.310284
      0.363570
      0.329527
    
    
      20
      RRBS_normal_B_cell_B1_24_CGTACTAG.ACAACC
      0.626281
      0.266847
      0.723172
      0.246680
      normal
      normal_B
      normal_B_cell_B1_24
      0.0
      0.600708
      0.393908
      0.630897
      0.130491
      0.132780
      0.202374
      0.0
      0.202374
      0.352837
      0.713675
      0.725713
      0.320354
      0.106622
      0.268270
      0.927542
      0.898352
      0.640993
      0.877308
      0.0
      0.259897
      0.334198
      0.248877
      0.382296
      0.401650
      0.425809
      0.0
      0.425809
      0.382371
      0.255144
      0.252366
      0.309392
      0.380196
      0.367431
      0.180845
      0.201513
      0.301175
      0.213756
    
    
      21
      RRBS_normal_B_cell_B1_24_CGTACTAG.ACCGCG
      0.537494
      0.432684
      0.620718
      0.409340
      normal
      normal_B
      normal_B_cell_B1_24
      0.0
      0.519674
      0.378490
      0.541383
      0.159885
      0.190980
      0.207475
      0.0
      0.207475
      0.318937
      0.704963
      0.615859
      0.290296
      0.155550
      0.229599
      0.820416
      0.733765
      0.532819
      0.736470
      0.0
      0.398962
      0.428732
      0.396038
      0.410177
      0.437335
      0.420623
      0.0
      0.420623
      0.464244
      0.680829
      0.429482
      0.377868
      0.416697
      0.435796
      0.262760
      0.487506
      0.420668
      0.395321
    
    
      22
      RRBS_normal_B_cell_B1_24_CGTACTAG.ACTCAC
      0.641663
      0.246022
      0.731753
      0.227309
      normal
      normal_B
      normal_B_cell_B1_24
      0.0
      0.612460
      0.404062
      0.641619
      0.138321
      0.134888
      0.200057
      0.0
      0.200057
      0.365257
      0.464153
      0.743855
      0.331324
      0.115728
      0.271711
      0.888724
      0.914558
      0.655884
      0.902320
      0.0
      0.242492
      0.329096
      0.230329
      0.387293
      0.406756
      0.409925
      0.0
      0.409925
      0.381945
      0.411628
      0.222693
      0.307246
      0.402911
      0.373759
      0.088080
      0.165203
      0.278304
      0.167580
    
    
      23
      RRBS_normal_B_cell_B1_24_CGTACTAG.ATAGCG
      0.589376
      0.261165
      0.710628
      0.230766
      normal
      normal_B
      normal_B_cell_B1_24
      0.0
      0.564847
      0.359529
      0.595146
      0.118704
      0.114490
      0.173252
      0.0
      0.173252
      0.310655
      0.503806
      0.691586
      0.285765
      0.103678
      0.228965
      0.970596
      0.901415
      0.619064
      0.889049
      0.0
      0.258756
      0.349989
      0.242980
      0.378504
      0.394998
      0.419274
      0.0
      0.419274
      0.350099
      0.564988
      0.274140
      0.311913
      0.397878
      0.335510
      0.049096
      0.181269
      0.296877
      0.184334
    
    
      24
      RRBS_normal_B_cell_B1_24_CGTACTAG.CAAGAG
      0.573636
      0.410016
      0.649119
      0.394524
      normal
      normal_B
      normal_B_cell_B1_24
      0.0
      0.558144
      0.410151
      0.580173
      0.160099
      0.195220
      0.200590
      0.0
      0.200590
      0.349321
      0.549857
      0.668894
      0.309413
      0.163017
      0.243278
      0.919356
      0.784926
      0.568173
      0.761311
      0.0
      0.386441
      0.419907
      0.381549
      0.411113
      0.441415
      0.406298
      0.0
      0.406298
      0.448031
      0.547251
      0.410927
      0.394507
      0.435718
      0.393209
      0.308112
      0.437090
      0.407888
      0.396319
    
    
      25
      RRBS_normal_B_cell_B1_24_CGTACTAG.CATGAC
      0.624309
      0.250108
      0.726315
      0.228687
      normal
      normal_B
      normal_B_cell_B1_24
      0.0
      0.596158
      0.388236
      0.627931
      0.130745
      0.131519
      0.172315
      0.0
      0.172315
      0.338750
      0.456898
      0.722962
      0.315504
      0.112215
      0.257224
      0.969047
      0.914006
      0.639293
      0.894982
      0.0
      0.248352
      0.341477
      0.232416
      0.376812
      0.406716
      0.399623
      0.0
      0.399623
      0.368001
      0.332834
      0.242602
      0.312927
      0.398130
      0.356175
      0.101891
      0.168523
      0.281624
      0.169076
    
    
      26
      RRBS_normal_B_cell_B1_24_CGTACTAG.CCTTCG
      0.596452
      0.329267
      0.698844
      0.306790
      normal
      normal_B
      normal_B_cell_B1_24
      0.0
      0.571273
      0.377748
      0.599836
      0.130880
      0.142904
      0.178021
      0.0
      0.178021
      0.331112
      0.590600
      0.684578
      0.300336
      0.120516
      0.255226
      0.910927
      0.858774
      0.607147
      0.851038
      0.0
      0.313604
      0.385012
      0.301194
      0.409911
      0.429555
      0.440444
      0.0
      0.440444
      0.411064
      0.403216
      0.356594
      0.351884
      0.427722
      0.393187
      0.197940
      0.299706
      0.348462
      0.263281
    
    
      27
      RRBS_normal_B_cell_B1_24_CGTACTAG.CGGTAG
      0.525054
      0.433851
      0.609985
      0.410107
      normal
      normal_B
      normal_B_cell_B1_24
      0.0
      0.507179
      0.348300
      0.529348
      0.131065
      0.146562
      0.159320
      0.0
      0.159320
      0.291927
      0.585224
      0.598317
      0.271001
      0.122086
      0.204311
      0.831863
      0.748557
      0.519638
      0.731533
      0.0
      0.407883
      0.431943
      0.402297
      0.405059
      0.427618
      0.414400
      0.0
      0.414400
      0.426879
      0.483459
      0.421985
      0.395431
      0.423924
      0.373547
      0.410587
      0.484246
      0.438821
      0.430328
    
    
      28
      RRBS_normal_B_cell_B1_24_CGTACTAG.CTATTG
      0.593262
      0.424328
      0.660035
      0.416186
      normal
      normal_B
      normal_B_cell_B1_24
      0.0
      0.579434
      0.434890
      0.600699
      0.188624
      0.233725
      0.230526
      0.0
      0.230526
      0.366878
      0.612085
      0.672638
      0.334540
      0.186837
      0.249289
      0.849944
      0.774006
      0.594751
      0.778275
      0.0
      0.393161
      0.420478
      0.388782
      0.413085
      0.445061
      0.400803
      0.0
      0.400803
      0.437013
      0.527192
      0.421103
      0.396852
      0.430744
      0.381902
      0.351360
      0.469681
      0.420649
      0.397929
    
    
      29
      RRBS_normal_B_cell_B1_24_CGTACTAG.CTCAGC
      0.615582
      0.270868
      0.718351
      0.245807
      normal
      normal_B
      normal_B_cell_B1_24
      0.0
      0.584390
      0.381342
      0.614639
      0.128080
      0.134331
      0.181411
      0.0
      0.181411
      0.326547
      0.521315
      0.699421
      0.307323
      0.114798
      0.250506
      0.958901
      0.900439
      0.617142
      0.875827
      0.0
      0.267871
      0.351355
      0.252870
      0.389412
      0.415080
      0.433702
      0.0
      0.433702
      0.390515
      0.388477
      0.260598
      0.320489
      0.397438
      0.368093
      0.046859
      0.194196
      0.307630
      0.192950
    
    
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
    
    
      416
      RRBS_trito_pool_1_TAAGGCGA.GCTGCC
      0.565787
      0.379120
      0.636582
      0.361267
      CLL
      CLL
      trito_pool_1
      0.0
      0.544259
      0.384439
      0.564795
      0.139736
      0.162409
      0.176248
      0.0
      0.176248
      0.318136
      0.574486
      0.634002
      0.289043
      0.139641
      0.223191
      0.856793
      0.800237
      0.554718
      0.776976
      0.0
      0.354565
      0.388414
      0.347581
      0.360744
      0.402607
      0.390989
      0.0
      0.390989
      0.431375
      0.409462
      0.385777
      0.340581
      0.375888
      0.372911
      0.350551
      0.400626
      0.404546
      0.364278
    
    
      417
      RRBS_trito_pool_1_TAAGGCGA.GGCATC
      0.578365
      0.372803
      0.639499
      0.362328
      CLL
      CLL
      trito_pool_1
      0.0
      0.555539
      0.392705
      0.579332
      0.145652
      0.164935
      0.184172
      0.0
      0.184172
      0.333482
      0.421168
      0.661779
      0.296269
      0.147555
      0.241141
      0.825601
      0.813275
      0.589382
      0.790102
      0.0
      0.349269
      0.378454
      0.343167
      0.352282
      0.398483
      0.383984
      0.0
      0.383984
      0.394837
      0.570345
      0.396641
      0.337457
      0.375483
      0.341387
      0.228666
      0.393968
      0.384816
      0.358044
    
    
      418
      RRBS_trito_pool_1_TAAGGCGA.GTGAGG
      0.554707
      0.379959
      0.630143
      0.365870
      CLL
      CLL
      trito_pool_1
      0.0
      0.530569
      0.367508
      0.554714
      0.134121
      0.155524
      0.173857
      0.0
      0.173857
      0.315881
      0.463581
      0.615143
      0.280369
      0.133060
      0.232378
      0.794342
      0.804363
      0.553666
      0.777878
      0.0
      0.358688
      0.390493
      0.351879
      0.361701
      0.404384
      0.398420
      0.0
      0.398420
      0.422339
      0.427769
      0.417731
      0.341625
      0.380159
      0.367890
      0.326313
      0.400965
      0.391422
      0.373351
    
    
      419
      RRBS_trito_pool_1_TAAGGCGA.GTTGAG
      0.581650
      0.365969
      0.651666
      0.354063
      CLL
      CLL
      trito_pool_1
      0.0
      0.557958
      0.396493
      0.580842
      0.143581
      0.165943
      0.198223
      0.0
      0.198223
      0.335718
      0.511515
      0.653486
      0.294972
      0.142042
      0.251258
      0.808442
      0.821536
      0.592957
      0.795827
      0.0
      0.344146
      0.371379
      0.337804
      0.354805
      0.397635
      0.404505
      0.0
      0.404505
      0.420580
      0.415804
      0.359175
      0.330021
      0.365134
      0.366449
      0.413398
      0.375629
      0.381035
      0.346115
    
    
      420
      RRBS_trito_pool_1_TAAGGCGA.TAGCGG
      0.564165
      0.368605
      0.635522
      0.354078
      CLL
      CLL
      trito_pool_1
      0.0
      0.540878
      0.368191
      0.564637
      0.133724
      0.153977
      0.166738
      0.0
      0.166738
      0.307876
      0.486900
      0.632573
      0.286827
      0.128397
      0.230826
      0.856077
      0.814219
      0.577274
      0.793247
      0.0
      0.346260
      0.378683
      0.339097
      0.356597
      0.396187
      0.381571
      0.0
      0.381571
      0.400928
      0.570090
      0.362619
      0.339981
      0.379723
      0.344153
      0.377799
      0.385887
      0.384042
      0.349956
    
    
      421
      RRBS_trito_pool_1_TAAGGCGA.TATCTC
      0.598086
      0.365747
      0.640908
      0.360269
      CLL
      CLL
      trito_pool_1
      0.0
      0.575676
      0.409355
      0.600599
      0.148591
      0.174386
      0.194566
      0.0
      0.194566
      0.336279
      0.554679
      0.662141
      0.309579
      0.142574
      0.240360
      0.844196
      0.822712
      0.607978
      0.806099
      0.0
      0.341342
      0.367808
      0.337694
      0.339362
      0.386849
      0.380734
      0.0
      0.380734
      0.394130
      0.514109
      0.395076
      0.319727
      0.356904
      0.318327
      0.309309
      0.390633
      0.376339
      0.360353
    
    
      422
      RRBS_trito_pool_1_TAAGGCGA.TCTCTG
      0.598637
      0.367210
      0.649959
      0.358410
      CLL
      CLL
      trito_pool_1
      0.0
      0.573932
      0.402771
      0.597337
      0.153348
      0.175088
      0.200765
      0.0
      0.200765
      0.347808
      0.610443
      0.676611
      0.311039
      0.144939
      0.256872
      0.854733
      0.826905
      0.607012
      0.802475
      0.0
      0.342377
      0.370775
      0.337035
      0.356039
      0.402495
      0.412892
      0.0
      0.412892
      0.408307
      0.464521
      0.389068
      0.330017
      0.366829
      0.337809
      0.241373
      0.383198
      0.378137
      0.345602
    
    
      423
      RRBS_trito_pool_1_TAAGGCGA.TGACAG
      0.592655
      0.364070
      0.651817
      0.350381
      CLL
      CLL
      trito_pool_1
      0.0
      0.567869
      0.399077
      0.591561
      0.148038
      0.176237
      0.202154
      0.0
      0.202154
      0.343355
      0.522213
      0.665558
      0.303592
      0.146534
      0.252288
      0.796484
      0.830742
      0.598186
      0.806577
      0.0
      0.345410
      0.381678
      0.340699
      0.363333
      0.411799
      0.398106
      0.0
      0.398106
      0.406224
      0.468663
      0.352417
      0.345042
      0.391606
      0.339766
      0.370686
      0.369564
      0.369690
      0.345702
    
    
      424
      RRBS_trito_pool_1_TAAGGCGA.TGCTGC
      0.572118
      0.380804
      0.638604
      0.366845
      CLL
      CLL
      trito_pool_1
      0.0
      0.549810
      0.381938
      0.576183
      0.143244
      0.162055
      0.182065
      0.0
      0.182065
      0.322882
      0.522536
      0.636949
      0.297776
      0.142530
      0.244198
      0.808005
      0.807068
      0.566512
      0.789342
      0.0
      0.361772
      0.392851
      0.356422
      0.365182
      0.413081
      0.408349
      0.0
      0.408349
      0.431775
      0.422301
      0.386494
      0.344547
      0.390997
      0.368241
      0.364905
      0.392520
      0.386162
      0.373449
    
