In [1]:

    

from cameo import load_model


    

In [2]:

    

model = load_model("iJR904")


    

In [3]:

    

model


    

    
Out[3]:






Name
MODELID_1461534


Number of metabolites
761


Number of reactions
1075


Reactions
12ppd_dsh_S_e <=> 12ppd_dsh_S_c
h_c + nadh_c + 2dhglcn_c --> glcn_c + nad_c
h_c + nadph_c + 2dhglcn_c --> glcn_c + nadp_c
h_c + nadh_c + 2dhguln_c --> idon_dsh_L_c + nad_c
nadph_c + 2dhguln_c + h_c --> nadp_c + idon_dsh_L_c
o2_c + h_c + nadh_c + 3hcinnm_c --> nad_c + h2o_c + dhcinnm_c
h_c + nadh_c + o2_c + 3hpppn_c --> nad_c + dhpppn_c + h2o_c
h2o_c + phthr_c --> 4hthr_c + pi_c
5dglcn_c + h_c + nadph_c <=> glcn_c + nadp_c
ru5p_dsh_D_c <=> ara5p_c
ttdca_c + ACP_c + atp_c --> amp_c + myrsACP_c + ppi_c
ttdcea_c + atp_c + ACP_c --> amp_c + tdeACP_c + ppi_c
ACP_c + atp_c + hdca_c --> amp_c + palmACP_c + ppi_c
hdcea_c + ACP_c + atp_c --> amp_c + hdeACP_c + ppi_c
ocdcea_c + atp_c + ACP_c --> amp_c + octeACP_c + ppi_c
unagamu_c + dtdp4aaddg_c --> dtdp_c + unagamuf_c + h_c
h2o_c + arbt6p_c --> g6p_c + hqn_c
akg_c + 4abut_c --> glu_dsh_L_c + sucsal_c
nad_c + h2o_c + 4abutn_c --> 4abut_c + 2.0 h_c + nadh_c
h_e + 4abut_e --> 4abut_c + h_c
accoa_c + acac_c --> aacoa_c + ac_c
2.0 accoa_c <=> aacoa_c + coa_c
h_e + acac_e <=> acac_c + h_c
coa_c + nad_c + acald_c --> h_c + nadh_c + accoa_c
acald_e <=> acald_c
gtp_c + h_c + adocbip_c --> agdpcbi_c + ppi_c
hco3_c + atp_c + accoa_c <=> pi_c + h_c + adp_c + malcoa_c
coa_c + atp_c + ppa_c --> ppcoa_c + pi_c + adp_c
uacgam_c + udcpp_c --> ump_c + unaga_c
pep_c + acgam_e --> acgam6p_c + pyr_c
atp_c + acglu_c --> acg5p_c + adp_c
glu_dsh_L_c + accoa_c --> h_c + coa_c + acglu_c
h_c + pyr_c + 2obut_c --> co2_c + 2ahbut_c
atp_c + ac_c <=> actp_c + adp_c
h_c + 2.0 pyr_c --> co2_c + alac_dsh_S_c
unaga_c + uacmamu_c --> h_c + udp_c + unagamu_c
pep_c + acmana_e --> acmanap_c + pyr_c
h_e + acnam_e --> acnam_c + h_c
acnam_c --> acmana_c + pyr_c
accoa_c + ACP_c <=> coa_c + acACP_c
h2o_c + acorn_c --> orn_c + ac_c
acon_dsh_T_c + amet_c --> ahcys_c + aconm_c
cit_c <=> icit_c
akg_c + acorn_c <=> acg5sa_c + glu_dsh_L_c
apoACP_c + coa_c --> h_c + pap_c + ACP_c
coa_c + ac_c + atp_c --> accoa_c + ppi_c + amp_c
h_e + ac_e <=> ac_c + h_c
h_c + h2o_c + adn_c --> ins_c + nh4_c
4adcho_c --> h_c + 4abz_c + pyr_c
chor_c + gln_dsh_L_c --> glu_dsh_L_c + 4adcho_c
h2o_c + ade_c + h_c --> nh4_c + hxan_c
h_e + ade_e <=> ade_c + h_c
2.0 h_c + 2.0 nadh_c + accoa_c <=> coa_c + 2.0 nad_c + etoh_c
atp_c + amp_c <=> 2.0 adp_c
gtp_c + amp_c <=> gdp_c + adp_c
itp_c + amp_c <=> idp_c + adp_c
h_c + amet_c <=> co2_c + ametam_c
atp_c --> camp_c + ppi_c
atp_c + adn_c --> adp_c + amp_c + h_c
h_e + adn_e --> adn_c + h_c
h_e + adn_e <=> adn_c + h_c
atp_c + adocbi_c --> adocbip_c + adp_c + h_c
rdmbzi_c + agdpcbi_c --> gmp_c + adocbl_c + h_c
prpp_c + ade_c --> amp_c + ppi_c
atp_c + aps_c --> paps_c + adp_c + h_c
dcamp_c <=> fum_c + amp_c
25aics_c <=> aicar_c + fum_c
imp_c + asp_dsh_L_c + gtp_c --> pi_c + 2.0 h_c + gdp_c + dcamp_c
h2o_c + acgam6p_c --> ac_c + gam6p_c
adphep_dsh_DD_c --> adphep_dsh_LD_c
h2o_c + agm_c --> ptrc_c + urea_c
nadp_c + acg5sa_c + pi_c <=> acg5p_c + nadph_c + h_c
h2o_c + ahcys_c <=> hcys_dsh_L_c + adn_c
h2o_c + ahcys_c --> rhcys_c + ade_c
10fthf_c + aicar_c <=> fprica_c + thf_c
hco3_c + air_c + atp_c --> pi_c + h_c + 5caiz_c + adp_c
5aizc_c <=> 5caiz_c
coa_c + nad_c + akg_c --> succoa_c + co2_c + nadh_c
akg_e + h_e <=> h_c + akg_c
atp_c + 2.0 ala_dsh_D_c <=> pi_c + h_c + alaala_c + adp_c
ala_dsh_L_c <=> ala_dsh_D_c
ala_dsh_L_c --> ala_dsh_D_c
ala_dsh_D_c + pydx5p_c --> pyam5p_c + pyr_c
akg_c + ala_dsh_L_c <=> glu_dsh_L_c + pyr_c
pydx5p_c + ala_dsh_L_c --> pyam5p_c + pyr_c
atp_c + ala_dsh_L_e + h2o_c --> ala_dsh_L_c + pi_c + h_c + adp_c
h_e + ala_dsh_L_e <=> ala_dsh_L_c + h_c
h_c + glyald_c + nadh_c <=> glyc_c + nad_c
pacald_c + nad_c + h2o_c --> nadh_c + 2.0 h_c + pac_c
nad_c + acald_c + h2o_c --> ac_c + 2.0 h_c + nadh_c
h2o_c + alltt_c --> urdglyc_c + urea_c
h2o_c + alltn_c --> alltt_c + h_c
h_e + alltn_e <=> alltn_c + h_c
altrn_c --> 2ddglcn_c + h2o_c
malt_c + malttr_c --> maltttr_c + glc_dsh_D_c
malt_c + maltttr_c --> maltpt_c + glc_dsh_D_c
malt_c + maltpt_c --> malthx_c + glc_dsh_D_c
malt_c + malthx_c --> malthp_c + glc_dsh_D_c
acmanap_c --> acgam6p_c
acmana_c + atp_c --> h_c + adp_c + acmanap_c
8aonn_c + amet_c <=> amob_c + dann_c
2dmmq8_c + amet_c --> h_c + ahcys_c + mqn8_c
air_c + h2o_c --> 4ampm_c + 2.0 for_c + 4.0 h_c
h2o_c + amp_c --> ade_c + r5p_c
prpp_c + anth_c --> ppi_c + pran_c
gln_dsh_L_c + chor_c --> pyr_c + h_c + anth_c + glu_dsh_L_c
h_c + ala_dsh_L_c + pmcoa_c <=> coa_c + 8aonn_c + co2_c
h2o_c + ap4a_c --> 2.0 adp_c + 2.0 h_c
h2o_c + ap5a_c --> atp_c + adp_c + 2.0 h_c
nadph_c + 5apru_c + h_c --> 5aprbu_c + nadp_c
arab_dsh_L_c <=> rbl_dsh_L_c
atp_c + arab_dsh_L_e + h2o_c --> h_c + pi_c + arab_dsh_L_c + adp_c
h_e + arab_dsh_L_e <=> arab_dsh_L_c + h_c
h_c + arg_dsh_L_c --> agm_c + co2_c
orn_c + arg_dsh_L_e <=> orn_e + arg_dsh_L_c
argsuc_c <=> fum_c + arg_dsh_L_c
atp_c + asp_dsh_L_c + citr_dsh_L_c --> amp_c + argsuc_c + h_c + ppi_c
atp_c + arg_dsh_L_e + h2o_c --> arg_dsh_L_c + pi_c + h_c + adp_c
nadp_c + pi_c + aspsa_c <=> nadph_c + h_c + 4pasp_c
h2o_c + asn_dsh_L_c --> asp_dsh_L_c + nh4_c
gln_dsh_L_c + atp_c + asp_dsh_L_c + h2o_c --> amp_c + h_c + glu_dsh_L_c + ppi_c + asn_dsh_L_c
atp_c + asp_dsh_L_c + nh4_c --> amp_c + h_c + ppi_c + asn_dsh_L_c
atp_c + asn_dsh_L_e + h2o_c --> asn_dsh_L_c + pi_c + h_c + adp_c
h_e + asn_dsh_L_e <=> asn_dsh_L_c + h_c
h_c + asp_dsh_L_c --> ala_dsh_B_c + co2_c
cbp_c + asp_dsh_L_c --> cbasp_c + pi_c + h_c
atp_c + asp_dsh_L_c <=> 4pasp_c + adp_c
q8_c + asp_dsh_L_c --> iasp_c + q8h2_c
mqn8_c + asp_dsh_L_c --> iasp_c + mql8_c
fum_c + asp_dsh_L_c --> iasp_c + succ_c
o2_c + asp_dsh_L_c --> h2o2_c + iasp_c
asp_dsh_L_c --> fum_c + nh4_c
akg_c + asp_dsh_L_c <=> glu_dsh_L_c + oaa_c
atp_c + asp_dsh_L_e + h2o_c --> pi_c + h_c + asp_dsh_L_c + adp_c
h_e + asp_dsh_L_e --> asp_dsh_L_c + h_c
2.0 h_e + asp_dsh_L_e --> asp_dsh_L_c + 2.0 h_c
3.0 h_e + asp_dsh_L_e --> asp_dsh_L_c + 3.0 h_c
succoa_c + arg_dsh_L_c --> h_c + coa_c + sucarg_c
atp_c + h2o_c --> pi_c + adp_c + h_c
atp_c + prpp_c --> ppi_c + prbatp_c
