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from bokeh.io import output_notebook
output_notebook()









    





    
        
        Loading BokehJS ...



In [2]:

    
from cameo import models
from marsi.cobra.flux_analysis import metabolite_knockout_fitness

Metabolite Knockout Landscape

This method is used to provide an overview of how different metabolite knockouts change the fitness of the model. The simulations can be run with different methods: fba, moma, room, etc.



In [3]:

    
model = models.bigg.iJO1366



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result = metabolite_knockout_fitness(model, progress=True, objective=model.reactions.BIOMASS_Ec_iJO1366_core_53p95M)



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result









    






    
        
    







    Out[5]:





<marsi.cobra.flux_analysis.analysis.MetaboliteKnockoutFitness at 0x10b8806a0>



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