    
      425
      RRBS_trito_pool_2_CGTACTAG.ACAACC
      0.593766
      0.374765
      0.655123
      0.357956
      CLL
      CLL
      trito_pool_2
      0.0
      0.571434
      0.403317
      0.595518
      0.150534
      0.172412
      0.197820
      0.0
      0.197820
      0.335046
      0.542060
      0.674691
      0.311226
      0.145333
      0.251228
      0.782911
      0.825876
      0.601882
      0.804140
      0.0
      0.356830
      0.396188
      0.349903
      0.388446
      0.425970
      0.423147
      0.0
      0.423147
      0.414028
      0.406933
      0.353024
      0.363997
      0.410352
      0.353075
      0.404312
      0.376888
      0.385532
      0.352623
    
    
      426
      RRBS_trito_pool_2_CGTACTAG.ACGTGG
      0.569259
      0.388716
      0.648626
      0.369196
      CLL
      CLL
      trito_pool_2
      0.0
      0.547223
      0.381861
      0.572699
      0.142991
      0.167937
      0.187875
      0.0
      0.187875
      0.322376
      0.494384
      0.655945
      0.290386
      0.138317
      0.228471
      0.824135
      0.809657
      0.575763
      0.782319
      0.0
      0.367896
      0.410155
      0.360025
      0.392362
      0.439690
      0.423503
      0.0
      0.423503
      0.424893
      0.371724
      0.396436
      0.364995
      0.415006
      0.358457
      0.266702
      0.393868
      0.396684
      0.361810
    
    
      427
      RRBS_trito_pool_2_CGTACTAG.ACTCAC
      0.595647
      0.380070
      0.652962
      0.364404
      CLL
      CLL
      trito_pool_2
      0.0
      0.574078
      0.410369
      0.599662
      0.154807
      0.180722
      0.204649
      0.0
      0.204649
      0.346719
      0.484916
      0.687740
      0.314513
      0.155080
      0.260803
      0.812211
      0.828639
      0.608617
      0.812883
      0.0
      0.360783
      0.413536
      0.352271
      0.396930
      0.438502
      0.437218
      0.0
      0.437218
      0.434233
      0.243128
      0.391187
      0.371005
      0.424675
      0.381663
      0.401646
      0.380932
      0.388726
      0.364671
    
    
      428
      RRBS_trito_pool_2_CGTACTAG.AGGATG
      0.595616
      0.384004
      0.658358
      0.369689
      CLL
      CLL
      trito_pool_2
      0.0
      0.574464
      0.411157
      0.598317
      0.153244
      0.179052
      0.205426
      0.0
      0.205426
      0.347422
      0.549476
      0.674730
      0.318179
      0.150916
      0.255366
      0.825079
      0.819016
      0.600086
      0.803518
      0.0
      0.361346
      0.394711
      0.356405
      0.385541
      0.430138
      0.435397
      0.0
      0.435397
      0.430261
      0.509647
      0.397243
      0.354870
      0.405106
      0.376955
      0.349346
      0.390618
      0.387689
      0.355591
    
    
      429
      RRBS_trito_pool_2_CGTACTAG.ATAGCG
      0.554055
      0.387759
      0.635741
      0.364157
      CLL
      CLL
      trito_pool_2
      0.0
      0.530317
      0.372598
      0.555500
      0.139056
      0.162002
      0.188584
      0.0
      0.188584
      0.314593
      0.662600
      0.651363
      0.276445
      0.139170
      0.226507
      0.782103
      0.805115
      0.577048
      0.796431
      0.0
      0.368334
      0.399350
      0.363279
      0.375962
      0.421184
      0.422536
      0.0
      0.422536
      0.423652
      0.422062
      0.390546
      0.352241
      0.394821
      0.362621
      0.349869
      0.400868
      0.397587
      0.375378
    
    
      430
      RRBS_trito_pool_2_CGTACTAG.ATCGAC
      0.598233
      0.384663
      0.661048
      0.366513
      CLL
      CLL
      trito_pool_2
      0.0
      0.579706
      0.417754
      0.601652
      0.154766
      0.179131
      0.214474
      0.0
      0.214474
      0.347695
      0.592746
      0.693724
      0.318722
      0.152873
      0.251772
      0.829067
      0.818502
      0.603463
      0.804070
      0.0
      0.365534
      0.410172
      0.359211
      0.392262
      0.438666
      0.432635
      0.0
      0.432635
      0.437134
      0.550723
      0.406531
      0.367066
      0.412751
      0.381165
      0.291126
      0.388891
      0.385826
      0.368804
    
    
      431
      RRBS_trito_pool_2_CGTACTAG.CAAGAG
      0.583609
      0.393008
      0.649029
      0.373233
      CLL
      CLL
      trito_pool_2
      0.0
      0.562102
      0.395170
      0.587195
      0.146861
      0.171793
      0.193740
      0.0
      0.193740
      0.336475
      0.643228
      0.644603
      0.303090
      0.145796
      0.249175
      0.867900
      0.811712
      0.594372
      0.798705
      0.0
      0.371383
      0.417443
      0.364244
      0.392824
      0.439427
      0.424017
      0.0
      0.424017
      0.430895
      0.419896
      0.406159
      0.358254
      0.421774
      0.375869
      0.285465
      0.405000
      0.385932
      0.366543
    
    
      432
      RRBS_trito_pool_2_CGTACTAG.CATGAC
      0.593843
      0.383170
      0.659853
      0.366034
      CLL
      CLL
      trito_pool_2
      0.0
      0.572795
      0.406324
      0.595511
      0.149580
      0.173139
      0.207084
      0.0
      0.207084
      0.341760
      0.582188
      0.686507
      0.311526
      0.145188
      0.255092
      0.898922
      0.822096
      0.602356
      0.802416
      0.0
      0.363315
      0.403748
      0.356727
      0.385169
      0.426971
      0.428521
      0.0
      0.428521
      0.437559
      0.666602
      0.399967
      0.360502
      0.402785
      0.382317
      0.213772
      0.390465
      0.395524
      0.364513
    
    
      433
      RRBS_trito_pool_2_CGTACTAG.CCTTCG
      0.568050
      0.392622
      0.647402
      0.371530
      CLL
      CLL
      trito_pool_2
      0.0
      0.544424
      0.372864
      0.566449
      0.141793
      0.161766
      0.188699
      0.0
      0.188699
      0.320217
      0.520051
      0.648292
      0.287153
      0.134590
      0.231480
      0.918757
      0.808219
      0.556881
      0.786660
      0.0
      0.372677
      0.409840
      0.367423
      0.386818
      0.428182
      0.410043
      0.0
      0.410043
      0.437956
      0.431314
      0.417184
      0.370701
      0.403697
      0.379120
      0.132574
      0.402506
      0.408092
      0.392411
    
    
      434
      RRBS_trito_pool_2_CGTACTAG.CGGTAG
      0.569010
      0.390108
      0.645339
      0.372348
      CLL
      CLL
      trito_pool_2
      0.0
      0.541543
      0.377491
      0.566615
      0.144500
      0.166361
      0.187541
      0.0
      0.187541
      0.323718
      0.570565
      0.649134
      0.290349
      0.139695
      0.231105
      0.875553
      0.805793
      0.574939
      0.781107
      0.0
      0.366749
      0.406201
      0.359577
      0.382439
      0.427216
      0.412182
      0.0
      0.412182
      0.424271
      0.326364
      0.387866
      0.358136
      0.400989
      0.367082
      0.233944
      0.405535
      0.387747
      0.372620
    
    
      435
      RRBS_trito_pool_2_CGTACTAG.CTATTG
      0.595037
      0.373701
      0.659609
      0.357034
      CLL
      CLL
      trito_pool_2
      0.0
      0.571516
      0.403810
      0.595260
      0.147111
      0.169791
      0.199903
      0.0
      0.199903
      0.345774
      0.461720
      0.665058
      0.308691
      0.144474
      0.257436
      0.833091
      0.825356
      0.606750
      0.808127
      0.0
      0.352923
      0.389431
      0.346998
      0.367228
      0.410854
      0.408465
      0.0
      0.408465
      0.420192
      0.435325
      0.384775
      0.344882
      0.388064
      0.354390
      0.322671
      0.384292
      0.385328
      0.353731
    
    
      436
      RRBS_trito_pool_2_CGTACTAG.GACACG
      0.570886
      0.384283
      0.645343
      0.367303
      CLL
      CLL
      trito_pool_2
      0.0
      0.547611
      0.384121
      0.571736
      0.141024
      0.160152
      0.183884
      0.0
      0.183884
      0.324428
      0.516251
      0.658554
      0.296090
      0.142236
      0.243037
      0.840847
      0.810208
      0.580500
      0.780899
      0.0
      0.362036
      0.396972
      0.355362
      0.379360
      0.423028
      0.407819
      0.0
      0.407819
      0.430720
      0.413402
      0.375936
      0.353105
      0.395058
      0.377523
      0.239142
      0.397595
      0.385070
      0.369290
    
    
      437
      RRBS_trito_pool_2_CGTACTAG.GCATTC
      0.596410
      0.375766
      0.656557
      0.357551
      CLL
      CLL
      trito_pool_2
      0.0
      0.574308
      0.399926
      0.599169
      0.146626
      0.171425
      0.202222
      0.0
      0.202222
      0.339589
      0.601239
      0.673941
      0.311423
      0.142003
      0.251027
      0.900174
      0.822302
      0.607857
      0.804399
      0.0
      0.350723
      0.388557
      0.343231
      0.379437
      0.423172
      0.413884
      0.0
      0.413884
      0.430536
      0.484843
      0.385927
      0.351172
      0.395395
      0.377211
      0.260417
      0.387313
      0.379687
      0.352217
    
    
      438
      RRBS_trito_pool_2_CGTACTAG.GCTGCC
      0.583331
      0.384057
      0.650519
      0.361400
      CLL
      CLL
      trito_pool_2
      0.0
      0.557827
      0.389318
      0.583295
      0.146131
      0.170323
      0.216651
      0.0
      0.216651
      0.332222
      0.465542
      0.685189
      0.303248
      0.142679
      0.253152
      0.925723
      0.812384
      0.566898
      0.789918
      0.0
      0.364344
      0.411073
      0.357567
      0.386643
      0.436352
      0.455234
      0.0
      0.455234
      0.427594
      0.441989
      0.410031
      0.357034
      0.414984
      0.377580
      0.122134
      0.390103
      0.391888
      0.356613
    
    
      439
      RRBS_trito_pool_2_CGTACTAG.GGCATC
      0.583463
      0.392946
      0.648295
      0.372514
      CLL
      CLL
      trito_pool_2
      0.0
      0.558443
      0.393582
      0.581411
      0.149267
      0.173254
      0.202211
      0.0
      0.202211
      0.336075
      0.497985
      0.658613
      0.307422
      0.145063
      0.253500
      0.822348
      0.810850
      0.579463
      0.788819
      0.0
      0.369847
      0.416267
      0.362248
      0.393373
      0.438305
      0.432106
      0.0
      0.432106
      0.447392
      0.283823
      0.414114
      0.369362
      0.423329
      0.390531
      0.294508
      0.403624
      0.394708
      0.370958
    
    
      440
      RRBS_trito_pool_2_CGTACTAG.GTGAGG
      0.572670
      0.387705
      0.655986
      0.366706
      CLL
      CLL
      trito_pool_2
      0.0
      0.548763
      0.378005
      0.573823
      0.146951
      0.166034
      0.189554
      0.0
      0.189554
      0.329531
      0.417063
      0.656924
      0.298588
      0.143700
      0.237655
      0.837979
      0.818187
      0.578995
      0.795407
      0.0
      0.369274
      0.411458
      0.362212
      0.399234
      0.439421
      0.426244
      0.0
      0.426244
      0.437661
      0.387644
      0.379763
      0.378844
      0.416184
      0.393381
      0.327526
      0.390663
      0.404334
      0.359301
    
    
      441
      RRBS_trito_pool_2_CGTACTAG.GTTGAG
      0.584506
      0.379222
      0.659633
      0.362664
      CLL
      CLL
      trito_pool_2
      0.0
      0.560388
      0.392703
      0.585744
      0.148877
      0.173148
      0.191432
      0.0
      0.191432
      0.337372
      0.531839
      0.657189
      0.308189
      0.144341
      0.245608
      0.856433
      0.820191
      0.594452
      0.790093
      0.0
      0.357508
      0.399570
      0.348983
      0.382424
      0.428961
      0.426739
      0.0
      0.426739
      0.436677
      0.623022
      0.378906
      0.357031
      0.402640
      0.380493
      0.320648
      0.385596
      0.378942
      0.359409
    
    
      442
      RRBS_trito_pool_2_CGTACTAG.TAGCGG
      0.567804
      0.392930
      0.650606
      0.371967
      CLL
      CLL
      trito_pool_2
      0.0
      0.542448
      0.379673
      0.565934
      0.141666
      0.161357
      0.190254
      0.0
      0.190254
      0.322077
      0.564060
      0.661459
      0.291782
      0.141023
      0.236705
      0.775427
      0.812801
      0.584395
      0.788413
      0.0
      0.373111
      0.419487
      0.363822
      0.398524
      0.443218
      0.429929
      0.0
      0.429929
      0.428916
      0.508213
      0.389595
      0.371629
      0.425177
      0.379944
      0.390322
      0.401379
      0.390136
      0.365038
    
    
      443
      RRBS_trito_pool_2_CGTACTAG.TATCTC
      0.599881
      0.371286
      0.647639
      0.360518
      CLL
      CLL
      trito_pool_2
      0.0
      0.575018
      0.407772
      0.599556
      0.150032
      0.172842
      0.207183
      0.0
      0.207183
      0.348191
      0.524038
      0.668196
      0.314785
      0.147052
      0.263346
      0.860790
      0.826304
      0.608059
      0.807089
      0.0
      0.350740
      0.387199
      0.345054
      0.369375
      0.416003
      0.412018
      0.0
      0.412018
      0.418236
      0.488627
      0.380793
      0.343215
      0.395603
      0.371997
      0.304058
      0.381193
      0.377228
      0.343486
    