pi_c + 4.0 h_e + adp_c <=> 3.0 h_c + atp_c + h2o_c
betald_c + nad_c + h2o_c --> glyb_c + 2.0 h_c + nadh_c
nadp_c + betald_c + h2o_c --> nadph_c + glyb_c + 2.0 h_c
h2o_c + pap_c --> amp_c + pi_c
btnso_c + h_c + nadh_c --> btn_c + nad_c + h2o_c
btnso_c + nadph_c + h_c --> nadp_c + h2o_c + btn_c
cys_dsh_L_c + dtbt_c <=> ala_dsh_L_c + btn_c + 2.0 h_c
but_c + accoa_c --> ac_c + btcoa_c
h_e + but_e <=> but_c + h_c
0.035 ptrc_c + 0.000129 clpn_EC_c + 0.154 glycogen_c + 0.00013 nadp_c + 0.0084 lps_EC_c + 0.0247 dttp_c + 0.007 spmd_c + 0.326 lys_dsh_L_c + 0.0254 dctp_c + 0.09 his_dsh_L_c + 0.0254 dgtp_c + 0.001935 pe_EC_c + 0.203 gtp_c + 0.488 ala_dsh_L_c + 1e-05 fad_c + 6e-06 coa_c + 0.126 ctp_c + 0.00215 nad_c + 0.003 udpg_c + 0.25 glu_dsh_L_c + 0.205 ser_dsh_L_c + 5e-05 nadh_c + 0.428 leu_dsh_L_c + 0.000464 pg_EC_c + 0.0247 datp_c + 0.136 utp_c + 0.281 arg_dsh_L_c + 0.087 cys_dsh_L_c + 0.21 pro_dsh_L_c + 0.582 gly_c + 0.0276 peptido_EC_c + 45.5608 h2o_c + 0.054 trp_dsh_L_c + 0.276 ile_dsh_L_c + 0.25 gln_dsh_L_c + 0.131 tyr_dsh_L_c + 0.229 asn_dsh_L_c + 0.241 thr_dsh_L_c + 45.7318 atp_c + 5.2e-05 ps_EC_c + 0.0004 nadph_c + 3e-06 succoa_c + 5e-05 accoa_c + 0.229 asp_dsh_L_c + 0.176 phe_dsh_L_c + 0.001 amp_c + 0.05 5mthf_c + 0.146 met_dsh_L_c + 0.402 val_dsh_L_c --> 45.5628 pi_c + 45.5608 adp_c + 45.56035 h_c + 0.7302 ppi_c
4.0 malACP_c + 10.0 nadph_c + 14.0 h_c + actACP_c --> 10.0 nadp_c + ddcaACP_c + 4.0 co2_c + 5.0 h2o_c + 4.0 ACP_c
actACP_c + 5.0 malACP_c + 12.0 nadph_c + 17.0 h_c --> 12.0 nadp_c + myrsACP_c + 6.0 h2o_c + 5.0 ACP_c + 5.0 co2_c
5.0 malACP_c + 11.0 nadph_c + 16.0 h_c + actACP_c --> 11.0 nadp_c + 5.0 ACP_c + 5.0 co2_c + 6.0 h2o_c + tdeACP_c
6.0 malACP_c + 14.0 nadph_c + 20.0 h_c + actACP_c --> 14.0 nadp_c + palmACP_c + 6.0 co2_c + 7.0 h2o_c + 6.0 ACP_c
actACP_c + 6.0 malACP_c + 13.0 nadph_c + 19.0 h_c --> 13.0 nadp_c + 6.0 co2_c + 7.0 h2o_c + 6.0 ACP_c + hdeACP_c
actACP_c + 7.0 malACP_c + 15.0 nadph_c + 22.0 h_c --> 15.0 nadp_c + 7.0 co2_c + 8.0 h2o_c + 7.0 ACP_c + octeACP_c
15dap_c + lys_dsh_L_e + h_e --> h_c + lys_dsh_L_c + 15dap_e
2.0 h2o2_c --> 2.0 h2o_c + o2_c
cbi_c + atp_c + h2o_c <=> adocbi_c + pi_c + ppi_c
cbl1_e + atp_c + h2o_c --> h_c + pi_c + cbl1_c + adp_c
atp_c + h2o_c + cbl1_c <=> pi_c + adocbl_c + ppi_c
atp_c + co2_c + nh4_c --> cbp_c + 2.0 h_c + adp_c
gln_dsh_L_c + hco3_c + 2.0 atp_c + h2o_c --> cbp_c + pi_c + 2.0 adp_c + 2.0 h_c + glu_dsh_L_c
0.02 cdpdag_EC_c + h2o_c --> cmp_c + 0.02 pa_EC_c + 2.0 h_c
4c2me_c + atp_c --> 2p4c2me_c + adp_c + h_c
chol_e + atp_c + h2o_c --> chol_c + h_c + pi_c + adp_c
chol_e + h_e <=> h_c + chol_c
chor_c --> pphn_c
3psme_c --> pi_c + chor_c
chor_c --> 4hbz_c + pyr_c
nadh_c + h_c + cinnm_c + o2_c --> nad_c + cenchddd_c
cit_c --> ac_c + oaa_c
cit_e + succ_c --> cit_c + succ_e
0.04 pg_EC_c <=> 0.02 clpn_EC_c + glyc_c
h2o_c + cmp_c --> csn_c + r5p_c
co2_e <=> co2_c
o2_c + cpppg3_c + 2.0 h_c --> pppg9_c + 2.0 co2_c + 2.0 h2o_c
crn_c + bbtcoa_c <=> crncoa_c + gbbtn_c
ctbtcoa_c + crn_c <=> crncoa_c + ctbt_c
crncoa_c <=> ctbtcoa_c + h2o_c
crn_e + gbbtn_c --> crn_c + gbbtn_e
oaa_c + h2o_c + accoa_c --> cit_c + coa_c + h_c
h2o_c + h_c + csn_c --> nh4_c + ura_c
csn_e + h_e --> csn_c + h_c
gln_dsh_L_c + utp_c + atp_c + h2o_c --> ctp_c + pi_c + adp_c + 2.0 h_c + glu_dsh_L_c
cyan_c + tsul_c --> so3_c + tcynt_c + h_c
cynt_c + 3.0 h_c + hco3_c --> 2.0 co2_c + nh4_c
h_e + cynt_e --> cynt_c + h_c
cys_dsh_L_c + h2o_c --> pyr_c + h2s_c + nh4_c
h2s_c + acser_c --> cys_dsh_L_c + h_c + ac_c
cyst_dsh_L_c + h2o_c --> pyr_c + hcys_dsh_L_c + nh4_c
atp_c + cys_dsh_L_e + h2o_c --> h_c + pi_c + cys_dsh_L_c + adp_c
2.0 h_c + 0.5 o2_c + q8h2_c --> q8_c + 2.0 h_e + h2o_c
2.5 h_c + 0.5 o2_c + q8h2_c --> q8_c + 2.5 h_e + h2o_c
h2o_c + h_c + cytd_c --> nh4_c + uri_c
gtp_c + cytd_c --> cmp_c + gdp_c + h_c
cytd_e + h_e --> cytd_c + h_c
cytd_e + h_e <=> cytd_c + h_c
cmp_c + atp_c <=> cdp_c + adp_c
atp_c + dcmp_c <=> dcdp_c + adp_c
fad_c + ala_dsh_D_c + h2o_c --> pyr_c + fadh2_c + nh4_c
h2o_c + h_c + dad_dsh_2_c --> nh4_c + din_c
atp_c + damp_c <=> adp_c + dadp_c
dad_dsh_2_e + h_e --> dad_dsh_2_c + h_c
atp_c + 0.02 12dgr_EC_c --> 0.02 pa_EC_c + adp_c + h_c
ala_dsh_D_e + h_e <=> ala_dsh_D_c + h_c
26dap_dsh_M_c + h_c --> co2_c + lys_dsh_L_c
26dap_dsh_LL_c <=> 26dap_dsh_M_c
26dap_dsh_M_e + atp_c + h2o_c --> 26dap_dsh_M_c + h_c + pi_c + adp_c
h_c + 0.02 pa_EC_c + ctp_c <=> 0.02 cdpdag_EC_c + ppi_c
ru5p_dsh_D_c --> h_c + db4p_c + for_c
atp_c + co2_c + dann_c <=> dtbt_c + 3.0 h_c + pi_c + adp_c
h_c + h2o_c + dctp_c --> dutp_c + nh4_c
h_c + h2o_c + dcyt_c --> duri_c + nh4_c
h_e + dcyt_e --> dcyt_c + h_c
2dh3dgal_c + atp_c --> 2dh3dgal6p_c + adp_c + h_c
2ddglcn_e + h_e <=> 2ddglcn_c + h_c
2ddglcn_c + atp_c --> h_c + adp_c + 2ddg6p_c
h2o_c + e4p_c + pep_c --> pi_c + 2dda7p_c
2dh3dgal6p_c <=> g3p_c + pyr_c
atp_c + dgmp_c <=> dgdp_c + adp_c
dgsn_e + h_e --> dgsn_c + h_c
23dhmb_c --> 3mob_c + h2o_c
23dhmp_c --> 3mop_c + h2o_c
dha_c + pep_c --> dhap_c + pyr_c
dha_e <=> dha_c
nad_c + 23ddhb_c <=> nadh_c + 23dhb_c + h_c
23dhb_c + atp_c <=> ppi_c + 23dhba_c
cenchddd_c + nad_c --> dhcinnm_c + nadh_c + h_c
dhcinnm_c + o2_c --> hkntd_c
h_c + nadph_c + 23dhdp_c --> thdp_c + nadp_c
aspsa_c + pyr_c --> h_c + 23dhdp_c + 2.0 h2o_c
h_c + nadph_c + dhf_c <=> thf_c + nadp_c
dhpt_c + atp_c + glu_dsh_L_c --> dhf_c + pi_c + adp_c
octdp_c + dhna_c --> 2dmmq8_c + h_c + co2_c + ppi_c
dhnpt_c --> 6hmhpt_c + gcald_c
q8_c + dhor_dsh_S_c --> orot_c + q8h2_c
mqn8_c + dhor_dsh_S_c --> orot_c + mql8_c
h2o_c + dhor_dsh_S_c <=> cbasp_c + h_c
cechddd_c + nad_c --> nadh_c + dhpppn_c + h_c
25drapp_c + h_c + h2o_c --> 5apru_c + nh4_c
4abz_c + 6hmhptpp_c --> h_c + dhpt_c + ppi_c
dhptd_c --> h2o_c + hmfurn_c
3dhq_c <=> 3dhsk_c + h2o_c
2dda7p_c --> pi_c + 3dhq_c
h_e + din_e --> din_c + h_c
25dkglcn_c + h_c + nadph_c --> 2dhguln_c + nadp_c
25dkglcn_c + h_c + nadh_c --> 5dglcn_c + nad_c
25dkglcn_c + h_c + nadph_c --> 5dglcn_c + nadp_c
o2_c + h2o_c + dkmpp_c --> 2kmb_c + pi_c + 2.0 h_c + for_c
3.0 h2o_c + dkmpp_c --> 2kmb_c + pi_c + 6.0 h_c + for_c
dmpp_c + ipdp_c --> ppi_c + grdp_c
h2mb4p_c + h_c + nadh_c --> dmpp_c + nad_c + h2o_c
amet_c + 2omhmbl_c --> q8h2_c + ahcys_c + h_c
dmso_c + mql8_c --> dms_c + mqn8_c + h2o_c
dmso_e + mql8_c --> dms_e + mqn8_c + h2o_e
dmso_c + 2dmmql8_c --> 2dmmq8_c + dms_c + h2o_c
dmso_e + 2dmmql8_c --> 2dmmq8_c + dms_e + h2o_e
h2o_c + dhpmp_c --> dhnpt_c + pi_c
h2o_c + ahdt_c --> dhpmp_c + ppi_c + h_c
23doguln_c + h_c + nadh_c --> 3dhguln_c + nad_c
dpcoa_c + atp_c --> coa_c + adp_c + h_c
nadph_c + h_c + 2dhp_c --> nadp_c + pant_dsh_R_c
2dr5p_c --> g3p_c + acald_c
h_e + ser_dsh_D_e <=> h_c + ser_dsh_D_c
atp_c + dtmp_c <=> dtdp_c + adp_c
atp_c + duri_c --> dump_c + adp_c + h_c
pi_c + duri_c <=> 2dr1p_c + ura_c
h_e + duri_e --> duri_c + h_c
h2o_c + dutp_c --> dump_c + ppi_c + h_c
h_c + nadph_c + dxyl5p_c --> 2me4p_c + nadp_c
g3p_c + h_c + pyr_c --> co2_c + dxyl5p_c
atp_c + dxyl_c --> dxyl5p_c + adp_c + h_c
h_e + lac_dsh_D_e <=> h_c + lac_dsh_D_c
nad_c + e4p_c + h2o_c <=> 4per_c + 2.0 h_c + nadh_c
unagamuf_c --> udcpdp_c + h_c + eca_EC_c
2ddg6p_c --> g3p_c + pyr_c
6pgc_c --> 2ddg6p_c + h2o_c
kdo2lipid4_c + ddcaACP_c --> ACP_c + kdo2lipid4L_c
myrsACP_c + kdo2lipid4L_c --> lipa_c + ACP_c
kdo2lipid4_c + hdeACP_c --> kdo2lipid4p_c + ACP_c
myrsACP_c + kdo2lipid4p_c --> lipa_cold_c + ACP_c
2pg_c <=> h2o_c + pep_c
3.0 23dhba_c + 3.0 seramp_c --> enter_c + 6.0 amp_c + 6.0 h_c
etha_c --> acald_c + nh4_c
h_e + etoh_e <=> etoh_c + h_c
12ppd_dsh_S_e --> 
15dap_e --> 
26dap_dsh_M_e --> 
2ddglcn_e --> 
3hcinnm_e --> 
3hpppn_e --> 
4abut_e --> 
ac_e --> 
acac_e --> 
acald_e --> 
acgam_e --> 
acmana_e --> 
acnam_e --> 
ade_e --> 
adn_e --> 
akg_e --> 
ala_dsh_D_e --> 
ala_dsh_L_e --> 
alltn_e --> 
amp_e --> 
arab_dsh_L_e --> 
arg_dsh_L_e --> 
asn_dsh_L_e --> 
asp_dsh_L_e --> 
but_e --> 
cbl1_e --> 
chol_e --> 
cit_e --> 
co2_e <=> 
crn_e --> 
csn_e --> 
cynt_e --> 
cys_dsh_L_e --> 
cytd_e --> 
dad_dsh_2_e --> 
dcyt_e --> 
dgsn_e --> 
dha_e --> 
din_e --> 
dms_e --> 
dmso_e --> 
duri_e --> 
etoh_e --> 
fe2_e <=> 
for_e --> 
fru_e --> 
fuc1p_dsh_L_e --> 
fuc_dsh_L_e --> 
fum_e --> 
g6p_e --> 
gal_e --> 
galct_dsh_D_e --> 
galctn_dsh_D_e --> 
galt_e --> 
galur_e --> 
gam_e --> 
gbbtn_e --> 
glc_dsh_D_e <-- 
glcn_e --> 
glcr_e --> 
glcur_e --> 
gln_dsh_L_e --> 
glu_dsh_L_e --> 
gly_e --> 
glyald_e --> 
glyb_e --> 
glyc3p_e --> 
glyc_e --> 
glyclt_e --> 
gsn_e --> 
gua_e --> 
h2o_e <=> 
h_e <=> 
hdca_e --> 
his_dsh_L_e --> 
hxan_e --> 
idon_dsh_L_e --> 
ile_dsh_L_e --> 
indole_e --> 
ins_e --> 
k_e <=> 
lac_dsh_D_e --> 
lac_dsh_L_e --> 
lcts_e --> 
leu_dsh_L_e --> 
lys_dsh_L_e --> 
mal_dsh_L_e --> 
malt_e --> 
malthx_e --> 
maltpt_e --> 
malttr_e --> 
maltttr_e --> 
man6p_e --> 
man_e --> 
melib_e --> 
met_dsh_D_e --> 
met_dsh_L_e --> 
mnl_e --> 
na1_e <=> 
nac_e --> 
nad_e --> 
nh4_e <=> 
nmn_e --> 
no2_e --> 
no3_e --> 
o2_e <-- 
ocdca_e --> 
orn_e --> 
phe_dsh_L_e --> 
pi_e <=> 
pnto_dsh_R_e --> 
pppn_e --> 
pro_dsh_L_e --> 
ptrc_e --> 
pyr_e --> 
rib_dsh_D_e --> 
rmn_e --> 
sbt_dsh_D_e --> 
ser_dsh_D_e --> 
ser_dsh_L_e --> 
so4_e <=> 
spmd_e --> 
succ_e --> 
sucr_e --> 
tartr_dsh_L_e --> 
taur_e --> 
thm_e --> 
thr_dsh_L_e --> 
thymd_e --> 
tma_e --> 
tmao_e --> 
tre_e --> 
trp_dsh_L_e --> 
tsul_e --> 
ttdca_e --> 
tyr_dsh_L_e --> 
ura_e --> 
urea_e --> 
uri_e --> 
val_dsh_L_e --> 
xan_e --> 
xtsn_e --> 
xyl_dsh_D_e --> 
f6p_c <=> dha_c + g3p_c
6.0 fad_c + 7.0 coa_c + atp_c + ttdca_c + 6.0 nad_c + 6.0 h2o_c --> 6.0 fadh2_c + 7.0 accoa_c + 6.0 h_c + 6.0 nadh_c + ppi_c + amp_c
7.0 fad_c + 8.0 coa_c + atp_c + 7.0 nad_c + hdca_c + 7.0 h2o_c --> 7.0 fadh2_c + 8.0 accoa_c + 7.0 h_c + 7.0 nadh_c + ppi_c + amp_c
8.0 fad_c + 9.0 coa_c + atp_c + 8.0 nad_c + ocdca_c + 8.0 h2o_c --> 8.0 fadh2_c + 9.0 accoa_c + 8.0 h_c + 8.0 nadh_c + ppi_c + amp_c
fad_c + nad_c + btcoa_c + h2o_c --> h_c + fadh2_c + nadh_c + aacoa_c
fdp_c <=> dhap_c + g3p_c
fdp_c + h2o_c --> pi_c + f6p_c
fuc_dsh_L_c <=> fcl_dsh_L_c
atp_c + fcl_dsh_L_c --> fc1p_c + adp_c + h_c
fc1p_c <=> dhap_c + lald_dsh_L_c
fe2_c + ppp9_c --> 2.0 h_c + pheme_c
3.0 h_c + q8_c + for_c --> 2.0 h_e + q8h2_c + co2_c
mqn8_c + 3.0 h_c + for_c --> 2.0 h_e + mql8_c + co2_c
atp_c + fe2_e + h2o_c --> h_c + pi_c + fe2_c + adp_c
h2o_c + suc6p_c --> g6p_c + fru_c
h_c + for_c --> co2_c + h2_c
atp_c + h_c + fmn_c --> ppi_c + fad_c
for_e <=> for_c
fum_c + mql8_c --> mqn8_c + succ_c
fum_c + 2dmmql8_c --> 2dmmq8_c + succ_c
atp_c + f1p_c --> adp_c + fdp_c + h_c
fru_e + pep_c --> f1p_c + pyr_c
fru_e + pep_c --> f6p_c + pyr_c
10fthf_c + h2o_c --> thf_c + for_c + h_c
fuc1p_dsh_L_e + 2.0 pi_c --> 2.0 pi_e + fuc1p_dsh_L_c
fuc_dsh_L_e + h_e <=> fuc_dsh_L_c + h_c
fum_c + h2o_c <=> mal_dsh_L_c
fum_e + 2.0 h_e --> fum_c + 2.0 h_c
fum_e + 3.0 h_e --> fum_c + 3.0 h_c
gam1p_c + accoa_c --> h_c + acgam1p_c + coa_c
g1p_c + h2o_c --> pi_c + glc_dsh_D_c
dttp_c + g1p_c + h_c --> ppi_c + dtdpglu_c
glu1sa_c --> 5aop_c
nadp_c + glyc3p_c <=> dhap_c + h_c + nadph_c
q8_c + glyc3p_c --> dhap_c + q8h2_c
mqn8_c + glyc3p_c --> dhap_c + mql8_c
glyc3p_c + 2dmmq8_c --> dhap_c + 2dmmql8_c
glu5sa_c --> 1pyr5c_c + h_c + h2o_c
nadph_c + h_c + glu5p_c --> nadp_c + glu5sa_c + pi_c
h2o_c + gam6p_c --> f6p_c + nh4_c
nadp_c + g6p_c <=> h_c + 6pgl_c + nadph_c
g6p_e + 2.0 pi_c --> g6p_c + 2.0 pi_e
galct_dsh_D_c --> 5dh4dglc_c + h2o_c
galctn_dsh_D_c --> 2dh3dgal_c + h2o_c
h_e + galctn_dsh_D_e <=> galctn_dsh_D_c + h_c
galct_dsh_D_e + h_e <=> galct_dsh_D_c + h_c
atp_c + gal_c <=> adp_c + gal1p_c + h_c
h2o_c + melib_c --> gal_c + glc_dsh_D_c
pep_c + galt_e --> galt1p_c + pyr_c
g1p_c + h_c + utp_c <=> udpg_c + ppi_c
h_e + galur_e <=> galur_c + h_c
g1p_c + h_c + utp_c --> udpg_c + ppi_c
gal_e + atp_c + h2o_c --> gal_c + h_c + pi_c + adp_c
gal_e + h_e --> gal_c + h_c
gam_e + pep_c --> gam6p_c + pyr_c
nad_c + pi_c + g3p_c <=> h_c + nadh_c + 13dpg_c
10fthf_c + gar_c <=> fgam_c + thf_c + h_c
atp_c + for_c + gar_c --> fgam_c + pi_c + h_c + adp_c
nad_c + gcald_c + h2o_c --> 2.0 h_c + glyclt_c + nadh_c
gdpddman_c --> gdpofuc_c
gln_dsh_L_c + f6p_c --> glu_dsh_L_c + gam6p_c
thf_c + ser_dsh_L_c --> mlthf_c + h2o_c + gly_c
atp_c + gmp_c <=> gdp_c + adp_c
h2o_e + glc_dsh_D_e + q8_c --> glcn_e + h_e + q8h2_c
glcn_e + h_e <=> glcn_c + h_c
glycogen_c + pi_c --> g1p_c
5dh4dglc_c --> pyr_c + 2h3oppan_c
glcr_c --> 5dh4dglc_c + h2o_c
glcr_e + h_e <=> glcr_c + h_c