    
      444
      RRBS_trito_pool_2_CGTACTAG.TCTCTG
      0.597122
      0.387602
      0.651297
      0.369044
      CLL
      CLL
      trito_pool_2
      0.0
      0.574766
      0.414443
      0.597902
      0.153941
      0.177219
      0.200535
      0.0
      0.200535
      0.344312
      0.593102
      0.687200
      0.318141
      0.152659
      0.260521
      0.857143
      0.820577
      0.596070
      0.810128
      0.0
      0.364954
      0.410597
      0.357541
      0.390213
      0.434403
      0.418302
      0.0
      0.418302
      0.436308
      0.430239
      0.403836
      0.358261
      0.411722
      0.383838
      0.307817
      0.397070
      0.395306
      0.363937
    
    
      445
      RRBS_trito_pool_2_CGTACTAG.TGACAG
      0.588475
      0.377043
      0.654169
      0.362253
      CLL
      CLL
      trito_pool_2
      0.0
      0.566762
      0.398915
      0.590485
      0.146940
      0.169929
      0.200901
      0.0
      0.200901
      0.330337
      0.614493
      0.668077
      0.309691
      0.140807
      0.241382
      0.877043
      0.819644
      0.588788
      0.797851
      0.0
      0.352289
      0.386013
      0.345792
      0.381209
      0.425696
      0.436417
      0.0
      0.436417
      0.417572
      0.441868
      0.379378
      0.356776
      0.394481
      0.368598
      0.322557
      0.387040
      0.387626
      0.360044
    
  

446 rows × 46 columns







    



In [47] used 0.281 MiB RAM in 0.306s, peaked 0.000 MiB above current, total RAM usage 110.535 MiB



In [48]:

    
merged.to_csv("total_genomic_region.csv", index=False)









    



In [48] used 1.469 MiB RAM in 0.095s, peaked 0.000 MiB above current, total RAM usage 112.004 MiB



In [49]:

    
merged.shape









    Out[49]:





(446, 46)






    



In [49] used 0.000 MiB RAM in 0.003s, peaked 0.000 MiB above current, total RAM usage 112.004 MiB



In [50]:

    
merged.columns









    Out[50]:





Index(['filename', 'methylation', 'PDR_total', 'methylation_unweighted',
       'PDR_unweighted', 'type', 'bio', 'protocol', 'methylation_tssDistance',
       'methylation_genesDistance', 'methylation_exonsDistance',
       'methylation_intronsDistance', 'methylation_promoterDistance',
       'methylation_cgiDistance', 'methylation_ctcfDistance',
       'methylation_ctcfUpDistance', 'methylation_ctcfDownDistance',
       'methylation_geneDistalRegulatoryModulesDistance',
       'methylation_vistaEnhancersDistance', 'methylation_3PrimeUTRDistance',
       'methylation_5PrimeUTRDistance', 'methylation_firstExonDistance',
       'methylation_geneDistalRegulatoryModulesK562Distance',
       'methylation_hypoInHues64Distance', 'methylation_intergenic',
       'methylation_shore', 'methylation_shelf', 'PDR_tssDistance',
       'PDR_genesDistance', 'PDR_exonsDistance', 'PDR_intronsDistance',
       'PDR_promoterDistance', 'PDR_cgiDistance', 'PDR_ctcfDistance',
       'PDR_ctcfUpDistance', 'PDR_ctcfDownDistance',
       'PDR_geneDistalRegulatoryModulesDistance', 'PDR_vistaEnhancersDistance',
       'PDR_3PrimeUTRDistance', 'PDR_5PrimeUTRDistance',
       'PDR_firstExonDistance', 'PDR_geneDistalRegulatoryModulesK562Distance',
       'PDR_hypoInHues64Distance', 'PDR_intergenic', 'PDR_shore', 'PDR_shelf'],
      dtype='object')






    



In [50] used 0.000 MiB RAM in 0.006s, peaked 0.000 MiB above current, total RAM usage 112.004 MiB



In [51]:

    
#
# First do pairs by CLL vs Normal B;    We could discuss protocols at a later point
#
normal = merged[merged["type"]=="normal"]
CLL = merged[merged["type"]=="CLL"]









    



In [51] used 0.000 MiB RAM in 0.005s, peaked 0.000 MiB above current, total RAM usage 112.004 MiB



In [53]:

    
print(len(normal))
print(len(CLL))









    



342
104
In [53] used 0.000 MiB RAM in 0.002s, peaked 0.000 MiB above current, total RAM usage 112.004 MiB



In [54]:

    
CLL_pairs = CLL
normal_pairs = normal









    



In [54] used 0.000 MiB RAM in 0.001s, peaked 0.000 MiB above current, total RAM usage 112.004 MiB



In [58]:

    
CLL_pairs.columns









    Out[58]:





Index(['filename', 'methylation', 'PDR_total', 'methylation_unweighted',
       'PDR_unweighted', 'type', 'bio', 'protocol', 'methylation_tssDistance',
       'methylation_genesDistance', 'methylation_exonsDistance',
       'methylation_intronsDistance', 'methylation_promoterDistance',
       'methylation_cgiDistance', 'methylation_ctcfDistance',
       'methylation_ctcfUpDistance', 'methylation_ctcfDownDistance',
       'methylation_geneDistalRegulatoryModulesDistance',
       'methylation_vistaEnhancersDistance', 'methylation_3PrimeUTRDistance',
       'methylation_5PrimeUTRDistance', 'methylation_firstExonDistance',
       'methylation_geneDistalRegulatoryModulesK562Distance',
       'methylation_hypoInHues64Distance', 'methylation_intergenic',
       'methylation_shore', 'methylation_shelf', 'PDR_tssDistance',
       'PDR_genesDistance', 'PDR_exonsDistance', 'PDR_intronsDistance',
       'PDR_promoterDistance', 'PDR_cgiDistance', 'PDR_ctcfDistance',
       'PDR_ctcfUpDistance', 'PDR_ctcfDownDistance',
       'PDR_geneDistalRegulatoryModulesDistance', 'PDR_vistaEnhancersDistance',
       'PDR_3PrimeUTRDistance', 'PDR_5PrimeUTRDistance',
       'PDR_firstExonDistance', 'PDR_geneDistalRegulatoryModulesK562Distance',
       'PDR_hypoInHues64Distance', 'PDR_intergenic', 'PDR_shore', 'PDR_shelf'],
      dtype='object')






    



In [58] used 0.012 MiB RAM in 0.005s, peaked 0.000 MiB above current, total RAM usage 149.809 MiB



In [80]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation, CLL_pairs.methylation)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_difference': stacked})[['filename', 'methylation_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs1 = pd.merge(out, methylation_differences, how='inner')
print(pairs1.shape)









    



(5356, 44)
In [80] used 3.605 MiB RAM in 14.733s, peaked 0.000 MiB above current, total RAM usage 178.270 MiB



In [81]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_total, CLL_pairs.PDR_total)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
PDR_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_difference': stacked})[['filename', 'PDR_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs2 = pd.merge(out, PDR_differences, how='inner')
print(pairs2.shape)









    



(5356, 44)
In [81] used 2.234 MiB RAM in 15.129s, peaked 0.000 MiB above current, total RAM usage 180.504 MiB



In [82]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_unweighted, CLL_pairs.methylation_unweighted)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_unweighted_difference': stacked})[['filename', 'methylation_unweighted_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs3 = pd.merge(out, methylation_differences, how='inner')
print(pairs3.shape)









    



(5356, 44)
In [82] used 3.953 MiB RAM in 14.488s, peaked 0.000 MiB above current, total RAM usage 184.457 MiB



In [83]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_unweighted, CLL_pairs.PDR_unweighted)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
PDR_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_unweighted_difference': stacked})[['filename', 'PDR_unweighted_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs4 = pd.merge(out, PDR_differences, how='inner')
print(pairs4.shape)









    



(5356, 44)
In [83] used 1.730 MiB RAM in 14.159s, peaked 0.000 MiB above current, total RAM usage 186.188 MiB



In [84]:

    
"""
  'methylation_tssDistance',
       'methylation_genesDistance', 'methylation_exonsDistance',
       'methylation_intronsDistance', 'methylation_promoterDistance',
       'methylation_cgiDistance', 'methylation_ctcfDistance',
       'methylation_ctcfUpDistance', 'methylation_ctcfDownDistance',
       'methylation_geneDistalRegulatoryModulesDistance',
       'methylation_vistaEnhancersDistance', 'methylation_3PrimeUTRDistance',
       'methylation_5PrimeUTRDistance', 'methylation_firstExonDistance',
       'methylation_geneDistalRegulatoryModulesK562Distance',
       'methylation_hypoInHues64Distance', 'methylation_intergenic',
       'methylation_shore', 'methylation_shelf'

"""









    Out[84]:





"\n  'methylation_tssDistance',\n       'methylation_genesDistance', 'methylation_exonsDistance',\n       'methylation_intronsDistance', 'methylation_promoterDistance',\n       'methylation_cgiDistance', 'methylation_ctcfDistance',\n       'methylation_ctcfUpDistance', 'methylation_ctcfDownDistance',\n       'methylation_geneDistalRegulatoryModulesDistance',\n       'methylation_vistaEnhancersDistance', 'methylation_3PrimeUTRDistance',\n       'methylation_5PrimeUTRDistance', 'methylation_firstExonDistance',\n       'methylation_geneDistalRegulatoryModulesK562Distance',\n       'methylation_hypoInHues64Distance', 'methylation_intergenic',\n       'methylation_shore', 'methylation_shelf'\n\n"






    



In [84] used 0.016 MiB RAM in 0.006s, peaked 0.000 MiB above current, total RAM usage 186.203 MiB



In [85]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_tssDistance, CLL_pairs.methylation_tssDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_tssDistance_difference': stacked})[['filename', 'methylation_tssDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs5 = pd.merge(out, methylation_differences, how='inner')
print(pairs5.shape)









    



(5356, 44)
In [85] used 0.016 MiB RAM in 15.618s, peaked 0.000 MiB above current, total RAM usage 186.219 MiB



In [86]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_genesDistance, CLL_pairs.methylation_genesDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_genesDistance_difference': stacked})[['filename', 'methylation_genesDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs6 = pd.merge(out, methylation_differences, how='inner')
print(pairs6.shape)









    



(5356, 44)
In [86] used 2.703 MiB RAM in 15.963s, peaked 0.000 MiB above current, total RAM usage 188.922 MiB



In [87]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_exonsDistance, CLL_pairs.methylation_exonsDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_exonsDistance_difference': stacked})[['filename', 'methylation_exonsDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs7 = pd.merge(out, methylation_differences, how='inner')
print(pairs7.shape)









    



(5356, 44)
In [87] used 2.430 MiB RAM in 14.548s, peaked 0.000 MiB above current, total RAM usage 191.352 MiB



In [88]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_intronsDistance, CLL_pairs.methylation_intronsDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_intronsDistance_difference': stacked})[['filename', 'methylation_intronsDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs8 = pd.merge(out, methylation_differences, how='inner')
print(pairs8.shape)









    



(5356, 44)
In [88] used 2.504 MiB RAM in 14.440s, peaked 0.000 MiB above current, total RAM usage 193.855 MiB



In [89]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_promoterDistance, CLL_pairs.methylation_promoterDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_promoterDistance_difference': stacked})[['filename', 'methylation_promoterDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs9 = pd.merge(out, methylation_differences, how='inner')
print(pairs9.shape)









    



(5356, 44)
In [89] used 2.066 MiB RAM in 14.449s, peaked 0.000 MiB above current, total RAM usage 195.922 MiB



In [90]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_cgiDistance, CLL_pairs.methylation_cgiDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_cgiDistance_difference': stacked})[['filename', 'methylation_cgiDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs10 = pd.merge(out, methylation_differences, how='inner')
print(pairs10.shape)









    



(5356, 44)
In [90] used 1.984 MiB RAM in 14.396s, peaked 0.000 MiB above current, total RAM usage 197.906 MiB



In [91]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_ctcfDistance, CLL_pairs.methylation_ctcfDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_ctcfDistance_difference': stacked})[['filename', 'methylation_ctcfDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs11 = pd.merge(out, methylation_differences, how='inner')
print(pairs11.shape)









    



(5356, 44)
In [91] used 0.766 MiB RAM in 14.460s, peaked 0.332 MiB above current, total RAM usage 198.672 MiB



In [92]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_ctcfUpDistance, CLL_pairs.methylation_ctcfUpDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_ctcfUpDistance_difference': stacked})[['filename', 'methylation_ctcfUpDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs12 = pd.merge(out, methylation_differences, how='inner')
print(pairs12.shape)









    



(5356, 44)
In [92] used 1.820 MiB RAM in 15.949s, peaked 0.000 MiB above current, total RAM usage 200.492 MiB



In [93]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_ctcfDownDistance, CLL_pairs.methylation_ctcfDownDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_ctcfDownDistance_difference': stacked})[['filename', 'methylation_ctcfDownDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs13 = pd.merge(out, methylation_differences, how='inner')
print(pairs13.shape)









    



(5356, 44)
In [93] used 2.316 MiB RAM in 15.657s, peaked 0.000 MiB above current, total RAM usage 202.809 MiB



In [94]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_geneDistalRegulatoryModulesDistance, CLL_pairs.methylation_geneDistalRegulatoryModulesDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_geneDistalRegulatoryModulesDistance_difference': stacked})[['filename', 'methylation_geneDistalRegulatoryModulesDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs14 = pd.merge(out, methylation_differences, how='inner')
print(pairs14.shape)









    



(5356, 44)
In [94] used 1.984 MiB RAM in 15.914s, peaked 0.000 MiB above current, total RAM usage 204.793 MiB



In [95]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_vistaEnhancersDistance, CLL_pairs.methylation_vistaEnhancersDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_vistaEnhancersDistance_difference': stacked})[['filename', 'methylation_vistaEnhancersDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs15 = pd.merge(out, methylation_differences, how='inner')
print(pairs15.shape)









    



(5356, 44)
In [95] used 2.051 MiB RAM in 15.193s, peaked 0.000 MiB above current, total RAM usage 206.844 MiB



In [96]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_3PrimeUTRDistance, CLL_pairs.methylation_3PrimeUTRDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_3PrimeUTRDistance_difference': stacked})[['filename', 'methylation_3PrimeUTRDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs16 = pd.merge(out, methylation_differences, how='inner')
print(pairs16.shape)









    



(5356, 44)
In [96] used 2.930 MiB RAM in 14.938s, peaked 0.000 MiB above current, total RAM usage 209.773 MiB