adpglc_c --> glycogen_c + adp_c + h_c
glcur_e + h_e <=> glcur_c + h_c
glc_dsh_D_e + pep_c --> g6p_c + pyr_c
glc_dsh_D_e + h_e --> glc_dsh_D_c + h_c
atp_c + g1p_c + h_c --> adpglc_c + ppi_c
glu_dsh_L_c + atp_c + nh4_c --> gln_dsh_L_c + h_c + pi_c + adp_c
gln_dsh_L_e + atp_c + h2o_c --> gln_dsh_L_c + h_c + pi_c + adp_c
galt1p_c + nad_c <=> h_c + nadh_c + tag6p_dsh_D_c
atp_c + glu_dsh_L_c --> adp_c + glu5p_c
glu_dsh_L_e + 4abut_c <=> glu_dsh_L_c + 4abut_e
glu_dsh_L_c + cys_dsh_L_c + atp_c --> h_c + pi_c + glucys_c + adp_c
h_c + glu_dsh_L_c --> 4abut_c + co2_c
nadp_c + h2o_c + glu_dsh_L_c <=> akg_c + nadph_c + h_c + nh4_c
gln_dsh_L_c + h2o_c --> glu_dsh_L_c + nh4_c
gln_dsh_L_c + prpp_c + h2o_c --> glu_dsh_L_c + pram_c + ppi_c
glu_dsh_D_c <=> glu_dsh_L_c
gln_dsh_L_c + nadph_c + h_c + akg_c --> nadp_c + 2.0 glu_dsh_L_c
nadph_c + h_c + glutrna_c --> nadp_c + glu1sa_c + trnaglu_c
trnaglu_c + glu_dsh_L_c + atp_c --> amp_c + glutrna_c + ppi_c
glu_dsh_L_e + atp_c + h2o_c --> pi_c + glu_dsh_L_c + h_c + adp_c
h_e + glu_dsh_L_e <=> glu_dsh_L_c + h_c
glu_dsh_L_e + na1_e --> glu_dsh_L_c + na1_c
2.0 glx_c + h_c --> co2_c + 2h3oppan_c
glyald_e <=> glyald_c
coa_c + 2aobut_c --> gly_c + accoa_c
atp_c + glyb_e + h2o_c --> glyb_c + pi_c + h_c + adp_c
h_e + glyb_e <=> glyb_c + h_c
atp_c + glyc3p_e + h2o_c --> pi_c + glyc3p_c + h_c + adp_c
glyc3p_e + pi_c --> glyc3p_c + pi_e
glyc_c + nad_c --> dha_c + nadh_c + h_c
atp_c + glyc_dsh_R_c --> 3pg_c + adp_c + h_c
gly_c + thf_c + nad_c --> mlthf_c + nadh_c + co2_c + nh4_c
glx_c + h_c + nadh_c --> glyclt_c + nad_c
nadph_c + h_c + glx_c --> nadp_c + glyclt_c
glyclt_e + h_e <=> glyclt_c + h_c
glyclt_c + q8_c --> q8h2_c + glx_c
glyclt_c + mqn8_c --> glx_c + mql8_c
glyclt_c + 2dmmq8_c --> 2dmmql8_c + glx_c
glyc_c <=> glyc_e
atp_c + glyc_c --> glyc3p_c + adp_c + h_c
h2o_c + lgt_dsh_S_c --> gthrd_c + lac_dsh_D_c + h_c
h_e + gly_e <=> gly_c + h_c
gdpmann_c --> gdpddman_c + h2o_c
atp_c + gmhep1p_c + h_c --> adphep_dsh_DD_c + ppi_c
atp_c + gmhep7p_c --> adp_c + gmhep17bp_c + h_c
gmhep17bp_c + h2o_c --> pi_c + gmhep1p_c
gmp_c + nadph_c + 2.0 h_c --> nadp_c + nh4_c + imp_c
gln_dsh_L_c + xmp_c + atp_c + h2o_c --> amp_c + gmp_c + glu_dsh_L_c + 2.0 h_c + ppi_c
nadp_c + 6pgc_c --> co2_c + ru5p_dsh_D_c + nadph_c
atp_c + glcn_c --> 6pgc_c + adp_c + h_c
nadph_c + h_c + gdpofuc_c --> nadp_c + gdpfuc_c
gp4g_c + h2o_c --> 2.0 gdp_c + 2.0 h_c
g3pc_c + h2o_c --> h_c + glyc3p_c + chol_c
h2o_c + g3pe_c --> etha_c + glyc3p_c + h_c
h2o_c + g3ps_c --> glyc3p_c + h_c + ser_dsh_L_c
g3pg_c + h2o_c --> glyc_c + glyc3p_c + h_c
g3pi_c + h2o_c --> inost_c + glyc3p_c + h_c
grdp_c + ipdp_c --> ppi_c + frdp_c
gsn_c + atp_c --> adp_c + gmp_c + h_c
gsn_e + h_e --> gsn_c + h_c
h2o_c + gtspmd_c --> gthrd_c + spmd_c
atp_c + gthrd_c + spmd_c --> gtspmd_c + pi_c + h_c + adp_c
nadph_c + h_c + gthox_c <=> nadp_c + 2.0 gthrd_c
gly_c + glucys_c + atp_c --> gthrd_c + h_c + pi_c + adp_c
h2o_c + gtp_c --> ahdt_c + for_c
gtp_c + 3.0 h2o_c --> 25drapp_c + 2.0 h_c + for_c + ppi_c
h_c + h2o_c + gua_c --> xan_c + nh4_c
prpp_c + gua_c --> ppi_c + gmp_c
gua_e <=> gua_c
gua_e + h_e --> gua_c + h_c
glcur_c <=> fruur_c
galur_c <=> tagur_c
h2o_e <=> h2o_c
4hbz_c + octdp_c --> ppi_c + 3ophb_c
3hcinnm_e + h_e <=> 3hcinnm_c + h_c
h2o_c + co2_c <=> h_c + hco3_c
h_e + hdca_e --> h_c + hdca_c
h2o_c + pheme_c + frdp_c --> ppi_c + hemeO_c
atp_c + 4mhetz_c --> 4mpetz_c + adp_c + h_c
atp_c + glc_dsh_D_c --> g6p_c + adp_c + h_c
histd_c + 2.0 nad_c + h2o_c --> his_dsh_L_c + 3.0 h_c + 2.0 nadh_c
hisp_c + h2o_c --> histd_c + pi_c
atp_c + his_dsh_L_e + h2o_c --> his_dsh_L_c + h_c + pi_c + adp_c
h_e + his_dsh_L_e <=> his_dsh_L_c + h_c
h2o_c + hkndd_c --> 2.0 h_c + op4en_c + succ_c
hkntd_c + h2o_c --> fum_c + op4en_c + 2.0 h_c
h2o_c + 4.0 ppbng_c --> hmbil_c + 4.0 nh4_c
atp_c + 4ahmmp_c --> 4ampm_c + adp_c + h_c
4h2opntn_c --> acald_c + pyr_c
atp_c + 6hmhpt_c --> 6hmhptpp_c + amp_c + h_c
o2_c + dhpppn_c --> hkndd_c
3hpppn_e + h_e <=> 3hpppn_c + h_c
hpyr_c <=> 2h3oppan_c
hpyr_c + h_c + nadh_c --> glyc_dsh_R_c + nad_c
hpyr_c + h_c + nadph_c --> glyc_dsh_R_c + nadp_c
nadp_c + hom_dsh_L_c <=> h_c + aspsa_c + nadph_c
atp_c + hom_dsh_L_c --> phom_c + adp_c + h_c
succoa_c + hom_dsh_L_c --> suchms_c + coa_c
imacp_c + glu_dsh_L_c --> akg_c + hisp_c
prpp_c + hxan_c --> imp_c + ppi_c
2.0 h_c + h2_c + q8_c --> q8h2_c + 2.0 h_e
2.0 h_c + h2_c + mqn8_c --> mql8_c + 2.0 h_e
2.0 h_c + h2_c + 2dmmq8_c --> 2dmmql8_c + 2.0 h_e
pyam5p_c + h2o_c --> pydam_c + pi_c
hxan_e <=> hxan_c
nadp_c + icit_c <=> co2_c + akg_c + nadph_c
chor_c --> ichor_c
h2o_c + ichor_c --> 23ddhb_c + pyr_c
icit_c --> glx_c + succ_c
5dglcn_c + h_c + nadh_c <=> idon_dsh_L_c + nad_c
5dglcn_c + nadph_c + h_c --> nadp_c + idon_dsh_L_c
h_e + idon_dsh_L_e <=> h_c + idon_dsh_L_c
gln_dsh_L_c + prlp_c --> eig3p_c + aicar_c + h_c + glu_dsh_L_c
eig3p_c --> imacp_c + h2o_c
h_c + 2cpr5p_c --> co2_c + 3ig3p_c + h2o_c
akg_c + ile_dsh_L_c <=> glu_dsh_L_c + 3mop_c
atp_c + ile_dsh_L_e + h2o_c --> ile_dsh_L_c + pi_c + h_c + adp_c
h_e + ile_dsh_L_e <=> h_c + ile_dsh_L_c
h2o_c + imp_c <=> fprica_c
nad_c + h2o_c + imp_c --> xmp_c + h_c + nadh_c
indole_e + h_e <=> indole_c + h_c
atp_c + ins_c --> imp_c + adp_c + h_c
h_e + ins_e --> ins_c + h_c
h_e + ins_e <=> ins_c + h_c
ipdp_c --> dmpp_c
h_c + h2mb4p_c + nadh_c --> nad_c + ipdp_c + h2o_c
3c2hmp_c + nad_c --> nadh_c + 3c4mop_c + h_c
3c2hmp_c <=> 2ippm_c + h2o_c
h2o_c + 2ippm_c <=> 3c3hmp_c
3mob_c + h2o_c + accoa_c --> 3c3hmp_c + h_c + coa_c
h_c + nadph_c + alac_dsh_S_c --> 23dhmb_c + nadp_c
h_c + nadph_c + 2ahbut_c --> 23dhmp_c + nadp_c
acACP_c + malACP_c + h_c --> co2_c + ACP_c + actACP_c
malACP_c + h_c + accoa_c --> coa_c + actACP_c + co2_c
malACP_c + nadph_c + ddcaACP_c + 2.0 h_c --> nadp_c + 3hmrsACP_c + co2_c + ACP_c
ctp_c + kdo_c --> ckdo_c + ppi_c
h2o_c + kdo8p_c --> kdo_c + pi_c
h2o_c + ara5p_c + pep_c --> kdo8p_c + pi_c
h_c + 3dhgulnp_c --> co2_c + xu5p_dsh_L_c
atp_c + k_e + h2o_c --> k_c + pi_c + h_c + adp_c
h_e + k_e <=> h_c + k_c
h2o_c + lcts_c --> gal_c + glc_dsh_D_c
lald_dsh_L_c + nad_c + h2o_c <=> 2.0 h_c + lac_dsh_L_c + nadh_c
lald_dsh_L_c + nad_c + h2o_c --> 2.0 h_c + lac_dsh_L_c + nadh_c
h_c + nadh_c + lald_dsh_L_c <=> nad_c + 12ppd_dsh_S_c
h_e + lcts_e <=> h_c + lcts_c
nad_c + lac_dsh_D_c <=> h_c + nadh_c + pyr_c
q8_c + lac_dsh_D_c --> pyr_c + q8h2_c
4mop_c + glu_dsh_L_c --> akg_c + leu_dsh_L_c
leu_dsh_L_e + atp_c + h2o_c --> pi_c + leu_dsh_L_c + h_c + adp_c
h_e + leu_dsh_L_e <=> h_c + leu_dsh_L_c
gthrd_c + mthgxl_c --> lgt_dsh_S_c
u23ga_c + lipidX_c --> udp_c + h_c + lipidAds_c
0.02 agpg_EC_c + h2o_c --> g3pg_c + 0.07 hdcea_c + 0.5 ocdcea_c + h_c + 0.36 hdca_c + 0.02 ttdca_c + 0.05 ttdcea_c
h2o_c + 0.02 agpe_EC_c --> 0.07 hdcea_c + 0.5 ocdcea_c + h_c + 0.36 hdca_c + 0.02 ttdca_c + 0.05 ttdcea_c + g3pe_c
0.02 agpc_EC_c + h2o_c --> h_c + 0.07 hdcea_c + 0.5 ocdcea_c + 0.36 hdca_c + g3pc_c + 0.02 ttdca_c + 0.05 ttdcea_c
0.02 agpe_EC_c + 0.02 pg_EC_c --> g3pe_c + 0.02 apg_EC_c
0.02 agpc_EC_c + 0.02 pg_EC_c --> 0.02 apg_EC_c + g3pc_c
0.02 agpg_EC_c + 0.02 pg_EC_c --> 0.02 apg_EC_c + g3pg_c
2.0 cdpea_c + 2.0 udpg_c + lipa_c + 3.0 ckdo_c + 3.0 adphep_dsh_LD_c --> 10.0 h_c + lps_EC_c + 3.0 cmp_c + 2.0 cdp_c + 2.0 udp_c + 3.0 adp_c
h_c + lys_dsh_L_c --> co2_c + 15dap_c
lys_dsh_L_e + atp_c + h2o_c --> lys_dsh_L_c + pi_c + h_c + adp_c
h_e + lys_dsh_L_e <=> h_c + lys_dsh_L_c
q8_c + lac_dsh_L_c --> pyr_c + q8h2_c
mqn8_c + lac_dsh_L_c --> pyr_c + mql8_c
h_e + lac_dsh_L_e <=> h_c + lac_dsh_L_c
nad_c + mnl1p_c <=> nadh_c + f6p_c + h_c
h_c + malACP_c --> co2_c + acACP_c
glx_c + h2o_c + accoa_c --> coa_c + mal_dsh_L_c + h_c
atp_c + malthx_e + h2o_c --> malthx_c + h_c + pi_c + adp_c
maltpt_e + atp_c + h2o_c --> h_c + pi_c + maltpt_c + adp_c
atp_c + malttr_e + h2o_c --> malttr_c + h_c + pi_c + adp_c
maltttr_e + atp_c + h2o_c --> h_c + pi_c + maltttr_c + adp_c
atp_c + malt_e + h2o_c --> malt_c + pi_c + h_c + adp_c
malt_e + pep_c --> malt6p_c + pyr_c
2.0 h_e + mal_dsh_L_e --> 2.0 h_c + mal_dsh_L_c
3.0 h_e + mal_dsh_L_e --> 3.0 h_c + mal_dsh_L_c
h_c + man1p_c + gdp_c --> pi_c + gdpmann_c
man6p_c <=> f6p_c
2.0 pi_c + man6p_e --> man6p_c + 2.0 pi_e
nad_c + mana_c <=> nadh_c + fruur_c + h_c
man_e + pep_c --> man6p_c + pyr_c
2mcit_c --> 2mcacn_c + h2o_c
micit_c <=> succ_c + pyr_c
oaa_c + ppcoa_c + h2o_c --> coa_c + h_c + 2mcit_c
malcoa_c + ACP_c <=> coa_c + malACP_c
nad_c + mal_dsh_L_c <=> h_c + oaa_c + nadh_c
q8_c + mal_dsh_L_c --> oaa_c + q8h2_c
mqn8_c + mal_dsh_L_c --> oaa_c + mql8_c
5mdru1p_c --> dkmpp_c + h2o_c
nad_c + mal_dsh_L_c --> co2_c + nadh_c + pyr_c
nadp_c + mal_dsh_L_c --> pyr_c + co2_c + nadph_c
h_c + 2mecdp_c --> h2mb4p_c + h2o_c
2p4c2me_c --> 2mecdp_c + cmp_c
h_e + melib_e --> h_c + melib_c
2me4p_c + ctp_c + h_c --> ppi_c + 4c2me_c
atp_c + h2o_c + met_dsh_L_c --> amet_c + pi_c + ppi_c
atp_c + met_dsh_D_e + h2o_c --> met_dsh_D_c + pi_c + h_c + adp_c
5mthf_c + hcys_dsh_L_c --> met_dsh_L_c + thf_c
atp_c + met_dsh_L_e + h2o_c --> pi_c + adp_c + h_c + met_dsh_L_c
dhap_c --> mthgxl_c + pi_c
h2o_c + mi1p_dsh_D_c --> pi_c + inost_c
2mcacn_c + h2o_c --> micit_c
malttr_c + h2o_c --> malt_c + glc_dsh_D_c
maltttr_c + h2o_c --> malttr_c + glc_dsh_D_c
maltpt_c + h2o_c --> maltttr_c + glc_dsh_D_c
malthx_c + h2o_c --> maltpt_c + glc_dsh_D_c
malthp_c + h2o_c --> malthx_c + glc_dsh_D_c
pi_c + maltpt_c <=> maltttr_c + g1p_c
pi_c + malthx_c <=> maltpt_c + g1p_c
pi_c + malthp_c <=> malthx_c + g1p_c
mmcoa_dsh_S_c + h_c --> ppcoa_c + co2_c
mmcoa_dsh_R_c <=> mmcoa_dsh_S_c
succoa_c --> mmcoa_dsh_R_c
mnl_e + pep_c --> mnl1p_c + pyr_c
mana_c --> 2ddglcn_c + h2o_c
ckdo_c + lipidA_c --> cmp_c + kdolipid4_c + h_c
ckdo_c + kdolipid4_c --> cmp_c + kdo2lipid4_c + h_c
3mob_c + h2o_c + mlthf_c --> 2dhp_c + thf_c
5mta_c + h2o_c --> 5mtr_c + ade_c
h2o_c + methf_c <=> 10fthf_c
mlthf_c + nadp_c <=> h_c + methf_c + nadph_c
mlthf_c + h_c + nadh_c --> nad_c + 5mthf_c
5mdr1p_c <=> 5mdru1p_c
atp_c + 5mtr_c --> 5mdr1p_c + adp_c + h_c
h2o_c + acg5sa_c --> glu5sa_c + ac_c
nac_e --> nac_c
h2o_c + nad_c --> nmn_c + amp_c + 2.0 h_c
h2o_e + nad_e --> nmn_e + amp_e + 2.0 h_e
h_c + nadh_c + mqn8_c --> mql8_c + nad_c
h_c + nadh_c + q8_c --> q8h2_c + nad_c
4.5 h_c + q8_c + nadh_c --> nad_c + q8h2_c + 3.5 h_e
mqn8_c + 3.0 h_c + nadh_c --> nad_c + 2.0 h_e + mql8_c
2dmmq8_c + 3.8 h_c + nadh_c --> nad_c + 2dmmql8_c + 2.8 h_e
h_c + 2dmmq8_c + nadh_c --> 2dmmql8_c + nad_c
atp_c + nad_c --> h_c + adp_c + nadp_c
h2o_c + nadp_c --> pi_c + nad_c
atp_c + dnad_c + nh4_c --> amp_c + h_c + nad_c + ppi_c
nad_c + nadph_c --> nadh_c + nadp_c
prpp_c + atp_c + nac_c + h2o_c --> nicrnt_c + pi_c + adp_c + ppi_c
na1_c + h_e <=> na1_e + h_c
2.0 na1_c + 3.0 h_e --> 2.0 na1_e + 3.0 h_c
na1_c + 2.0 h_e --> na1_e + 2.0 h_c
atp_c + gdp_c <=> gtp_c + adp_c
atp_c + udp_c <=> adp_c + utp_c
cdp_c + atp_c <=> adp_c + ctp_c
atp_c + dtdp_c <=> dttp_c + adp_c
atp_c + dgdp_c <=> adp_c + dgtp_c
atp_c + dudp_c <=> dutp_c + adp_c
atp_c + dcdp_c <=> dctp_c + adp_c
atp_c + dadp_c <=> adp_c + datp_c
nh4_e <=> nh4_c
atp_c + h_c + nmn_c --> nad_c + ppi_c
h2o_c + nmn_c --> nicrnt_c + nh4_c
h2o_c + nmn_c --> r5p_c + h_c + ncam_c
nmn_e --> nmn_c
h2o_c + nmn_e --> h_c + r5p_c + ncam_c
ncam_c + h2o_c --> nac_c + nh4_c
atp_c + h_c + nicrnt_c --> dnad_c + ppi_c
dmbzid_c + nicrnt_c --> nac_c + 5prdmbz_c + h_c
quln_c + prpp_c + 2.0 h_c --> nicrnt_c + co2_c + ppi_c
h_e + no2_e <=> no2_c + h_c
2.0 h_c + q8h2_c + no3_c --> no2_c + q8_c + 2.0 h_e + h2o_c
2.0 h_c + no3_c + mql8_c --> mqn8_c + no2_c + 2.0 h_e + h2o_c
no2_c + no3_e --> no3_c + no2_e
sbzcoa_c --> dhna_c + coa_c
h2o_c + dump_c --> duri_c + pi_c
h2o_c + xmp_c --> pi_c + xtsn_c
h2o_c + imp_c --> pi_c + ins_c
h2o_c + ump_c --> pi_c + uri_c
h2o_c + dcmp_c --> dcyt_c + pi_c
h2o_c + cmp_c --> cytd_c + pi_c
h2o_c + dtmp_c --> pi_c + thymd_c
damp_c + h2o_c --> pi_c + dad_dsh_2_c
h2o_c + amp_c --> pi_c + adn_c
dgmp_c + h2o_c --> pi_c + dgsn_c
gmp_c + h2o_c --> pi_c + gsn_c
dgtp_c + h2o_c --> ppi_c + dgmp_c + h_c
gtp_c + h2o_c --> ppi_c + gmp_c + h_c
h2o_c + dctp_c --> dcmp_c + ppi_c + h_c
ctp_c + h2o_c --> cmp_c + ppi_c + h_c
datp_c + h2o_c --> h_c + ppi_c + damp_c
atp_c + h2o_c --> amp_c + ppi_c + h_c
dttp_c + h2o_c --> dtmp_c + ppi_c + h_c
h2o_c + utp_c --> ump_c + ppi_c + h_c
dgtp_c + h2o_c --> pppi_c + dgsn_c
h2o_c + gtp_c --> pppi_c + gsn_c
no2_c + 3.0 nadh_c + 5.0 h_c --> 3.0 nad_c + 2.0 h2o_c + nh4_c
o2_e <=> o2_c