In [97]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_5PrimeUTRDistance, CLL_pairs.methylation_5PrimeUTRDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_5PrimeUTRDistance_difference': stacked})[['filename', 'methylation_5PrimeUTRDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs17 = pd.merge(out, methylation_differences, how='inner')
print(pairs17.shape)









    



(5356, 44)
In [97] used 2.066 MiB RAM in 15.019s, peaked 0.000 MiB above current, total RAM usage 211.840 MiB



In [98]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_firstExonDistance, CLL_pairs.methylation_firstExonDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_firstExonDistance_difference': stacked})[['filename', 'methylation_firstExonDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs18 = pd.merge(out, methylation_differences, how='inner')
print(pairs18.shape)









    



(5356, 44)
In [98] used 2.316 MiB RAM in 15.135s, peaked 0.000 MiB above current, total RAM usage 214.156 MiB



In [99]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_geneDistalRegulatoryModulesK562Distance, CLL_pairs.methylation_geneDistalRegulatoryModulesK562Distance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_geneDistalRegulatoryModulesK562Distance_difference': stacked})[['filename', 'methylation_geneDistalRegulatoryModulesK562Distance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs19 = pd.merge(out, methylation_differences, how='inner')
print(pairs19.shape)









    



(5356, 44)
In [99] used 3.656 MiB RAM in 16.087s, peaked 0.000 MiB above current, total RAM usage 217.812 MiB



In [100]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_hypoInHues64Distance, CLL_pairs.methylation_hypoInHues64Distance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_hypoInHues64Distance_difference': stacked})[['filename', 'methylation_hypoInHues64Distance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs20 = pd.merge(out, methylation_differences, how='inner')
print(pairs20.shape)









    



(5356, 44)
In [100] used 2.152 MiB RAM in 14.291s, peaked 0.000 MiB above current, total RAM usage 219.965 MiB



In [101]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_intergenic, CLL_pairs.methylation_intergenic)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_intergenic_difference': stacked})[['filename', 'methylation_intergenic_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs21 = pd.merge(out, methylation_differences, how='inner')
print(pairs21.shape)









    



(5356, 44)
In [101] used 2.242 MiB RAM in 15.156s, peaked 0.000 MiB above current, total RAM usage 222.207 MiB



In [102]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_shore, CLL_pairs.methylation_shore)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_shore_difference': stacked})[['filename', 'methylation_shore_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs22 = pd.merge(out, methylation_differences, how='inner')
print(pairs22.shape)









    



(5356, 44)
In [102] used 2.191 MiB RAM in 14.919s, peaked 0.000 MiB above current, total RAM usage 224.398 MiB



In [103]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.methylation_shelf, CLL_pairs.methylation_shelf)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'methylation_shelf_difference': stacked})[['filename', 'methylation_shelf_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs23 = pd.merge(out, methylation_differences, how='inner')
print(pairs23.shape)









    



(5356, 44)
In [103] used 2.320 MiB RAM in 16.496s, peaked 0.000 MiB above current, total RAM usage 226.719 MiB



In [ ]:



In [105]:

    
"""
###
PDR by genomic regions
###
"""









    Out[105]:





'\n###\nPDR by genomic regions\n###\n'






    



In [105] used 0.000 MiB RAM in 0.002s, peaked 0.000 MiB above current, total RAM usage 226.129 MiB



In [106]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_tssDistance, CLL_pairs.PDR_tssDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_tssDistance_difference': stacked})[['filename', 'PDR_tssDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs24 = pd.merge(out, methylation_differences, how='inner')
print(pairs24.shape)









    



(5356, 44)
In [106] used 2.242 MiB RAM in 17.194s, peaked 0.000 MiB above current, total RAM usage 228.371 MiB



In [107]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_genesDistance, CLL_pairs.PDR_genesDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_genesDistance_difference': stacked})[['filename', 'PDR_genesDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs25 = pd.merge(out, methylation_differences, how='inner')
print(pairs25.shape)









    



(5356, 44)
In [107] used 2.273 MiB RAM in 16.817s, peaked 0.000 MiB above current, total RAM usage 230.645 MiB



In [108]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_exonsDistance, CLL_pairs.PDR_exonsDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_exonsDistance_difference': stacked})[['filename', 'PDR_exonsDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs26 = pd.merge(out, methylation_differences, how='inner')
print(pairs26.shape)









    



(5356, 44)
In [108] used 2.398 MiB RAM in 17.337s, peaked 0.000 MiB above current, total RAM usage 233.043 MiB



In [109]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_intronsDistance, CLL_pairs.PDR_intronsDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_intronsDistance_difference': stacked})[['filename', 'PDR_intronsDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs27 = pd.merge(out, methylation_differences, how='inner')
print(pairs27.shape)









    



(5356, 44)
In [109] used 0.430 MiB RAM in 15.936s, peaked 0.000 MiB above current, total RAM usage 233.473 MiB



In [110]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_promoterDistance, CLL_pairs.PDR_promoterDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_promoterDistance_difference': stacked})[['filename', 'PDR_promoterDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs28 = pd.merge(out, methylation_differences, how='inner')
print(pairs28.shape)









    



(5356, 44)
In [110] used 2.398 MiB RAM in 16.367s, peaked 0.000 MiB above current, total RAM usage 235.871 MiB



In [111]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_cgiDistance, CLL_pairs.PDR_cgiDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_cgiDistance_difference': stacked})[['filename', 'PDR_cgiDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs29 = pd.merge(out, methylation_differences, how='inner')
print(pairs29.shape)









    



(5356, 44)
In [111] used 1.969 MiB RAM in 19.534s, peaked 0.000 MiB above current, total RAM usage 237.840 MiB



In [112]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_ctcfDistance, CLL_pairs.PDR_ctcfDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_ctcfDistance_difference': stacked})[['filename', 'PDR_ctcfDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs30 = pd.merge(out, methylation_differences, how='inner')
print(pairs30.shape)









    



(5356, 44)
In [112] used 2.465 MiB RAM in 17.458s, peaked 0.000 MiB above current, total RAM usage 240.305 MiB



In [113]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_ctcfUpDistance, CLL_pairs.PDR_ctcfUpDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_ctcfUpDistance_difference': stacked})[['filename', 'PDR_ctcfUpDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs31 = pd.merge(out, methylation_differences, how='inner')
print(pairs31.shape)









    



(5356, 44)
In [113] used 2.234 MiB RAM in 16.812s, peaked 0.000 MiB above current, total RAM usage 242.539 MiB



In [114]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_ctcfDownDistance, CLL_pairs.PDR_ctcfDownDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_ctcfDownDistance_difference': stacked})[['filename', 'PDR_ctcfDownDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs32 = pd.merge(out, methylation_differences, how='inner')
print(pairs32.shape)









    



(5356, 44)
In [114] used 1.984 MiB RAM in 19.603s, peaked 0.000 MiB above current, total RAM usage 244.523 MiB



In [115]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_geneDistalRegulatoryModulesDistance, CLL_pairs.PDR_geneDistalRegulatoryModulesDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_geneDistalRegulatoryModulesDistance_difference': stacked})[['filename', 'PDR_geneDistalRegulatoryModulesDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs33 = pd.merge(out, methylation_differences, how='inner')
print(pairs33.shape)









    



(5356, 44)
In [115] used 2.566 MiB RAM in 18.701s, peaked 0.000 MiB above current, total RAM usage 247.090 MiB



In [116]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_vistaEnhancersDistance, CLL_pairs.PDR_vistaEnhancersDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_vistaEnhancersDistance_difference': stacked})[['filename', 'PDR_vistaEnhancersDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs34 = pd.merge(out, methylation_differences, how='inner')
print(pairs34.shape)









    



(5356, 44)
In [116] used 2.234 MiB RAM in 17.241s, peaked 0.000 MiB above current, total RAM usage 249.324 MiB



In [117]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_3PrimeUTRDistance, CLL_pairs.PDR_3PrimeUTRDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_3PrimeUTRDistance_difference': stacked})[['filename', 'PDR_3PrimeUTRDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs35 = pd.merge(out, methylation_differences, how='inner')
print(pairs35.shape)









    



(5356, 44)
In [117] used 3.953 MiB RAM in 14.677s, peaked 0.000 MiB above current, total RAM usage 253.277 MiB



In [118]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_5PrimeUTRDistance, CLL_pairs.PDR_5PrimeUTRDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_5PrimeUTRDistance_difference': stacked})[['filename', 'PDR_5PrimeUTRDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs36 = pd.merge(out, methylation_differences, how='inner')
print(pairs36.shape)









    



(5356, 44)
In [118] used 1.824 MiB RAM in 14.132s, peaked 0.000 MiB above current, total RAM usage 255.102 MiB



In [119]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_firstExonDistance, CLL_pairs.PDR_firstExonDistance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_firstExonDistance_difference': stacked})[['filename', 'PDR_firstExonDistance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs37 = pd.merge(out, methylation_differences, how='inner')
print(pairs37.shape)









    



(5356, 44)
In [119] used 2.316 MiB RAM in 14.119s, peaked 0.000 MiB above current, total RAM usage 257.418 MiB



In [120]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_geneDistalRegulatoryModulesK562Distance, CLL_pairs.PDR_geneDistalRegulatoryModulesK562Distance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_geneDistalRegulatoryModulesK562Distance_difference': stacked})[['filename', 'PDR_geneDistalRegulatoryModulesK562Distance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs38 = pd.merge(out, methylation_differences, how='inner')
print(pairs38.shape)









    



(5356, 44)
In [120] used 2.148 MiB RAM in 15.021s, peaked 0.000 MiB above current, total RAM usage 259.566 MiB



In [121]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_hypoInHues64Distance, CLL_pairs.PDR_hypoInHues64Distance)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_hypoInHues64Distance_difference': stacked})[['filename', 'PDR_hypoInHues64Distance_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs39 = pd.merge(out, methylation_differences, how='inner')
print(pairs39.shape)









    



(5356, 44)
In [121] used 1.902 MiB RAM in 14.078s, peaked 0.000 MiB above current, total RAM usage 261.469 MiB



In [122]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_intergenic, CLL_pairs.PDR_intergenic)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_intergenic_difference': stacked})[['filename', 'PDR_intergenic_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs40 = pd.merge(out, methylation_differences, how='inner')
print(pairs40.shape)









    



(5356, 44)
In [122] used 2.234 MiB RAM in 16.987s, peaked 0.000 MiB above current, total RAM usage 263.703 MiB



In [123]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_shore, CLL_pairs.PDR_shore)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_shore_difference': stacked})[['filename', 'PDR_shore_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs41 = pd.merge(out, methylation_differences, how='inner')
print(pairs41.shape)









    



(5356, 44)
In [123] used 1.984 MiB RAM in 19.821s, peaked 0.000 MiB above current, total RAM usage 265.688 MiB



In [124]:

    
CLL_pairsA = CLL_pairs.set_index("filename")
from itertools import combinations
cc = list(combinations(CLL_pairs.filename, 2)) # combines into all pairs
out = pd.DataFrame([CLL_pairsA.loc[c,:].mean() for c in cc], index=cc)  # covariates between pairs == mean
df_ex = pd.DataFrame(np.abs(np.subtract.outer(CLL_pairs.PDR_shelf, CLL_pairs.PDR_shelf)), CLL_pairs.filename, CLL_pairs.filename)
stacked = df_ex.stack()
methylation_differences = pd.DataFrame({'filename': stacked.index.to_series(), 'PDR_shelf_difference': stacked})[['filename', 'PDR_shelf_difference']].reset_index(drop=True)
out['filename'] = out.index
out = out.reset_index(drop=True)
pairs42 = pd.merge(out, methylation_differences, how='inner')
print(pairs42.shape)









    



(5356, 44)
In [124] used 2.234 MiB RAM in 16.024s, peaked 0.000 MiB above current, total RAM usage 267.922 MiB



In [ ]:



In [125]:

    
pairs42









    Out[125]:






  
    
      
      methylation
      PDR_total
      methylation_unweighted
      PDR_unweighted
      methylation_tssDistance
      methylation_genesDistance
      methylation_exonsDistance
      methylation_intronsDistance
      methylation_promoterDistance
      methylation_cgiDistance
      methylation_ctcfDistance
      methylation_ctcfUpDistance
      methylation_ctcfDownDistance
      methylation_geneDistalRegulatoryModulesDistance
      methylation_vistaEnhancersDistance
      methylation_3PrimeUTRDistance
      methylation_5PrimeUTRDistance
      methylation_firstExonDistance
      methylation_geneDistalRegulatoryModulesK562Distance
      methylation_hypoInHues64Distance
      methylation_intergenic
      methylation_shore
      methylation_shelf
      PDR_tssDistance
      PDR_genesDistance
      PDR_exonsDistance
      PDR_intronsDistance
      PDR_promoterDistance
      PDR_cgiDistance
      PDR_ctcfDistance
      PDR_ctcfUpDistance
      PDR_ctcfDownDistance
      PDR_geneDistalRegulatoryModulesDistance
      PDR_vistaEnhancersDistance
      PDR_3PrimeUTRDistance
      PDR_5PrimeUTRDistance
      PDR_firstExonDistance
      PDR_geneDistalRegulatoryModulesK562Distance
      PDR_hypoInHues64Distance
      PDR_intergenic
      PDR_shore
      PDR_shelf
      filename
      PDR_shelf_difference
    
  
  
    
      0
      0.551295
      0.397926
      0.626034
      0.370854
      0.0
      0.526491
      0.356053
      0.552839
      0.144775
      0.165605
      0.186561
      0.0
      0.186561
      0.313298
      0.450917
      0.623572
      0.281453
      0.140055
      0.241887
      0.748198
      0.808540
      0.560646
      0.793948
      0.0
      0.379121
      0.427961
      0.371383
      0.413445
      0.454698
      0.439447
      0.0
      0.439447
      0.443367
      0.617032
      0.392821
      0.381384
      0.442329
      0.391547
      0.371952
      0.399228
      0.391493
      0.353839
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.017234
    
    
      1
      0.561168
      0.395660
      0.632905
      0.371997
      0.0
      0.538927
      0.372424
      0.564144
      0.143587
      0.167704
      0.199828
      0.0
      0.199828
      0.322613
      0.498961
      0.657855
      0.288344
      0.140775
      0.236259
      0.783529
      0.806741
      0.571259
      0.796352
      0.0
      0.377060
      0.425335
      0.367250
      0.409391
      0.453187
      0.444993
      0.0
      0.444993
      0.448398
      0.359164
      0.426179
      0.381641
      0.439329
      0.401194
      0.338826
      0.395636
      0.383800
      0.354399
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.018353
    