2obut_c + coa_c --> ppcoa_c + for_c
orn_c + cbp_c <=> citr_dsh_L_c + pi_c + h_c
h_e + ocdca_e --> ocdca_c + h_c
5.0 ipdp_c + frdp_c --> octdp_c + 5.0 ppi_c
ohpb_c + glu_dsh_L_c <=> akg_c + phthr_c
2ohph_c + amet_c --> h_c + 2omph_c + ahcys_c
amet_c + 2ombzl_c --> h_c + 2ommbl_c + ahcys_c
h_c + 3c4mop_c --> 4mop_c + co2_c
0.5 o2_c + 2ommbl_c --> 2omhmbl_c
h_c + orot5p_c --> co2_c + ump_c
0.5 o2_c + 2omph_c --> 2ombzl_c
h2o_c + op4en_c --> 4h2opntn_c
h_c + 3ophb_c --> 2oph_c + co2_c
0.5 o2_c + 2oph_c --> 2ohph_c
orn_c + h_c --> ptrc_c + co2_c
akg_c + orn_c --> glu_dsh_L_c + glu5sa_c
atp_c + orn_e + h2o_c --> orn_c + pi_c + h_c + adp_c
ppi_c + orot5p_c <=> prpp_c + orot_c
akg_c + h_c + thmpp_c --> co2_c + ssaltpp_c
nad_c + 1pyr5c_c + 2.0 h2o_c --> h_c + nadh_c + glu_dsh_L_c
2.0 h_c + nadph_c + 1pyr5c_c --> pro_dsh_L_c + nadp_c
coa_c + atp_c + pac_c --> phaccoa_c + ppi_c + amp_c
pant_dsh_R_c + atp_c + ala_dsh_B_c --> amp_c + h_c + ppi_c + pnto_dsh_R_c
h2o_c + 0.02 pa_EC_c --> pi_c + 0.02 12dgr_EC_c
ugmda_c + udcpp_c --> uagmda_c + ump_c
paps_c + trdrd_c --> so3_c + trdox_c + pap_c + 2.0 h_c
octeACP_c + 0.1 tdeACP_c + 0.72 palmACP_c + 0.04 myrsACP_c + glyc3p_c + 0.14 hdeACP_c --> 2.0 ACP_c + 0.02 pa_EC_c
pyr_c + coa_c + nad_c --> co2_c + nadh_c + accoa_c
o2_c + pdx5p_c <=> h2o2_c + pydx5p_c
phthr_c + nad_c + dxyl5p_c --> pi_c + pdx5p_c + h_c + co2_c + 2.0 h2o_c + nadh_c
pdx5p_c + h2o_c --> pi_c + pydxn_c
o2_c + h2o_c + peamn_c --> pacald_c + h2o2_c + nh4_c
h_c + 0.02 pe_EC_c + cmp_c <=> 0.02 12dgr_EC_c + cdpea_c
nad_c + 4per_c <=> h_c + ohpb_c + nadh_c
atp_c + f6p_c --> adp_c + fdp_c + h_c
atp_c + tag6p_dsh_D_c --> tagdp_dsh_D_c + adp_c + h_c
pyr_c + coa_c --> for_c + accoa_c
gam1p_c <=> gam6p_c
nad_c + 3pg_c --> 3php_c + nadh_c + h_c
g6p_c <=> f6p_c
atp_c + 3pg_c <=> 13dpg_c + adp_c
6pgl_c + h2o_c --> 6pgc_c + h_c
h2o_c + 2pglyc_c --> glyclt_c + pi_c
2pg_c <=> 3pg_c
g1p_c <=> g6p_c
h2o_c + 0.02 pgp_EC_c --> pi_c + 0.02 pg_EC_c
0.02 cdpdag_EC_c + glyc3p_c <=> cmp_c + 0.02 pgp_EC_c + h_c
akg_c + phe_dsh_L_c <=> glu_dsh_L_c + phpyr_c
h_e + phe_dsh_L_e <=> phe_dsh_L_c + h_c
atp_c + pi_e + h2o_c --> 2.0 pi_c + h_c + adp_c
h_e + pi_e <=> h_c + pi_c
0.02 pg_EC_c + h2o_c --> 0.07 hdcea_c + 0.5 ocdcea_c + h_c + 0.36 hdca_c + 0.02 agpg_EC_c + 0.02 ttdca_c + 0.05 ttdcea_c
0.02 pe_EC_c + h2o_c --> 0.02 agpe_EC_c + 0.07 hdcea_c + 0.5 ocdcea_c + h_c + 0.36 hdca_c + 0.02 ttdca_c + 0.05 ttdcea_c
h2o_c + 0.02 pc_EC_c --> h_c + 0.07 hdcea_c + 0.05 ttdcea_c + 0.02 agpc_EC_c + 0.36 hdca_c + 0.02 ttdca_c + 0.5 ocdcea_c
man1p_c <=> man6p_c
5aprbu_c + h2o_c --> pi_c + 4r5au_c
4ampm_c + atp_c --> adp_c + 2mahmp_c
atp_c + pnto_dsh_R_c --> 4ppan_c + adp_c + h_c
na1_e + pnto_dsh_R_e --> na1_c + pnto_dsh_R_c
pyr_c + q8_c + h2o_c --> ac_c + co2_c + q8h2_c
h2o_c + ppi_c --> h_c + 2.0 pi_c
adp_c + ppap_c <=> atp_c + ppa_c
2.0 5aop_c --> h_c + ppbng_c + 2.0 h2o_c
pep_c + co2_c + h2o_c --> oaa_c + pi_c + h_c
h_c + 4ppcys_c --> co2_c + pan4p_c
atp_c + oaa_c --> co2_c + adp_c + pep_c
ppcoa_c + succ_c --> succoa_c + ppa_c
r1p_c <=> r5p_c
2dr1p_c <=> 2dr5p_c
4ppan_c + ctp_c + cys_dsh_L_c --> h_c + cmp_c + 4ppcys_c + ppi_c
nad_c + pphn_c --> 34hpp_c + co2_c + nadh_c
h_c + pphn_c --> co2_c + phpyr_c + h2o_c
1.5 o2_c + pppg9_c --> 3.0 h2o_c + ppp9_c
pppn_c + h_c + o2_c + nadh_c --> cechddd_c + nad_c
h_e + pppn_e <=> pppn_c + h_c
pyr_c + atp_c + h2o_c --> amp_c + 2.0 h_c + pi_c + pep_c
uaagmda_c --> udcpdp_c + h_c + peptido_EC_c
atp_c + gly_c + pram_c <=> pi_c + h_c + gar_c + adp_c
fpram_c + atp_c --> 2.0 h_c + pi_c + air_c + adp_c
pran_c --> 2cpr5p_c
h2o_c + prbamp_c --> prfp_c
atp_c + asp_dsh_L_c + 5aizc_c <=> pi_c + h_c + 25aics_c + adp_c
h2o_c + prbatp_c --> ppi_c + prbamp_c + h_c
gln_dsh_L_c + atp_c + h2o_c + fgam_c --> fpram_c + h_c + pi_c + adp_c + glu_dsh_L_c
prfp_c --> prlp_c
fad_c + pro_dsh_L_c --> 1pyr5c_c + fadh2_c + h_c
atp_c + pro_dsh_L_e + h2o_c --> pi_c + h_c + adp_c + pro_dsh_L_c
h_e + pro_dsh_L_e <=> pro_dsh_L_c + h_c
pro_dsh_L_e + na1_e --> na1_c + pro_dsh_L_c
atp_c + r5p_c <=> amp_c + prpp_c + h_c
skm5p_c + pep_c <=> 3psme_c + pi_c
h_c + 0.02 ps_EC_c --> co2_c + 0.02 pe_EC_c
glu_dsh_L_c + 3php_c --> akg_c + pser_dsh_L_c
h2o_c + pser_dsh_L_c --> pi_c + ser_dsh_L_c
0.02 cdpdag_EC_c + ser_dsh_L_c <=> cmp_c + 0.02 ps_EC_c + h_c
pi_c + ppcoa_c --> coa_c + ppap_c
pi_c + accoa_c <=> coa_c + actp_c
pan4p_c + h_c + atp_c --> dpcoa_c + ppi_c
orn_c + ptrc_e <=> orn_e + ptrc_c
ptrc_c + akg_c --> glu_dsh_L_c + 4abutn_c
ptrc_e + atp_c + h2o_c --> ptrc_c + h_c + pi_c + adp_c
ptrc_e + h_e <=> ptrc_c + h_c
pi_c + adn_c <=> r1p_c + ade_c
dad_dsh_2_c + pi_c <=> 2dr1p_c + ade_c
gsn_c + pi_c <=> gua_c + r1p_c
dgsn_c + pi_c <=> 2dr1p_c + gua_c
ins_c + pi_c <=> hxan_c + r1p_c
pi_c + din_c <=> 2dr1p_c + hxan_c
xtsn_c + pi_c <=> r1p_c + xan_c
o2_c + pyam5p_c + h2o_c --> pydx5p_c + h2o2_c + nh4_c
pydam_c + atp_c --> pyam5p_c + h_c + adp_c
pydx_c + atp_c --> pydx5p_c + adp_c + h_c
pydxn_c + atp_c --> pdx5p_c + adp_c + h_c
h2o_c + pydx5p_c --> pi_c + pydx_c
h_c + pep_c + adp_c --> atp_c + pyr_c
uri_c + pi_c <=> r1p_c + ura_c
h_e + pyr_e <=> h_c + pyr_c
dhap_c + iasp_c --> quln_c + h_c + pi_c + 2.0 h2o_c
atp_c + ribflv_c --> fmn_c + adp_c + h_c
4r5au_c + db4p_c --> pi_c + dmlz_c + 2.0 h2o_c
2.0 dmlz_c --> 4r5au_c + ribflv_c
atp_c + rib_dsh_D_c --> h_c + adp_c + r5p_c
atp_c + rbl_dsh_L_c --> ru5p_dsh_L_c + adp_c + h_c
ru5p_dsh_L_c <=> xu5p_dsh_D_c
rhcys_c --> dhptd_c + hcys_dsh_L_c
atp_c + rib_dsh_D_e + h2o_c --> pi_c + adp_c + h_c + rib_dsh_D_c
rmn_c <=> rml_c
atp_c + rml_c --> adp_c + rml1p_c + h_c
h_e + rmn_e --> h_c + rmn_c
rml1p_c <=> lald_dsh_L_c + dhap_c
trdrd_c + adp_c --> trdox_c + h2o_c + dadp_c
trdrd_c + gdp_c --> trdox_c + dgdp_c + h2o_c
trdrd_c + cdp_c --> trdox_c + h2o_c + dcdp_c
trdrd_c + udp_c --> dudp_c + trdox_c + h2o_c
trdrd_c + atp_c --> trdox_c + h2o_c + datp_c
trdrd_c + gtp_c --> trdox_c + h2o_c + dgtp_c
trdrd_c + ctp_c --> trdox_c + h2o_c + dctp_c
trdrd_c + utp_c --> trdox_c + h2o_c + dutp_c
ru5p_dsh_D_c <=> xu5p_dsh_D_c
r5p_c <=> ru5p_dsh_D_c
5prdmbz_c + h2o_c --> rdmbzi_c + pi_c
s7p_c --> gmhep7p_c
2.0 h_c + sucarg_c + 2.0 h2o_c --> sucorn_c + co2_c + 2.0 nh4_c
gtp_c + atp_c + so4_c + h2o_c --> aps_c + pi_c + gdp_c + ppi_c
nad_c + sbt6p_c <=> nadh_c + f6p_c + h_c
sbt_dsh_D_e + pep_c --> sbt6p_c + pyr_c
h2o_c + sl26da_c --> 26dap_dsh_LL_c + succ_c
akg_c + sl26da_c <=> glu_dsh_L_c + sl2a6o_c
atp_c + seln_c + h2o_c --> amp_c + pi_c + selnp_c
atp_c + h_c + ser_dsh_L_c <=> seramp_c + ppi_c
ser_dsh_L_c + accoa_c <=> acser_c + coa_c
ser_dsh_D_c --> nh4_c + pyr_c
ser_dsh_L_c --> nh4_c + pyr_c
h_e + ser_dsh_L_e <=> h_c + ser_dsh_L_c
ser_dsh_L_e + na1_e --> na1_c + ser_dsh_L_c
h2o_c + sucglu_c --> glu_dsh_L_c + succ_c
nad_c + h2o_c + sucgsa_c --> 2.0 h_c + sucglu_c + nadh_c
ssaltpp_c + ichor_c --> 2shchc_c + thmpp_c + pyr_c
dscl_c + nad_c --> nadh_c + scl_c + h_c
fe2_c + scl_c --> 3.0 h_c + sheme_c
nadph_c + h_c + 3dhsk_c <=> nadp_c + skm_c
atp_c + skm_c --> skm5p_c + adp_c + h_c
suchms_c + cys_dsh_L_c --> cyst_dsh_L_c + succ_c + h_c
sucorn_c + akg_c --> sucgsa_c + glu_dsh_L_c
spmd_c + accoa_c --> N1aspmd_c + coa_c + h_c
spmd_c + accoa_c --> coa_c + n8aspmd_c + h_c
atp_c + h2o_c + spmd_e --> spmd_c + pi_c + h_c + adp_c
ptrc_c + ametam_c --> 5mta_c + spmd_c + h_c
2.0 o2s_c + 2.0 h_c --> o2_c + h2o2_c
sucsal_c + nad_c + h2o_c --> 2.0 h_c + nadh_c + succ_c
nadp_c + sucsal_c + h2o_c --> 2.0 h_c + nadph_c + succ_c
coa_c + atp_c + sucbz_c --> sbzcoa_c + ppi_c + amp_c
2shchc_c --> h2o_c + sucbz_c
succ_e + atp_c + h2o_c --> pi_c + adp_c + h_c + succ_c
2.0 h_e + succ_e --> 2.0 h_c + succ_c
3.0 h_e + succ_e --> 3.0 h_c + succ_c
h_c + succ_c --> h_e + succ_e
fad_c + succ_c --> fadh2_c + fum_c
q8_c + fadh2_c <=> fad_c + q8h2_c
fum_e + succ_c <=> fum_c + succ_e
coa_c + succ_c + atp_c <=> pi_c + succoa_c + adp_c
pep_c + sucr_e --> pyr_c + suc6p_c
3.0 nadp_c + h2s_c + 3.0 h2o_c <=> so3_c + 3.0 nadph_c + 5.0 h_c
so4_e + atp_c + h2o_c --> h_c + pi_c + so4_c + adp_c
nad_c + altrn_c <=> h_c + nadh_c + tagur_c
s7p_c + g3p_c <=> f6p_c + e4p_c
tartr_dsh_L_c --> h2o_c + oaa_c
tartr_dsh_L_e + succ_c <=> succ_e + tartr_dsh_L_c
taur_c + o2_c + akg_c --> h_c + so3_c + co2_c + succ_c + aacald_c
atp_c + taur_e + h2o_c --> taur_c + pi_c + h_c + adp_c
dtdp4addg_c + accoa_c --> h_c + coa_c + dtdp4aaddg_c
glu_dsh_L_c + dtdp4d6dg_c --> akg_c + dtdp4addg_c
dtdp4d6dg_c --> dtdp4d6dm_c
h_c + nadph_c + dtdp4d6dm_c --> dtdprmn_c + nadp_c
dtdpglu_c --> h2o_c + dtdp4d6dg_c
atp_c + lipidAds_c --> lipidA_c + adp_c + h_c
tagdp_dsh_D_c <=> dhap_c + g3p_c
nadp_c + nadh_c + 2.0 h_e --> nad_c + nadph_c + 2.0 h_c
succoa_c + h2o_c + thdp_c --> coa_c + sl2a6o_c
h_e + thymd_e --> h_c + thymd_c
h_e + thymd_e <=> h_c + thymd_c
thm_e + atp_c + h2o_c --> pi_c + h_c + thm_c + adp_c
thr_dsh_L_c <=> acald_c + gly_c
nad_c + thr_dsh_L_c --> nadh_c + 2aobut_c + h_c
thr_dsh_L_c --> 2obut_c + nh4_c
h2o_c + phom_c --> pi_c + thr_dsh_L_c
thr_dsh_L_e + atp_c + h2o_c --> thr_dsh_L_c + h_c + pi_c + adp_c
h_e + thr_dsh_L_e <=> h_c + thr_dsh_L_c
na1_e + thr_dsh_L_e --> na1_c + thr_dsh_L_c
tyr_dsh_L_c + dxyl5p_c + cys_dsh_L_c + atp_c --> ala_dsh_L_c + 4mpetz_c + h_c + co2_c + 4hba_c + h2o_c + ppi_c + amp_c
xu5p_dsh_D_c + r5p_c <=> s7p_c + g3p_c
xu5p_dsh_D_c + e4p_c <=> f6p_c + g3p_c
mql8_c + h_c + tmao_c --> mqn8_c + tma_c + h2o_c
tmao_e + h_e + mql8_c --> h2o_e + tma_e + mqn8_c
2dmmql8_c + h_c + tmao_c --> 2dmmq8_c + tma_c + h2o_c
tmao_e + 2dmmql8_c + h_e --> h2o_e + tma_e + 2dmmq8_c
atp_c + thymd_c --> adp_c + dtmp_c + h_c
pi_c + thymd_c <=> 2dr1p_c + thym_c
mlthf_c + dump_c --> dhf_c + dtmp_c
atp_c + thm_c <=> thmmp_c + adp_c + h_c
atp_c + thmmp_c <=> thmpp_c + adp_c
2mahmp_c + 4mpetz_c + h_c --> ppi_c + thmmp_c
dhap_c <=> g3p_c
nadph_c + trdox_c + h_c --> nadp_c + trdrd_c
h2o_c + tre6p_c --> g6p_c + glc_dsh_D_c
h2o_c + tre6p_c --> pi_c + tre_c
udpg_c + g6p_c --> udp_c + tre6p_c + h_c
h2o_c + tre_c --> 2.0 glc_dsh_D_c
h2o_e + tre_e --> 2.0 glc_dsh_D_e
tre_e + pep_c --> tre6p_c + pyr_c
h2o_c + trp_dsh_L_c <=> pyr_c + indole_c + nh4_c
3ig3p_c + ser_dsh_L_c --> trp_dsh_L_c + g3p_c + h2o_c
indole_c + ser_dsh_L_c --> trp_dsh_L_c + h2o_c
3ig3p_c --> g3p_c + indole_c
h_e + trp_dsh_L_e <=> h_c + trp_dsh_L_c
h_c + nadh_c + 2h3oppan_c --> glyc_dsh_R_c + nad_c
tsul_e + atp_c + h2o_c --> h_c + pi_c + tsul_c + adp_c
h_e + ttdca_e --> ttdca_c + h_c
akg_c + tyr_dsh_L_c <=> 34hpp_c + glu_dsh_L_c
h_e + tyr_dsh_L_e <=> tyr_dsh_L_c + h_c
3hmrsACP_c + u3hga_c --> u23ga_c + h_c + ACP_c
26dap_dsh_M_c + atp_c + uamag_c --> ugmd_c + pi_c + h_c + adp_c
2.0 nad_c + uacmam_c + h2o_c --> 3.0 h_c + 2.0 nadh_c + uacmamu_c
uacgam_c --> uacmam_c
3hmrsACP_c + uacgam_c <=> u3aga_c + ACP_c
pep_c + uacgam_c --> pi_c + uaccg_c
h_c + utp_c + acgam1p_c --> ppi_c + uacgam_c
uacgam_c + uagmda_c --> udp_c + uaagmda_c + h_c
glu_dsh_D_c + uama_c + atp_c --> h_c + pi_c + uamag_c + adp_c
uamr_c + ala_dsh_L_c + atp_c --> h_c + pi_c + adp_c + uama_c
nadph_c + uaccg_c + h_c --> uamr_c + nadp_c
h2o_c + udcpdp_c --> pi_c + udcpp_c + h_c
frdp_c + 8.0 ipdp_c --> udcpdp_c + 8.0 ppi_c
udpg_c <=> udpgal_c
udpgal_c --> udpgalfur_c
2.0 nad_c + udpg_c + h2o_c --> udpglcur_c + 3.0 h_c + 2.0 nadh_c
udpg_c + gal1p_c <=> g1p_c + udpgal_c
urdglyc_c + 2.0 h_c + h2o_c --> glx_c + co2_c + 2.0 nh4_c
atp_c + ugmd_c + alaala_c --> h_c + pi_c + ugmda_c + adp_c
u3aga_c + h2o_c --> u3hga_c + ac_c
atp_c + ump_c <=> adp_c + udp_c
2kmb_c + glu_dsh_L_c --> akg_c + met_dsh_L_c
uppg3_c + 2.0 amet_c --> dscl_c + 2.0 ahcys_c + h_c
hmbil_c --> h2o_c + uppg3_c
4.0 h_c + uppg3_c --> 4.0 co2_c + cpppg3_c
prpp_c + ura_c --> ppi_c + ump_c
h_e + ura_e --> ura_c + h_c
h_e + ura_e <=> ura_c + h_c
urea_e <=> urea_c
atp_c + dump_c <=> dudp_c + adp_c
uri_c + gtp_c --> gdp_c + ump_c + h_c
h_e + uri_e --> uri_c + h_c
h_e + uri_e <=> uri_c + h_c
h2o_c + u23ga_c --> lipidX_c + ump_c + 2.0 h_c
akg_c + val_dsh_L_c <=> glu_dsh_L_c + 3mob_c
atp_c + val_dsh_L_e + h2o_c --> pi_c + h_c + adp_c + val_dsh_L_c
h_e + val_dsh_L_e <=> h_c + val_dsh_L_c
3mob_c + ala_dsh_L_c --> pyr_c + val_dsh_L_c
xu5p_dsh_L_c --> ru5p_dsh_L_c
xan_e <=> xan_c
h_e + xan_e --> xan_c + h_c
prpp_c + xan_c --> ppi_c + xmp_c
xtsn_e + h_e <=> xtsn_c + h_c
xyl_dsh_D_c <=> xylu_dsh_D_c
fru_c --> glc_dsh_D_c
xylu_dsh_D_c + atp_c --> xu5p_dsh_D_c + h_c + adp_c
atp_c + xyl_dsh_D_e + h2o_c --> xyl_dsh_D_c + pi_c + h_c + adp_c
h_e + xyl_dsh_D_e --> h_c + xyl_dsh_D_c