    
      2
      0.586573
      0.383793
      0.649101
      0.363193
      0.0
      0.563676
      0.393126
      0.589529
      0.153506
      0.176220
      0.197228
      0.0
      0.197228
      0.335660
      0.571508
      0.662528
      0.305788
      0.148918
      0.247356
      0.836527
      0.825884
      0.600020
      0.809709
      0.0
      0.366661
      0.418496
      0.356945
      0.414704
      0.452944
      0.437487
      0.0
      0.437487
      0.449179
      0.435398
      0.393152
      0.379366
      0.444245
      0.394349
      0.284400
      0.374797
      0.382018
      0.345564
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.000683
    
    
      3
      0.580396
      0.385693
      0.644074
      0.363936
      0.0
      0.555869
      0.388916
      0.579945
      0.148965
      0.173668
      0.196107
      0.0
      0.196107
      0.334811
      0.514905
      0.655823
      0.296143
      0.144047
      0.248409
      0.850315
      0.822764
      0.591608
      0.807360
      0.0
      0.367904
      0.417351
      0.358361
      0.407637
      0.449419
      0.435152
      0.0
      0.435152
      0.437409
      0.400163
      0.403501
      0.376191
      0.432096
      0.386120
      0.336083
      0.381035
      0.378476
      0.345977
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.001510
    
    
      4
      0.565347
      0.386762
      0.641001
      0.362010
      0.0
      0.542164
      0.376641
      0.568011
      0.142906
      0.164885
      0.192264
      0.0
      0.192264
      0.315714
      0.475214
      0.651849
      0.286462
      0.140486
      0.231512
      0.831779
      0.816135
      0.583955
      0.794591
      0.0
      0.369056
      0.416448
      0.359475
      0.405798
      0.445169
      0.430005
      0.0
      0.430005
      0.437915
      0.342854
      0.394958
      0.375891
      0.433419
      0.379527
      0.359972
      0.384842
      0.379762
      0.348089
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.005733
    
    
      5
      0.583745
      0.388191
      0.648812
      0.366751
      0.0
      0.561490
      0.393073
      0.586520
      0.151211
      0.176944
      0.202230
      0.0
      0.202230
      0.339140
      0.528837
      0.664487
      0.304993
      0.145939
      0.252372
      0.812901
      0.820019
      0.593443
      0.805641
      0.0
      0.369654
      0.419303
      0.360364
      0.412780
      0.454607
      0.442732
      0.0
      0.442732
      0.444900
      0.416998
      0.388882
      0.379385
      0.441311
      0.392011
      0.375738
      0.383585
      0.383928
      0.343012
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.004421
    
    
      6
      0.575364
      0.388562
      0.642310
      0.366305
      0.0
      0.552458
      0.386006
      0.578217
      0.150924
      0.173986
      0.196806
      0.0
      0.196806
      0.326897
      0.566176
      0.665881
      0.297271
      0.150684
      0.243671
      0.815142
      0.819686
      0.589356
      0.802803
      0.0
      0.373075
      0.427406
      0.363035
      0.415715
      0.455041
      0.444185
      0.0
      0.444185
      0.446741
      0.440788
      0.399946
      0.383779
      0.446417
      0.393044
      0.347103
      0.378908
      0.381748
      0.347989
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.005533
    
    
      7
      0.582381
      0.388683
      0.646698
      0.367074
      0.0
      0.558780
      0.393456
      0.583339
      0.150527
      0.175767
      0.204094
      0.0
      0.204094
      0.335604
      0.484967
      0.659229
      0.301772
      0.150516
      0.249021
      0.824676
      0.822305
      0.590635
      0.805443
      0.0
      0.371754
      0.422702
      0.362783
      0.413011
      0.455296
      0.452751
      0.0
      0.452751
      0.448067
      0.372743
      0.403088
      0.382035
      0.441989
      0.395990
      0.358361
      0.382204
      0.384448
      0.352543
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.014641
    
    
      8
      0.567135
      0.395730
      0.637371
      0.371038
      0.0
      0.544832
      0.380601
      0.569006
      0.145946
      0.171282
      0.190641
      0.0
      0.190641
      0.316497
      0.542712
      0.637379
      0.293785
      0.140265
      0.234106
      0.820998
      0.808825
      0.580077
      0.795201
      0.0
      0.377668
      0.426121
      0.368661
      0.413402
      0.455472
      0.451045
      0.0
      0.451045
      0.449853
      0.494214
      0.413741
      0.378131
      0.439004
      0.392492
      0.368676
      0.394071
      0.387644
      0.357420
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.024396
    
    
      9
      0.566839
      0.391394
      0.633777
      0.366020
      0.0
      0.544572
      0.379085
      0.569705
      0.146409
      0.169433
      0.197102
      0.0
      0.197102
      0.319901
      0.579025
      0.641064
      0.295379
      0.149054
      0.237203
      0.824352
      0.813197
      0.575825
      0.793850
      0.0
      0.376125
      0.425598
      0.367472
      0.416301
      0.455418
      0.441600
      0.0
      0.441600
      0.442144
      0.339510
      0.402269
      0.386363
      0.448292
      0.386875
      0.342879
      0.382705
      0.386876
      0.347095
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.003746
    
    
      10
      0.572828
      0.391152
      0.642154
      0.367973
      0.0
      0.549228
      0.382513
      0.573596
      0.147106
      0.171157
      0.195066
      0.0
      0.195066
      0.323383
      0.517167
      0.639984
      0.297912
      0.143004
      0.240815
      0.806413
      0.818149
      0.584713
      0.799527
      0.0
      0.373111
      0.420968
      0.363387
      0.414048
      0.456939
      0.438866
      0.0
      0.438866
      0.441841
      0.490781
      0.398909
      0.382705
      0.438881
      0.391178
      0.377740
      0.384666
      0.384590
      0.348841
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.007237
    
    
      11
      0.570431
      0.394100
      0.640568
      0.368005
      0.0
      0.548445
      0.383462
      0.572895
      0.150021
      0.171691
      0.197512
      0.0
      0.197512
      0.324700
      0.530873
      0.642001
      0.299824
      0.147831
      0.245901
      0.811482
      0.814329
      0.575783
      0.796441
      0.0
      0.376631
      0.431420
      0.366070
      0.420563
      0.462508
      0.460409
      0.0
      0.460409
      0.451409
      0.393751
      0.422416
      0.384087
      0.452035
      0.393007
      0.425199
      0.386985
      0.388808
      0.349917
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.009390
    
    
      12
      0.586555
      0.387184
      0.649357
      0.366469
      0.0
      0.565676
      0.397133
      0.591080
      0.152368
      0.177463
      0.208336
      0.0
      0.208336
      0.339760
      0.498276
      0.676277
      0.307506
      0.146069
      0.256148
      0.805441
      0.819506
      0.595773
      0.806092
      0.0
      0.367493
      0.417118
      0.357402
      0.413121
      0.450975
      0.448832
      0.0
      0.448832
      0.442611
      0.410428
      0.391999
      0.380184
      0.437740
      0.387471
      0.317387
      0.384328
      0.383423
      0.348236
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.006028
    
    
      13
      0.571879
      0.398715
      0.637367
      0.371785
      0.0
      0.548319
      0.380245
      0.574034
      0.149515
      0.171182
      0.199198
      0.0
      0.199198
      0.324016
      0.401829
      0.644951
      0.297459
      0.145199
      0.238716
      0.813369
      0.806891
      0.577883
      0.791293
      0.0
      0.381746
      0.436265
      0.372351
      0.426457
      0.467592
      0.462471
      0.0
      0.462471
      0.453047
      0.304228
      0.431407
      0.392820
      0.454017
      0.395637
      0.476810
      0.391672
      0.388853
      0.352361
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.014278
    
    
      14
      0.574364
      0.390812
      0.638729
      0.369089
      0.0
      0.553203
      0.384591
      0.577964
      0.147751
      0.168572
      0.190728
      0.0
      0.190728
      0.331216
      0.592341
      0.659529
      0.301509
      0.140018
      0.244405
      0.831855
      0.811678
      0.582078
      0.797774
      0.0
      0.369719
      0.417920
      0.361119
      0.408143
      0.450672
      0.435474
      0.0
      0.435474
      0.447435
      0.362022
      0.418218
      0.372678
      0.431081
      0.395873
      0.301459
      0.391714
      0.390792
      0.354544
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.018643
    
    
      15
      0.563025
      0.392571
      0.635052
      0.365296
      0.0
      0.537338
      0.374109
      0.562412
      0.146864
      0.171379
      0.195148
      0.0
      0.195148
      0.318039
      0.507820
      0.652158
      0.286704
      0.143441
      0.235816
      0.862091
      0.814903
      0.570021
      0.790561
      0.0
      0.377474
      0.430295
      0.367318
      0.417978
      0.460599
      0.447405
      0.0
      0.447405
      0.448256
      0.442620
      0.413828
      0.387365
      0.446590
      0.390753
      0.275255
      0.378730
      0.384141
      0.358707
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.026970
    
    
      16
      0.558105
      0.401336
      0.629414
      0.375672
      0.0
      0.536255
      0.371571
      0.561038
      0.142838
      0.167093
      0.188449
      0.0
      0.188449
      0.317543
      0.489753
      0.622220
      0.288219
      0.139591
      0.239610
      0.766199
      0.802490
      0.562680
      0.788462
      0.0
      0.383528
      0.430493
      0.374530
      0.415803
      0.456866
      0.443240
      0.0
      0.443240
      0.455693
      0.410082
      0.408209
      0.386900
      0.442361
      0.401489
      0.379217
      0.401247
      0.394236
      0.359091
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.027737
    
    
      17
      0.589533
      0.384442
      0.648214
      0.365278
      0.0
      0.567071
      0.397548
      0.592438
      0.152635
      0.176725
      0.200567
      0.0
      0.200567
      0.335821
      0.558278
      0.665961
      0.311514
      0.147307
      0.249976
      0.837922
      0.824039
      0.600182
      0.807817
      0.0
      0.366934
      0.418365
      0.357557
      0.413279
      0.452939
      0.437543
      0.0
      0.437543
      0.444521
      0.357537
      0.402062
      0.378518
      0.441674
      0.394321
      0.325255
      0.377396
      0.378557
      0.346325
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.002207
    
    
      18
      0.584829
      0.386122
      0.645871
      0.362919
      0.0
      0.561357
      0.393114
      0.586628
      0.153172
      0.176179
      0.204353
      0.0
      0.204353
      0.336560
      0.549394
      0.670547
      0.306589
      0.149030
      0.251405
      0.834840
      0.824608
      0.596731
      0.807800
      0.0
      0.369391
      0.420641
      0.359994
      0.415739
      0.457035
      0.450444
      0.0
      0.450444
      0.447941
      0.352114
      0.391470
      0.385953
      0.446827
      0.392647
      0.287559
      0.376076
      0.381377
      0.345494
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.000544
    
    
      19
      0.569344
      0.395428
      0.634900
      0.377481
      0.0
      0.545893
      0.380526
      0.571689
      0.144707
      0.166553
      0.187823
      0.0
      0.187823
      0.320157
      0.516365
      0.652378
      0.296744
      0.143074
      0.236713
      0.768369
      0.814746
      0.585734
      0.801079
      0.0
      0.379299
      0.432388
      0.368599
      0.420700
      0.460410
      0.453024
      0.0
      0.453024
      0.449037
      0.522290
      0.419229
      0.390426
      0.455015
      0.393230
      0.387566
      0.387376
      0.387222
      0.356956
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.023467
    
    
      20
      0.532427
      0.400277
      0.608316
      0.375039
      0.0
      0.508848
      0.344650
      0.534670
      0.136203
      0.159195
      0.179771
      0.0
      0.179771
      0.294223
      0.336044
      0.633580
      0.258574
      0.134258
      0.219630
      0.849467
      0.802652
      0.543726
      0.779226
      0.0
      0.381811
      0.429993
      0.372421
      0.415090
      0.455377
      0.437571
      0.0
      0.437571
      0.451545
      0.283441
      0.433468
      0.389132
      0.445993
      0.400376
      0.360881
      0.401288
      0.401163
      0.344121
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.002202
    
    
      21
      0.532230
      0.403112
      0.610903
      0.377874
      0.0
      0.507741
      0.355698
      0.533184
      0.138236
      0.167710
      0.186971
      0.0
      0.186971
      0.308027
      0.471364
      0.621988
      0.258712
      0.134631
      0.224186
      0.890476
      0.806141
      0.553951
      0.779511
      0.0
      0.390140
      0.430686
      0.383338
      0.417405
      0.457783
      0.442420
      0.0
      0.442420
      0.448978
      0.345026
      0.411213
      0.392350
      0.446466
      0.403405
      0.231880
      0.389633
      0.391709
      0.342310
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.005825
    
    
      22
      0.594374
      0.395049
      0.655438
      0.374199
      0.0
      0.573736
      0.405002
      0.598216
      0.158911
      0.182839
      0.201224
      0.0
      0.201224
      0.350799
      0.634227
      0.667989
      0.320649
      0.154182
      0.264668
      0.818538
      0.818372
      0.592535
      0.806155
      0.0
      0.376020
      0.432429
      0.365967
      0.431037
      0.473852
      0.456570
      0.0
      0.456570
      0.456758
      0.263758
      0.407668
      0.386698
      0.456228
      0.407150
      0.317577
      0.386858
      0.387665
      0.346707
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.002969
    
    
      23
      0.564698
      0.400428
      0.633837
      0.376670
      0.0
      0.541999
      0.378636
      0.568568
      0.146165
      0.169332
      0.193734
      0.0
      0.193734
      0.324749
      0.477238
      0.655109
      0.291000
      0.140393
      0.240504
      0.816043
      0.807187
      0.575423
      0.796047
      0.0
      0.380053
      0.434202
      0.368875
      0.427783
      0.465704
      0.467551
      0.0
      0.467551
      0.452715
      0.292837
      0.404489
      0.392381
      0.459191
      0.398842
      0.346153
      0.399896
      0.391161
      0.363957
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.037471
    
    
      24
      0.559202
      0.398322
      0.637497
      0.372609
      0.0
      0.536085
      0.376006
      0.560128
      0.143768
      0.168587
      0.203345
      0.0
      0.203345
      0.316097
      0.483790
      0.650469
      0.288335
      0.140910
      0.236297
      0.865983
      0.809547
      0.566528
      0.792310
      0.0
      0.378806
      0.427979
      0.369818
      0.424106
      0.464195
      0.445216
      0.0
      0.445216
      0.447473
      0.424498
      0.394161
      0.388758
      0.450582
      0.396406
      0.286419
      0.392375
      0.396380
      0.347522
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.004599
    
    
      25
      0.579701
      0.391229
      0.646686
      0.372045
      0.0
      0.557762
      0.392912
      0.582109
      0.150211
      0.174574
      0.197605
      0.0
      0.197605
      0.332346
      0.484299
      0.681663
      0.301759
      0.147482
      0.247505
      0.841507
      0.820166
      0.585983
      0.801525
      0.0
      0.375333
      0.426090
      0.366425
      0.423118
      0.463918
      0.452272
      0.0
      0.452272
      0.455448
      0.562734
      0.405547
      0.389146
      0.453629
      0.400900
      0.421621
      0.379836
      0.379635
      0.344143
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.002158
    
    
      26
      0.579455
      0.393811
      0.645546
      0.374480
      0.0
      0.558045
      0.388241
      0.583680
      0.149822
      0.170872
      0.197980
      0.0
      0.197980
      0.326318
      0.500363
      0.656266
      0.306368
      0.146329
      0.242470
      0.821164
      0.814876
      0.590116
      0.798047
      0.0
      0.374556
      0.426213
      0.364076
      0.419114
      0.458953
      0.456082
      0.0
      0.456082
      0.450773
      0.519483
      0.407983
      0.383316
      0.443942
      0.404958
      0.407448
      0.390763
      0.386732
      0.356864
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.023284
    
    
      27
      0.567381
      0.395007
      0.635819
      0.371447
      0.0
      0.545113
      0.377321
      0.569878
      0.145036
      0.168330
      0.193045
      0.0
      0.193045
      0.322619
      0.500578
      0.650690
      0.289468
      0.140298
      0.241467
      0.821806
      0.812082
      0.578802
      0.794615
      0.0
      0.377992
      0.426348
      0.369121
      0.420506
      0.460840
      0.449413
      0.0
      0.449413
      0.451783
      0.439480
      0.404228
      0.393466
      0.445314
      0.398843
      0.398555
      0.390258
      0.386032
      0.356223
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.022001
    
    
      28
      0.561348
      0.398227
      0.636291
      0.375595
      0.0
      0.537481
      0.368655
      0.563892
      0.144020
      0.166652
      0.188667
      0.0
      0.188667
      0.316822
      0.544610
      0.647264
      0.289621
      0.138206
      0.229463
      0.825901
      0.806857
      0.568495
      0.786405
      0.0
      0.380795
      0.431907
      0.371971
      0.417989
      0.461357
      0.451012
      0.0
      0.451012
      0.450138
      0.459838
      0.422747
      0.386098
      0.446144
      0.391688
      0.318395
      0.392682
      0.392195
      0.344016
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.002413
    
    
      29
      0.579461
      0.395725
      0.646355
      0.376230
      0.0
      0.556855
      0.396536
      0.580833
      0.152036
      0.178565
      0.198986
      0.0
      0.198986
      0.336717
      0.501606
      0.654408
      0.301080
      0.152396
      0.249491
      0.819054
      0.818837
      0.585999
      0.801209
      0.0
      0.378741
      0.428184
      0.370138
      0.423813
      0.465175
      0.462379
      0.0
      0.462379
      0.459329
      0.458150
      0.413899
      0.386857
      0.453231
      0.408654
      0.409612
      0.386064
      0.392521
      0.357648
      (RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACA...
      0.024851
    
    
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
    
    
      5326
      0.596766
      0.381684
      0.653927
      0.363298
      0.0
      0.574537
      0.407185
      0.598535
      0.150284
      0.174322
      0.201379
      0.0
      0.201379
      0.341951
      0.597171
      0.680571
      0.314782
      0.147331
      0.255774
      0.878658
      0.821440
      0.601963
      0.807264
      0.0
      0.357838
      0.399577
      0.350386
      0.384825
      0.428788
      0.416093
      0.0
      0.416093
      0.433422
      0.457541
      0.394881
      0.354717
      0.403558
      0.380525
      0.284117
      0.392191
      0.387496
      0.358077
      (RRBS_trito_pool_2_CGTACTAG.GCATTC, RRBS_trito...
      0.011720
    
    
      5327
      0.592442
      0.376405
      0.655363
      0.359902
      0.0
      0.570535
      0.399421
      0.594827
      0.146783
      0.170677
      0.201562
      0.0
      0.201562
      0.334963
      0.607866
      0.671009
      0.310557
      0.141405
      0.246204
      0.888608
      0.820973
      0.598322
      0.801125
      0.0
      0.351506
      0.387285
      0.344512
      0.380323
      0.424434
      0.425150
      0.0
      0.425150
      0.424054
      0.463356
      0.382653
      0.353974
      0.394938
      0.372905
      0.291487
      0.387177
      0.383656
      0.356130
      (RRBS_trito_pool_2_CGTACTAG.GCATTC, RRBS_trito...
      0.007827
    
    
      5328
      0.583397
      0.388502
      0.649407
      0.366957
      0.0
      0.558135
      0.391450
      0.582353
      0.147699
      0.171788
      0.209431
      0.0
      0.209431
      0.334148
      0.481764
      0.671901
      0.305335
      0.143871
      0.253326
      0.874036
      0.811617
      0.573180
      0.789369
      0.0
      0.367095
      0.413670
      0.359908
      0.390008
      0.437328
      0.443670
      0.0
      0.443670
      0.437493
      0.362906
      0.412073
      0.363198
      0.419156
      0.384055
      0.208321
      0.396863
      0.393298
      0.363785
      (RRBS_trito_pool_2_CGTACTAG.GCTGCC, RRBS_trito...
      0.014345
    
    
      5329
      0.578001
      0.385881
      0.653252
      0.364053
      0.0
      0.553295
      0.383661
      0.578559
      0.146541
      0.168179
      0.203103
      0.0
      0.203103
      0.330876
      0.441302
      0.671057
      0.300918
      0.143190
      0.245404
      0.881851
      0.815285
      0.572946
      0.792663
      0.0
      0.366809
      0.411266
      0.359889
      0.392939
      0.437887
      0.440739
      0.0
      0.440739
      0.432628
      0.414817
      0.394897
      0.367939
      0.415584
      0.385481
      0.224830
      0.390383
      0.398111
      0.357957
      (RRBS_trito_pool_2_CGTACTAG.GCTGCC, RRBS_trito...
      0.002688
    
    
      5330
      0.583919
      0.381640
      0.655076
      0.362032
      0.0
      0.559107
      0.391010
      0.584520
      0.147504
      0.171735
      0.204042
      0.0
      0.204042
      0.334797
      0.498691
      0.671189
      0.305718
      0.143510
      0.249380
      0.891078
      0.816287
      0.580675
      0.790006
      0.0
      0.360926
      0.405322
      0.353275
      0.384534
      0.432656
      0.440986
      0.0
      0.440986
      0.432136
      0.532505
      0.394468
      0.357032
      0.408812
      0.379037
      0.221391
      0.387849
      0.385415
      0.358011
      (RRBS_trito_pool_2_CGTACTAG.GCTGCC, RRBS_trito...
      0.002796
    
    
      5331
      0.575568
      0.388494
      0.650562
      0.366684
      0.0
      0.550137
      0.384495
      0.574614
      0.143898
      0.165840
      0.203452
      0.0
      0.203452
      0.327149
      0.514801
      0.673324
      0.297515
      0.141851
      0.244929
      0.850575
      0.812592
      0.575647
      0.789166
      0.0
      0.368728
      0.415280
      0.360695
      0.392584
      0.439785
      0.442581
      0.0
      0.442581
      0.428255
      0.475101
      0.399813
      0.364332
      0.420080
      0.378762
      0.256228
      0.395741
      0.391012
      0.360825
      (RRBS_trito_pool_2_CGTACTAG.GCTGCC, RRBS_trito...
      0.008425
    
    
      5332
      0.591606
      0.377671
      0.649079
      0.360959
      0.0
      0.566422
      0.398545
      0.591425
      0.148082
      0.171582
      0.211917
      0.0
      0.211917
      0.340206
      0.494790
      0.676692
      0.309016
      0.144866
      0.258249
      0.893256
      0.819344
      0.587478
      0.798504
      0.0
      0.357542
      0.399136
      0.351311
      0.378009
      0.426178
      0.433626
      0.0
      0.433626
      0.422915
      0.465308
      0.395412
      0.350125
      0.405293
      0.374789
      0.213096
      0.385648
      0.384558
      0.350049
      (RRBS_trito_pool_2_CGTACTAG.GCTGCC, RRBS_trito...
      0.013126
    
    
      5333
      0.590227
      0.385830
      0.650908
      0.365222
      0.0
      0.566296
      0.401880
      0.590599
      0.150036
      0.173771
      0.208593
      0.0
      0.208593
      0.338267
      0.529322
      0.686195
      0.310695
      0.147669
      0.256837
      0.891433
      0.816480
      0.581484
      0.800023
      0.0
      0.364649
      0.410835
      0.357554
      0.388428
      0.435377
      0.436768
      0.0
      0.436768
      0.431951
      0.436114
      0.406933
      0.357647
      0.413353
      0.380709
      0.214975
      0.393586
      0.393597
      0.360275
      (RRBS_trito_pool_2_CGTACTAG.GCTGCC, RRBS_trito...
      0.007324
    
    
      5334
      0.585903
      0.380550
      0.652344
      0.361827
      0.0
      0.562295
      0.394116
      0.586890
      0.146536
      0.170126
      0.208776
      0.0
      0.208776
      0.331279
      0.540018
      0.676633
      0.306469
      0.141743
      0.247267
      0.901383
      0.816014
      0.577843
      0.793885
      0.0
      0.358316
      0.398543
      0.351680
      0.383926
      0.431024
      0.445825
      0.0
      0.445825
      0.422583
      0.441928
      0.394705
      0.356905
      0.404732
      0.373089
      0.222345
      0.388572
      0.389757
      0.358328
      (RRBS_trito_pool_2_CGTACTAG.GCTGCC, RRBS_trito...
      0.003431
    
    
      5335
      0.578066
      0.390325
      0.652140
      0.369610
      0.0
      0.553603
      0.385794
      0.577617
      0.148109
      0.169644
      0.195882
      0.0
      0.195882
      0.332803
      0.457524
      0.657769
      0.303005
      0.144382
      0.245578
      0.830164
      0.814519
      0.579229
      0.792113
      0.0
      0.369561
      0.413863
      0.362230
      0.396304
      0.438863
      0.429175
      0.0
      0.429175
      0.442527
      0.335733
      0.396939
      0.374103
      0.419756
      0.391956
      0.311017
      0.397143
      0.399521
      0.365129
      (RRBS_trito_pool_2_CGTACTAG.GGCATC, RRBS_trito...
      0.011657
    
    
      5336
      0.583985
      0.386084
      0.653964
      0.367589
      0.0
      0.559416
      0.393142
      0.583578
      0.149072
      0.173201
      0.196821
      0.0
      0.196821
      0.336724
      0.514912
      0.657901
      0.307806
      0.144702
      0.249554
      0.839391
      0.815520
      0.586957
      0.789456
      0.0
      0.363677
      0.407919
      0.355615
      0.387898
      0.433633
      0.429422
      0.0
      0.429422
      0.442035
      0.453422
      0.396510
      0.363197
      0.412984
      0.385512
      0.307578
      0.394610
      0.386825
      0.365183
      (RRBS_trito_pool_2_CGTACTAG.GGCATC, RRBS_trito...
      0.011549
    
    
      5337
      0.575633
      0.392938
      0.649450
      0.372241
      0.0
      0.550446
      0.386627
      0.573672
      0.145467
      0.167305
      0.196232
      0.0
      0.196232
      0.329076
      0.531023
      0.660036
      0.299602
      0.143043
      0.245102
      0.798888
      0.811826
      0.581929
      0.788616
      0.0
      0.371479
      0.417877
      0.363035
      0.395949
      0.440761
      0.431017
      0.0
      0.431017
      0.438154
      0.396018
      0.401855
      0.370496
      0.424253
      0.385237
      0.342415
      0.402501
      0.392422
      0.367998
      (RRBS_trito_pool_2_CGTACTAG.GGCATC, RRBS_trito...
      0.005920
    
    
      5338
      0.591672
      0.382116
      0.647967
      0.366516
      0.0
      0.566731
      0.400677
      0.590483
      0.149650
      0.173048
      0.204697
      0.0
      0.204697
      0.342133
      0.511011
      0.663404
      0.311103
      0.146058
      0.258423
      0.841569
      0.818577
      0.593761
      0.797954
      0.0
      0.360294
      0.401733
      0.353651
      0.381374
      0.427154
      0.422062
      0.0
      0.422062
      0.432814
      0.386225
      0.397453
      0.356289
      0.409466
      0.381264
      0.299283
      0.392408
      0.385968
      0.357222
      (RRBS_trito_pool_2_CGTACTAG.GGCATC, RRBS_trito...
      0.027471
    
    
      5339
      0.590293
      0.390274
      0.649796
      0.370779
      0.0
      0.566605
      0.404013
      0.589656
      0.151604
      0.175236
      0.201373
      0.0
      0.201373
      0.340194
      0.545544
      0.672907
      0.312782
      0.148861
      0.257011
      0.839746
      0.815714
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      0.417526
      0.387184
      0.301162
      0.400347
      0.395007
      0.367447
      (RRBS_trito_pool_2_CGTACTAG.GGCATC, RRBS_trito...
      0.007021
    
    
      5340
      0.585969
      0.384995
      0.651232
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      0.0
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      0.308532
      0.395332
      0.391167
      0.365501
      (RRBS_trito_pool_2_CGTACTAG.GGCATC, RRBS_trito...
      0.010914
    
    
      5341
      0.578588
      0.383463
      0.657809
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      0.324087
      0.388130
      0.391638
      0.359355
      (RRBS_trito_pool_2_CGTACTAG.GTGAGG, RRBS_trito...
      0.000108
    
    
      5342
      0.570237
      0.390317
      0.653296
      0.369337
      0.0
      0.545606
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      0.569878
      0.144309
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      0.386663
      0.358924
      0.396021
      0.397235
      0.362169
      (RRBS_trito_pool_2_CGTACTAG.GTGAGG, RRBS_trito...
      0.005737
    
    
      5343
      0.586276
      0.379495
      0.651812
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      0.384305
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      0.419131
      0.427949
      0.438135
      0.380278
      0.361030
      0.405894
      0.382689
      0.315792
      0.385928
      0.390781
      0.351394
      (RRBS_trito_pool_2_CGTACTAG.GTGAGG, RRBS_trito...
      0.015815
    
    
      5344
      0.584896
      0.387653
      0.653641
      0.367875
      0.0
      0.561765
      0.396224
      0.585862
      0.150446
      0.171627
      0.195045
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      0.336922
      0.505082
      0.672062
      0.308365
      0.148180
      0.249088
      0.847561
      0.819382
      0.587532
      0.802768
      0.0
      0.367114
      0.411028
      0.359876
      0.394723
      0.436912
      0.422273
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      0.422273
      0.436985
      0.408941
      0.391799
      0.368553
      0.413953
      0.388610
      0.317672
      0.393867
      0.399820
      0.361619
      (RRBS_trito_pool_2_CGTACTAG.GTGAGG, RRBS_trito...
      0.004636
    
    
      5345
      0.580572
      0.382374
      0.655077
      0.364479
      0.0
      0.557763
      0.388460
      0.582154
      0.146946
      0.167982
      0.195228
      0.0
      0.195228
      0.329934
      0.515778
      0.662501
      0.304139
      0.142254
      0.239518
      0.857511
      0.818916
      0.583891
      0.796629
      0.0
      0.360781
      0.398736
      0.354002
      0.390221
      0.432559
      0.431330
      0.0
      0.431330
      0.427617
      0.414756
      0.379571
      0.367810
      0.405332
      0.380990
      0.325042
      0.388852
      0.395980
      0.359672
      (RRBS_trito_pool_2_CGTACTAG.GTGAGG, RRBS_trito...
      0.000743
    
    
      5346
      0.576155
      0.386076
      0.655120
      0.367315
      0.0
      0.551418
      0.386188
      0.575839
      0.145272
      0.167252
      0.190843
      0.0
      0.190843
      0.329725
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      0.659324
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      0.816496
      0.589424
      0.789253
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      0.428334
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      0.428334
      0.432797
      0.565617
      0.384250
      0.364330
      0.413908
      0.380218
      0.355485
      0.393488
      0.384539
      0.362223
      (RRBS_trito_pool_2_CGTACTAG.GTTGAG, RRBS_trito...
      0.005629
    
    
      5347
      0.592194
      0.375254
      0.653636
      0.361591
      0.0
      0.567703
      0.400237
      0.592650
      0.149455
      0.172995
      0.199307
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      0.199307
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      0.422482
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      0.379849
      0.350123
      0.399122
      0.376245
      0.312353
      0.383394
      0.378085
      0.351447
      (RRBS_trito_pool_2_CGTACTAG.GTTGAG, RRBS_trito...
      0.015923
    
    
      5348
      0.590814
      0.383412
      0.655465
      0.365854
      0.0
      0.567577
      0.403573
      0.591823
      0.151409
      0.175183
      0.195984
      0.0
      0.195984
      0.340842
      0.562470
      0.672195
      0.313165
      0.148500
      0.253065
      0.856788
      0.820384
      0.595261
      0.800111
      0.0
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      0.405084
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      0.386318
      0.431682
      0.422521
      0.0
      0.422521
      0.436493
      0.526630
      0.391371
      0.357646
      0.407181
      0.382166
      0.314232
      0.391333
      0.387124
      0.361673
      (RRBS_trito_pool_2_CGTACTAG.GTTGAG, RRBS_trito...
      0.004528
    
    
      5349
      0.586491
      0.378133
      0.656901
      0.362458
      0.0
      0.563575
      0.395809
      0.588115
      0.147909
      0.171538
      0.196167
      0.0
      0.196167
      0.333854
      0.573166
      0.662633
      0.308940
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      0.866738
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      0.591620
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      0.0
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      0.427328
      0.431578
      0.0
      0.431578
      0.427125
      0.532445
      0.379142
      0.356903
      0.398560
      0.374545
      0.321602
      0.386318
      0.383284
      0.359726
      (RRBS_trito_pool_2_CGTACTAG.GTTGAG, RRBS_trito...
      0.000635
    
    
      5350
      0.583842
      0.382108
      0.649122
      0.366242
      0.0
      0.558733
      0.393722
      0.582745
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      0.198718
      0.0
      0.198718
      0.335134
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      0.250026
      0.818109
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      0.385194
      0.357422
      0.410390
      0.375970
      0.347190
      0.391286
      0.383682
      0.354262
      (RRBS_trito_pool_2_CGTACTAG.TAGCGG, RRBS_trito...
      0.021552
    
    
      5351
      0.582463
      0.390266
      0.650951
      0.370506
      0.0
      0.558607
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      0.581918
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      0.195395
      0.0
      0.195395
      0.333195
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      0.364945
      0.418450
      0.381891
      0.349069
      0.399225
      0.392721
      0.364487
      (RRBS_trito_pool_2_CGTACTAG.TAGCGG, RRBS_trito...
      0.001101
    
    
      5352
      0.578139
      0.384987
      0.652388
      0.367110
      0.0
      0.554605
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      0.388881
      0.362541
      (RRBS_trito_pool_2_CGTACTAG.TAGCGG, RRBS_trito...
      0.004994
    
    
      5353
      0.598502
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      0.353712
      (RRBS_trito_pool_2_CGTACTAG.TATCTC, RRBS_trito...
      0.020451
    
    
      5354
      0.594178
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      (RRBS_trito_pool_2_CGTACTAG.TATCTC, RRBS_trito...
      0.016558
    
    
      5355
      0.592798
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      0.391607
      0.357518
      0.403102
      0.376218
      0.315187
      0.392055
      0.391466
      0.361990
      (RRBS_trito_pool_2_CGTACTAG.TCTCTG, RRBS_trito...
      0.003893
    
  

5356 rows × 44 columns







    



In [125] used -0.355 MiB RAM in 0.276s, peaked 0.293 MiB above current, total RAM usage 267.566 MiB



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	filename	methylation_genesDistance	methylation_exonsDistance	methylation_intronsDistance	methylation_promoterDistance	methylation_cgiDistance	methylation_ctcfDistance	methylation_ctcfDownDistance	methylation_geneDistalRegulatoryModulesDistance	methylation_vistaEnhancersDistance	methylation_3PrimeUTRDistance	methylation_5PrimeUTRDistance	methylation_firstExonDistance	methylation_geneDistalRegulatoryModulesK562Distance	methylation_hypoInHues64Distance	methylation_intergenic	methylation_shore	methylation_shelf	PDR_genesDistance	PDR_exonsDistance	PDR_intronsDistance	PDR_promoterDistance	PDR_cgiDistance	PDR_ctcfDistance	PDR_ctcfDownDistance	PDR_geneDistalRegulatoryModulesDistance	PDR_vistaEnhancersDistance	PDR_3PrimeUTRDistance	PDR_5PrimeUTRDistance	PDR_firstExonDistance	PDR_geneDistalRegulatoryModulesK562Distance	PDR_hypoInHues64Distance	PDR_intergenic	PDR_shore	PDR_shelf
0	RRBS_trito_pool_1_TAAGGCGA.ACAACC	0.570721	0.404589	0.594704	0.146371	0.169386	0.199815	0.199815	0.342986	0.444522	0.680480	0.305206	0.145730	0.254209	0.877142	0.820339	0.607671	0.803716	0.343014	0.371890	0.339596	0.347748	0.388709	0.385297	0.385297	0.401254	0.509555	0.386285	0.324236	0.367271	0.354046	0.240359	0.386809	0.377907	0.359143
1	RRBS_trito_pool_1_TAAGGCGA.ACGTGG	0.545781	0.383371	0.568638	0.141545	0.161519	0.191404	0.191404	0.326140	0.589834	0.670559	0.290196	0.140779	0.240221	0.809942	0.816166	0.573089	0.795932	0.348110	0.381251	0.341950	0.349891	0.398898	0.415058	0.415058	0.408417	0.548192	0.382172	0.332749	0.373615	0.359217	0.364148	0.391925	0.386808	0.354120
2	RRBS_trito_pool_1_TAAGGCGA.ACTCAC	0.564547	0.401760	0.588136	0.148529	0.174413	0.209041	0.209041	0.346473	0.553062	0.696068	0.296809	0.148360	0.255392	0.795883	0.832812	0.609544	0.812564	0.338412	0.371890	0.332321	0.351391	0.393829	0.392313	0.392313	0.412311	0.471703	0.378630	0.327488	0.370494	0.338321	0.334783	0.378580	0.378799	0.353949
3	RRBS_trito_pool_1_TAAGGCGA.AGGATG	0.567309	0.399934	0.592890	0.143897	0.168936	0.200661	0.200661	0.342257	0.665920	0.661426	0.308680	0.141673	0.242236	0.787966	0.824659	0.602995	0.799836	0.342724	0.374419	0.337654	0.346109	0.389718	0.399153	0.399153	0.405627	0.359189	0.391002	0.324431	0.360431	0.343730	0.304035	0.380413	0.373345	0.347372
4	RRBS_trito_pool_1_TAAGGCGA.ATAGCG	0.529224	0.367743	0.555131	0.136090	0.156827	0.175426	0.175426	0.307402	0.479145	0.644411	0.273473	0.134137	0.220729	0.815944	0.808981	0.575050	0.788587	0.349254	0.376307	0.342617	0.343348	0.388623	0.403861	0.403861	0.390288	0.471324	0.392438	0.332882	0.358450	0.319824	0.401641	0.398275	0.373236	0.363320

	filename	methylation_genesDistance	methylation_exonsDistance	methylation_intronsDistance	methylation_promoterDistance	methylation_cgiDistance	methylation_ctcfDistance	methylation_ctcfDownDistance	methylation_geneDistalRegulatoryModulesDistance	methylation_vistaEnhancersDistance	methylation_3PrimeUTRDistance	methylation_5PrimeUTRDistance	methylation_firstExonDistance	methylation_geneDistalRegulatoryModulesK562Distance	methylation_hypoInHues64Distance	methylation_intergenic	methylation_shore	methylation_shelf	PDR_genesDistance	PDR_exonsDistance	PDR_intronsDistance	PDR_promoterDistance	PDR_cgiDistance	PDR_ctcfDistance	PDR_ctcfDownDistance	PDR_geneDistalRegulatoryModulesDistance	PDR_vistaEnhancersDistance	PDR_3PrimeUTRDistance	PDR_5PrimeUTRDistance	PDR_firstExonDistance	PDR_geneDistalRegulatoryModulesK562Distance	PDR_hypoInHues64Distance	PDR_intergenic	PDR_shore	PDR_shelf
131	RRBS_normal_B_cell_H1_22_TAGGCATG.GTGAGG	0.476010	0.319477	0.501080	0.112156	0.125920	0.140172	0.140172	0.266191	0.520634	0.568097	0.250866	0.108529	0.199670	0.743346	0.709026	0.512304	0.723009	0.413186	0.417787	0.411922	0.371247	0.397676	0.361732	0.361732	0.449309	0.538398	0.431550	0.378186	0.390782	0.390614	0.433456	0.526395	0.438160	0.468283
132	RRBS_normal_B_cell_H1_22_TAGGCATG.GTTGAG	0.561826	0.421027	0.581238	0.194894	0.241158	0.227289	0.227289	0.355498	0.652030	0.675360	0.320042	0.195983	0.239473	0.848333	0.775009	0.603093	0.765059	0.378380	0.397910	0.375394	0.389046	0.412999	0.390730	0.390730	0.430454	0.628598	0.406830	0.371516	0.395340	0.389081	0.268990	0.455415	0.396795	0.385031
133	RRBS_normal_B_cell_H1_22_TAGGCATG.TAGCGG	0.403834	0.204255	0.435666	0.094118	0.093855	0.072948	0.072948	0.253112	0.333333	0.591837	0.223590	0.096000	0.223404	0.818182	0.820471	0.605528	0.801020	0.320128	0.375319	0.314522	0.375959	0.383838	0.258359	0.258359	0.396266	1.000000	0.346939	0.411282	0.409333	0.386525	0.818182	0.311942	0.381910	0.306122
134	RRBS_normal_B_cell_H1_22_TAGGCATG.TATCTC	0.601704	0.464233	0.621206	0.137723	0.148328	0.140719	0.140719	0.266187	0.400000	0.706186	0.334928	0.135086	0.218656	1.000000	0.878793	0.656104	0.840000	0.286919	0.323835	0.287354	0.384461	0.407314	0.347305	0.347305	0.350719	0.000000	0.368557	0.362440	0.391198	0.270812	0.000000	0.243974	0.306151	0.357500
135	RRBS_normal_B_cell_H1_22_TAGGCATG.TCTCTG	0.560233	0.366567	0.591090	0.120401	0.128137	0.182218	0.182218	0.329330	0.558873	0.703213	0.278496	0.111726	0.241188	0.930269	0.887614	0.628778	0.865630	0.276382	0.338157	0.268336	0.360595	0.380319	0.401676	0.401676	0.369472	0.293523	0.278300	0.314054	0.366833	0.346789	0.255155	0.244022	0.313503	0.248764

	filename	methylation_genesDistance	methylation_exonsDistance	methylation_intronsDistance	methylation_promoterDistance	methylation_cgiDistance	methylation_ctcfDistance	methylation_ctcfDownDistance	methylation_geneDistalRegulatoryModulesDistance	methylation_vistaEnhancersDistance	methylation_3PrimeUTRDistance	methylation_5PrimeUTRDistance	methylation_firstExonDistance	methylation_geneDistalRegulatoryModulesK562Distance	methylation_hypoInHues64Distance	methylation_intergenic	methylation_shore	methylation_shelf	PDR_genesDistance	PDR_exonsDistance	PDR_intronsDistance	PDR_promoterDistance	PDR_cgiDistance	PDR_ctcfDistance	PDR_ctcfDownDistance	PDR_geneDistalRegulatoryModulesDistance	PDR_vistaEnhancersDistance	PDR_3PrimeUTRDistance	PDR_5PrimeUTRDistance	PDR_firstExonDistance	PDR_geneDistalRegulatoryModulesK562Distance	PDR_hypoInHues64Distance	PDR_intergenic	PDR_shore	PDR_shelf	protocol
85	RRBS_NormalBCD19pCD27pcell67_88_GCTACGCT.GTTGAG	0.488591	0.320965	0.515461	0.090361	0.105259	0.121025	0.121025	0.263410	0.516635	0.618186	0.232372	0.087691	0.179349	0.855401	0.786055	0.541282	0.773497	0.281265	0.250894	0.285832	0.152622	0.193308	0.192678	0.192678	0.276641	0.645913	0.369431	0.183830	0.159538	0.183626	0.488850	0.429191	0.356704	0.371891	RRBS_NormalBCD19pCD27pcell67_88
86	RRBS_NormalBCD19pCD27pcell67_88_GCTACGCT.TAGCGG	0.482284	0.313186	0.509034	0.085526	0.094721	0.126048	0.126048	0.258379	0.331160	0.603295	0.229917	0.074569	0.173552	0.891344	0.781317	0.519032	0.765147	0.275113	0.244301	0.281934	0.159508	0.186889	0.213556	0.213556	0.284529	0.364407	0.374666	0.194492	0.150189	0.202991	0.220994	0.416715	0.372722	0.386118	RRBS_NormalBCD19pCD27pcell67_88
87	RRBS_NormalBCD19pCD27pcell67_88_GCTACGCT.TATCTC	0.486434	0.337771	0.509877	0.104169	0.131287	0.145222	0.145222	0.275499	0.528938	0.594743	0.239506	0.108890	0.177779	0.812648	0.734134	0.536591	0.741314	0.317291	0.273234	0.322569	0.168070	0.214958	0.197274	0.197274	0.298599	0.433302	0.385105	0.203708	0.181556	0.193979	0.399823	0.492227	0.388837	0.420926	RRBS_NormalBCD19pCD27pcell67_88
88	RRBS_NormalBCD19pCD27pcell67_88_GCTACGCT.TCTCTG	0.504985	0.354574	0.527785	0.126590	0.162859	0.148021	0.148021	0.298728	0.675342	0.654135	0.247424	0.123843	0.198148	0.793358	0.753129	0.541053	0.740954	0.308032	0.268731	0.311831	0.174724	0.213951	0.206692	0.206692	0.310745	0.335160	0.390648	0.196147	0.168175	0.209597	0.402829	0.469717	0.383694	0.375906	RRBS_NormalBCD19pCD27pcell67_88
89	RRBS_NormalBCD19pCD27pcell67_88_GCTACGCT.TGCTGC	0.461103	0.285016	0.490647	0.061652	0.073687	0.091623	0.091623	0.224748	0.583333	0.622024	0.196912	0.058647	0.151447	1.000000	0.882502	0.575498	0.874932	0.166791	0.159804	0.165718	0.099319	0.130943	0.126309	0.126309	0.179091	0.083333	0.245536	0.094161	0.100645	0.120579	0.000000	0.205599	0.257229	0.231186	RRBS_NormalBCD19pCD27pcell67_88

	filename	methylation_genesDistance	methylation_exonsDistance	methylation_intronsDistance	methylation_promoterDistance	methylation_cgiDistance	methylation_ctcfDistance	methylation_ctcfDownDistance	methylation_geneDistalRegulatoryModulesDistance	methylation_vistaEnhancersDistance	methylation_3PrimeUTRDistance	methylation_5PrimeUTRDistance	methylation_firstExonDistance	methylation_geneDistalRegulatoryModulesK562Distance	methylation_hypoInHues64Distance	methylation_intergenic	methylation_shore	methylation_shelf	PDR_genesDistance	PDR_exonsDistance	PDR_intronsDistance	PDR_promoterDistance	PDR_cgiDistance	PDR_ctcfDistance	PDR_ctcfDownDistance	PDR_geneDistalRegulatoryModulesDistance	PDR_vistaEnhancersDistance	PDR_3PrimeUTRDistance	PDR_5PrimeUTRDistance	PDR_firstExonDistance	PDR_geneDistalRegulatoryModulesK562Distance	PDR_hypoInHues64Distance	PDR_intergenic	PDR_shore	PDR_shelf	protocol
83	RRBS_NormalBCD19pCD27mcell67_88_CGTACTAG.GTGAGG	0.472029	0.279894	0.507985	0.062184	0.068979	0.099081	0.099081	0.254673	0.414678	0.646722	0.202133	0.052964	0.180330	0.825413	0.880407	0.567798	0.868663	0.162036	0.157993	0.162275	0.105846	0.134560	0.144832	0.144832	0.210529	0.343079	0.229286	0.102900	0.115445	0.160677	0.270661	0.208397	0.252791	0.195733	RRBS_NormalBCD19pCD27mcell67_88
84	RRBS_NormalBCD19pCD27mcell67_88_CGTACTAG.GTTGAG	0.475509	0.284108	0.507053	0.067481	0.074098	0.107121	0.107121	0.252745	0.376858	0.661143	0.200471	0.058478	0.178968	0.852344	0.884411	0.593522	0.879363	0.157373	0.152483	0.156989	0.105841	0.133327	0.140077	0.140077	0.195673	0.159236	0.214858	0.102166	0.103687	0.136311	0.139063	0.208999	0.275148	0.201310	RRBS_NormalBCD19pCD27mcell67_88
85	RRBS_NormalBCD19pCD27mcell67_88_CGTACTAG.TAGCGG	0.465384	0.270854	0.497950	0.070138	0.075311	0.113918	0.113918	0.265460	0.515006	0.626513	0.197863	0.054605	0.191544	0.873469	0.874056	0.568923	0.844443	0.165017	0.151922	0.166105	0.117741	0.146015	0.161420	0.161420	0.211532	0.650660	0.257800	0.104910	0.104068	0.157382	0.273469	0.210667	0.270156	0.202981	RRBS_NormalBCD19pCD27mcell67_88
86	RRBS_NormalBCD19pCD27mcell67_88_CGTACTAG.TATCTC	0.475148	0.283056	0.509076	0.067527	0.076951	0.117951	0.117951	0.258988	0.298264	0.644925	0.206166	0.057636	0.178186	0.948181	0.881155	0.586620	0.867445	0.160243	0.152014	0.161938	0.115076	0.146481	0.159352	0.159352	0.204830	0.377937	0.193244	0.110812	0.107856	0.135752	0.152150	0.215250	0.266874	0.199644	RRBS_NormalBCD19pCD27mcell67_88
87	RRBS_NormalBCD19pCD27mcell67_88_CGTACTAG.TCTCTG	0.428225	0.251018	0.461970	0.061715	0.068326	0.092568	0.092568	0.211492	0.450980	0.630726	0.171360	0.056249	0.140668	0.892283	0.877888	0.557980	0.854488	0.159956	0.156530	0.159670	0.108323	0.135232	0.156855	0.156855	0.199040	0.287582	0.263901	0.103231	0.117227	0.144726	0.075563	0.210384	0.254628	0.219492	RRBS_NormalBCD19pCD27mcell67_88

	filename	methylation_genesDistance	methylation_exonsDistance	methylation_intronsDistance	methylation_promoterDistance	methylation_cgiDistance	methylation_ctcfDistance	methylation_ctcfDownDistance	methylation_geneDistalRegulatoryModulesDistance	methylation_vistaEnhancersDistance	methylation_3PrimeUTRDistance	methylation_5PrimeUTRDistance	methylation_firstExonDistance	methylation_geneDistalRegulatoryModulesK562Distance	methylation_hypoInHues64Distance	methylation_intergenic	methylation_shore	methylation_shelf	PDR_genesDistance	PDR_exonsDistance	PDR_intronsDistance	PDR_promoterDistance	PDR_cgiDistance	PDR_ctcfDistance	PDR_ctcfDownDistance	PDR_geneDistalRegulatoryModulesDistance	PDR_vistaEnhancersDistance	PDR_3PrimeUTRDistance	PDR_5PrimeUTRDistance	PDR_firstExonDistance	PDR_geneDistalRegulatoryModulesK562Distance	PDR_hypoInHues64Distance	PDR_intergenic	PDR_shore	PDR_shelf	protocol
84	RRBS_NormalBCD19pcell67_88_TCCTGAGC.GTTGAG	0.365003	0.198154	0.403464	0.045692	0.049036	0.067145	0.067145	0.175783	0.170213	0.603492	0.133213	0.039203	0.124610	0.990164	0.857586	0.529461	0.830424	0.151630	0.135355	0.155304	0.086338	0.115382	0.124663	0.124663	0.173466	0.045593	0.233981	0.088479	0.087266	0.128772	0.000000	0.238726	0.295577	0.208543	RRBS_NormalBCD19pcell67_88
85	RRBS_NormalBCD19pcell67_88_TCCTGAGC.TAGCGG	0.427826	0.249504	0.457398	0.062149	0.072737	0.087771	0.087771	0.207407	0.428877	0.564334	0.176146	0.050720	0.137381	0.662519	0.804080	0.516266	0.779332	0.224285	0.181686	0.230307	0.109675	0.134092	0.141826	0.141826	0.200233	0.200000	0.300089	0.122736	0.101102	0.129729	0.395023	0.371977	0.332454	0.371777	RRBS_NormalBCD19pcell67_88
86	RRBS_NormalBCD19pcell67_88_TCCTGAGC.TATCTC	0.424818	0.246150	0.456708	0.058898	0.070105	0.105839	0.105839	0.221580	0.363380	0.632963	0.176894	0.050543	0.149377	0.885320	0.825866	0.539768	0.819517	0.195755	0.165491	0.200067	0.101588	0.130197	0.151039	0.151039	0.215342	0.302535	0.281348	0.112925	0.096018	0.148490	0.410017	0.335954	0.310619	0.307484	RRBS_NormalBCD19pcell67_88
87	RRBS_NormalBCD19pcell67_88_TCCTGAGC.TCTCTG	0.472135	0.286358	0.503827	0.066952	0.077275	0.107918	0.107918	0.244037	0.413347	0.619841	0.199015	0.058952	0.168218	0.894972	0.879557	0.591964	0.864421	0.157952	0.150639	0.158441	0.108958	0.132628	0.156623	0.156623	0.199528	0.254980	0.243718	0.096941	0.102134	0.130035	0.138547	0.206872	0.276050	0.196075	RRBS_NormalBCD19pcell67_88
88	RRBS_NormalBCD19pcell67_88_TCCTGAGC.TGCTGC	0.386120	0.188577	0.424230	0.057304	0.069063	0.110272	0.110272	0.226848	0.000000	0.601695	0.166264	0.051560	0.174515	0.933333	0.866931	0.560803	0.818182	0.167532	0.149592	0.180484	0.103296	0.120248	0.193353	0.193353	0.230246	0.000000	0.152542	0.106332	0.105665	0.193906	0.466667	0.299404	0.284534	0.258182	RRBS_NormalBCD19pcell67_88

	filename	methylation_genesDistance	methylation_exonsDistance	methylation_intronsDistance	methylation_promoterDistance	methylation_cgiDistance	methylation_ctcfDistance	methylation_ctcfDownDistance	methylation_geneDistalRegulatoryModulesDistance	methylation_vistaEnhancersDistance	methylation_3PrimeUTRDistance	methylation_5PrimeUTRDistance	methylation_firstExonDistance	methylation_geneDistalRegulatoryModulesK562Distance	methylation_hypoInHues64Distance	methylation_intergenic	methylation_shore	methylation_shelf	PDR_genesDistance	PDR_exonsDistance	PDR_intronsDistance	PDR_promoterDistance	PDR_cgiDistance	PDR_ctcfDistance	PDR_ctcfDownDistance	PDR_geneDistalRegulatoryModulesDistance	PDR_vistaEnhancersDistance	PDR_3PrimeUTRDistance	PDR_5PrimeUTRDistance	PDR_firstExonDistance	PDR_geneDistalRegulatoryModulesK562Distance	PDR_hypoInHues64Distance	PDR_intergenic	PDR_shore	PDR_shelf	protocol
0	RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACAA...	0.557445	0.387638	0.583685	0.148984	0.173551	0.197546	0.197546	0.330378	0.534917	0.659609	0.300969	0.142909	0.246735	0.805699	0.820512	0.590658	0.806973	0.370149	0.420504	0.359511	0.408136	0.450911	0.436709	0.436709	0.446102	0.393463	0.409348	0.376109	0.438725	0.388377	0.397393	0.379858	0.378600	0.345222	RRBS_cw154_CutSmart_protein
1	RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACCG...	0.495537	0.324467	0.521993	0.140566	0.157658	0.175575	0.175575	0.296219	0.366917	0.587535	0.261936	0.137202	0.237040	0.690698	0.796567	0.530634	0.780923	0.388093	0.435418	0.383256	0.418755	0.458484	0.442186	0.442186	0.440632	0.840602	0.376294	0.386659	0.445932	0.394716	0.346512	0.418598	0.404386	0.362456	RRBS_cw154_CutSmart_protein
2	RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACGT...	0.520409	0.357209	0.544602	0.138190	0.161856	0.202110	0.202110	0.314849	0.463004	0.656101	0.275719	0.138640	0.225783	0.761359	0.792970	0.551861	0.785731	0.383971	0.430167	0.374988	0.410647	0.455464	0.453277	0.453277	0.450694	0.324865	0.443011	0.387172	0.439933	0.414011	0.280260	0.411414	0.389000	0.363575	RRBS_cw154_CutSmart_protein
3	RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.ACTC...	0.569906	0.398614	0.595372	0.158028	0.178889	0.196911	0.196911	0.340942	0.608100	0.665446	0.310607	0.154927	0.247978	0.867355	0.831256	0.609382	0.812445	0.363173	0.416487	0.354378	0.421272	0.454977	0.438265	0.438265	0.452257	0.477332	0.376957	0.382624	0.449764	0.400321	0.171406	0.369736	0.385435	0.345905	RRBS_cw154_CutSmart_protein
4	RRBS_cw154_CutSmart_proteinase_K_TAGGCATG.AGGA...	0.554293	0.390193	0.576205	0.148946	0.173784	0.194668	0.194668	0.339245	0.494894	0.652036	0.291318	0.145185	0.250083	0.894932	0.825017	0.592558	0.807747	0.365658	0.414198	0.357211	0.407138	0.447926	0.433596	0.433596	0.428716	0.406863	0.397655	0.376272	0.425466	0.383864	0.274772	0.382212	0.378352	0.346732	RRBS_cw154_CutSmart_protein