In [4]:

    

from cameo.flux_analysis import simulation


    

In [5]:

    

help(simulation)


    

    




Help on module cameo.flux_analysis.simulation in cameo.flux_analysis:

NAME
    cameo.flux_analysis.simulation

FILE
    /Users/joao/Documents/repos/cameo/cameo/flux_analysis/simulation.py

DESCRIPTION
    Methods for simulating flux distributions.
    Currently implements:
    * fba - Flux Balance Analysis
    * pfba - Parsimonious Flux Balance Analysis
    * lmoma - (Linear) Minimization of Metabolic Adjustment
    * room - Regulatory On/Off Minimization

FUNCTIONS
    fba(model, objective=None, *args, **kwargs)
        Flux Balance Analysis.
        
        Parameters
        ----------
        model: SolverBasedModel
        objective: a valid objective - see SolverBaseModel.objective (optional)
        
        Returns
        -------
        FluxDistributionResult
            Contains the result of the linear solver.
    
    lmoma(model, reference=None, cache={}, volatile=True, *args, **kwargs)
        Linear Minimization Of Metabolic Adjustment.
        
        Parameters
        ----------
        model: SolverBasedModel
        reference: dict
        objective: str or reaction or optlang.Objective
            An objective to be minimized/maximized for
        volatile: boolean
        cache: dict
        
        Returns
        -------
        FluxDistributionResult
            Contains the result of the linear solver.
    
    moma(model, reference=None, *args, **kwargs)
    
    pfba(model, objective=None, *args, **kwargs)
        Parsimonious Flux Balance Analysis.
        
        Parameters
        ----------
        model: SolverBasedModel
        objective: str or reaction or optlang.Objective
            An objective to be minimized/maximized for
        
        Returns
        -------
        FluxDistributionResult
            Contains the result of the linear solver.
    
    room(model, reference=None, cache={}, volatile=True, delta=0.03, epsilon=0.001, *args, **kwargs)
        Regulatory On/Off Minimization [1].
        
        Parameters
        ----------
        model: SolverBasedModel
        reference: dict
        objective: str or reaction or optlang.Objective
            An objective to be minimized/maximized for
        volatile: boolean
        cache: dict
        
        Returns
        -------
        FluxDistributionResult
            Contains the result of the linear solver.
        
        References
        ----------
        [1] Tomer Shlomi, Omer Berkman and Eytan Ruppin, "Regulatory on/off minimization of metabolic
        flux changes after genetic perturbations", PNAS 2005 102 (21) 7695-7700; doi:10.1073/pnas.0406346102

DATA
    __all__ = ['fba', 'pfba', 'moma', 'lmoma', 'room']

In [6]:

    

%time
fba_result = simulation.fba(model)


    

    




CPU times: user 3 µs, sys: 1e+03 ns, total: 4 µs
Wall time: 6.91 µs

In [7]:

    

%time
pfba_result = simulation.pfba(model)


    

    




CPU times: user 3 µs, sys: 1 µs, total: 4 µs
Wall time: 6.91 µs

In [9]:

    

model.reactions.PGI


    

    
Out[9]:





        

            

                
Id
PGI
            
            

                
Stoichiometry
g6p_c <=> f6p_c
            
            

                
Lower bound
-999999.000000
            
            

                
Upper bound
999999.000000
            
        
        

In [10]:

    

model.reactions.PGI.knock_out()
model.reactions.PGI


    

    
Out[10]:





        

            

                
Id
PGI
            
            

                
Stoichiometry
g6p_c --> f6p_c
            
            

                
Lower bound
0.000000
            
            

                
Upper bound
0.000000
            
        
        

In [11]:

    

%time
fba_knockout_result = simulation.fba(model)
fba_knockout_result[model.objective]


    

    




CPU times: user 2 µs, sys: 0 ns, total: 2 µs
Wall time: 5.01 µs






    
Out[11]:





0.905983

In [12]:

    

pfba_knockout_result = simulation.pfba(model)
pfba_knockout_result[model.objective]


    

    
Out[12]:





0.905983

In [26]:

    

lmoma_result["2 * EX_glc_lp_e_rp_"]


    

    
Out[26]:





-18.7358

In [14]:

    

%time
lmoma_result = simulation.lmoma(model, reference=pfba_result.fluxes)
lmoma_result[model.objective]


    

    




CPU times: user 2 µs, sys: 1 µs, total: 3 µs
Wall time: 5.01 µs






    
Out[14]:





0.791393

In [19]:

    

%time
room_result = simulation.room(model, reference=pfba_result.fluxes)
room_result[model.objective]


    

    




CPU times: user 2 µs, sys: 1 µs, total: 3 µs
Wall time: 5.01 µs






    
Out[19]:





0.887440

In [27]:

    

room_result


    

    
Out[27]:





<cameo.core.result.FluxDistributionResult at 0x10aa75b50>

In [ ]: